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EricTopol's profile
Eric Topol
Eric Topol
Eric Topol
Verified account
@EricTopol

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Eric TopolVerified account

@EricTopol

physician-scientist, author, editor. My new book #DeepMedicine will be available on March 12. Pre-order: http://bit.ly/DeepMedicine 

La Jolla, CA
scripps.edu/translational
Joined November 2009

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    Eric Topol‏Verified account @EricTopol Jan 26

    —How good is #AI for prediction in medicine? —We don't know. All 15 papers I've summarized are in silico, retrospective, many w/ statistical methodologic issues, and we've yet to see a prospective validation study in a real world clinical environment https://www.nature.com/articles/s41591-018-0300-7 … #OApic.twitter.com/4HbrJu4zoK

    9:51 AM - 26 Jan 2019
    • 446 Retweets
    • 750 Likes
    • Annalaura M. PhD Xin MENG Hagai Rossman Sam Riley Пионерка Jens Rabis Cecilia Lindskog SurfeurGeek Rahat Warraich PhD
    Nature Medicine
    31 replies 446 retweets 750 likes
      1. New conversation
      2. Frank A. Krueger‏ @praeclarum Jan 26
        Replying to @EricTopol @anooj @NatureMedicine

        —How good are doctors for prediction in medicine? —We don't know.

        2 replies 8 retweets 41 likes
      3. Eric Topol‏Verified account @EricTopol Jan 26
        Replying to @praeclarum @anooj @NatureMedicine

        We do know, They/we are not good at that, substantiated by many studies. And that has set the stage for help from machines, #AI.

        1 reply 4 retweets 30 likes
      4. 1 more reply
      1. New conversation
      2. Bernadette Keefe MD‏ @nxtstop1 Jan 27
        Replying to @EricTopol @NatureMedicine

        Rec.: "High-performance medicine: the convergence of human and artificial intelligence"––@EricTopol 's January 2019 in @NatureMedicine A breathtaking overview of the wide ranging research into applications of #AI in #medicine –– and how/why it has fallen short of clinical use.pic.twitter.com/I1QlVyqc2x

        1 reply 7 retweets 8 likes
      3. 1 more reply
      1. New conversation
      2. Andrew Matzkin‏ @MatzkinHealth Jan 27
        Replying to @EricTopol @NatureMedicine

        Isn’t this kind of like asking, how good is Excel or R? ML/DL is really just (sophisticated) math. If the data is good, the algorithms will be good. How we use them is the more interesting question, IMO.

        3 replies 1 retweet 4 likes
      3. Atul Butte‏Verified account @atulbutte Jan 27
        Replying to @MatzkinHealth @EricTopol @NatureMedicine

        Yes, but no one ever suggested replacing doctors with Excel or R. Yet that's what is being suggested by some with #AI…

        2 replies 0 retweets 5 likes
      4. 1 more reply
      1. New conversation
      2. Robert Gergely, MD‏ @rgergelymd Jan 26
        Replying to @EricTopol @NatureMedicine

        #AI will become valuable for prediction in medicine, ONLY when every citizen will have a LONGITUDINAL medical record. From conception to death. Think about the opportunities.....https://www.linkedin.com/pulse/health-care-re-imagined-robert-gergely-md/ …

        2 replies 1 retweet 5 likes
      3. Aurelia Cotta‏ @AureliaCotta Jan 26
        Replying to @rgergelymd @EricTopol @NatureMedicine

        That would also require the person to live with no changes, no science, no new developments. No life changes, no economic changes, random events---and that hasn't been human experience for hundreds of years.

        1 reply 1 retweet 2 likes
      4. 1 more reply
      1. Salim S. Hayek‏ @salimhayek Jan 26
        Replying to @EricTopol @NatureMedicine

        AI will only ever be as good as the data that we feed it. Medical data is neither granular enough or accurate for an AI that would surpass a physician’s overall clinical assessment. But in data such as imaging, AI already surpasses us...

        0 replies 2 retweets 4 likes
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      1. New conversation
      2. Degui Zhi‏ @zhizhid Jan 26
        Replying to @EricTopol @NatureMedicine

        Shamelessly plugging in our result: Heart Failure, n=1,150,000, AUC=0.82, Rasmy et al https://www.sciencedirect.com/science/article/pii/S1532046418301175?via%3Dihub …

        1 reply 1 retweet 1 like
      3. Eero Teppo‏ @eero_teppo Jan 26
        Replying to @zhizhid @EricTopol @NatureMedicine

        Wow, only 3% more accurate than logistic regression? Clearly the data didn't contain sequential, non-linear, nor hierarchical patterns almost at all.

        1 reply 0 retweets 2 likes
      4. Degui Zhi‏ @zhizhid Jan 26
        Replying to @eero_teppo @EricTopol @NatureMedicine

        Admittedly, data is very noisy. Maybe a bit lack of sequential. But non-linear embedding helps: Logistic regression without embedding is 6% lower (76%), while LR on top embedding is 79%.

        0 replies 0 retweets 2 likes
      5. End of conversation
      1. New conversation
      2. Sherry Reynolds  🌟‏ @Cascadia Jan 27
        Replying to @EricTopol @NatureMedicine

        #AI could transform stock trading - one of the purest data sectors And there are many use cases in medicine, but most data geeks don’t realize just how much of healthcare is an art, how hard it is to get clean data or how most isn’t clinical and how complex the human body is

        1 reply 1 retweet 3 likes
      3. Mike Moore, DO‏ @MikeMooreDO Jan 27
        Replying to @Cascadia @EricTopol @NatureMedicine

        Regarding #AI in Medicine: I think that getting people to do the right thing (healthy & safe choices) is a much more pressing need than helping physicians find the right thing to do. #meded

        0 replies 0 retweets 1 like
      4. End of conversation
      1. Mo Elshazly MD‏ @mbelshazly Jan 26
        Replying to @EricTopol @NatureMedicine

        I think we can significantly benefit from researchers sharing the #AI algorithms they used, maybe after patenting, so that other investigators can validate/reproduce the results in prospective studies.

        0 replies 2 retweets 2 likes
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      1. Kamal Maheshwari‏ @KamalMaheshwar7 Jan 26
        Replying to @EricTopol @NatureMedicine

        Agreed 1. Data is still limited; 2. External validation in minimum two or more data sets is needed; 3. RCT for efficacy/effectiveness is needed e.g. we are (NCT03610165) evaluating an prediction algorithm. 4. PPV and NPV should always be reported.

        0 replies 2 retweets 2 likes
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