http://science.sciencemag.org/content/347/6217/81 … men who smoke are more than 3 times as likely as nonsmokers to show loss of the Y chromosome in their blood cells.
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706411/ … age-related loss of chromosome Y (LOY) in normal hematopoietic cells is a well-known phenomenon
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https://pdfs.semanticscholar.org/c475/1f3185fa4e496e21f289c43501026c550cee.pdf … the prognostic value of the loss of Y- is difficult to assess... it commonly occurs in normal cells of elderly men
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http://www.genetics.org/content/179/3/1513 … Y chromosomes are unusual relative to the rest of the genome, since they carry few functional genes
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