Ellen Foxman

@EllenFoxman

Asst. professor , . We study innate defense against viruses with a view to better prevention, diagnosis, treatment. Opinions are my own.

Yale University
Liittynyt maaliskuu 2012

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  1. Kiinnitetty twiitti
    21. kesäk.

    My first tweetorial! On our new and viral interference study . It started with puzzling observations that pointed to the importance of kinetics. We saw a robust interferon response in the upper airway in all COVID patients studied, mild and severe:

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  2. uudelleentwiittasi
    21. jouluk.

    Dr. Collins cites "misinformation and disinformation that somehow dominated all of the ways in which people were getting their answers. And a lot of those answers were, in fact, false. And we have lost so much as a result"

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  3. uudelleentwiittasi
    18. jouluk.

    “I did not sign up to see people die needlessly” Watch this courageous testimony from Dr. Bosslet, pulmonary, critical care physician. All our professional societies should amplify! Thank you

    , , ja 7 muuta
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  4. uudelleentwiittasi
    3. jouluk.

    🦠 There’s a lot we don’t yet understand about Omicron, including its impact on immunity and what it means for vaccines. New data will be emerging over the next few wks, which could be misinterpreted w/o context. What we might expect & how to interpret the emerging data? 🧵(1/n)

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  5. 18. jouluk.

    Omicron appears to be spreading fast in CT

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  6. uudelleentwiittasi
    17. jouluk.

    Doubling of hospital admissions in the past five days! Hospitalized patients are overwhelmingly unvaccinated; these serious illnesses are preventable with safe & effective . And booster dose can overcome lower vaccine affinity w/ .

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  7. uudelleentwiittasi
    11. jouluk.

    1/Our paper exploring how mucosal gene expression in children prior to respiratory viral infection affects subsequent viral loads, using live attenuated influenza vaccine as a challenge . Wonderful collaboration with

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  8. uudelleentwiittasi
    16. jouluk.
    Vastauksena käyttäjälle

    Very relevant to your comment on implications for SARSCoV2 is this great paper from impact of preceding rhinovirus on ISGs and SARSCoV2 in airway epithelial organoids

    Kumoa
  9. 16. jouluk.

    Thank you for highlighting our study on how dynamic innate immunity impacts COVID infection, including the influence of recent rhinovirus exposure.

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  10. 15. jouluk.

    and other unexplained epidemiology suggesting viral interference - as seen in the 2009 H1N1 "swine flu" pandemic in Europe

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  11. 15. jouluk.

    And that such interactions may also impact timing of epidemic and pandemics as seen in the typical staggering of rhinovirus and influenza epidemics

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  12. 15. jouluk.

    This intriguing data supports the idea that subclinical viral infections influence mucosal innate immunity and may explain some of the great variability in susceptibility to respiratory viruses - perhaps including COVID-19

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  13. 15. jouluk.

    Beautiful study just out showing that rhinovirus and other asymptomatic viral infections induced mucosal antiviral responses and interfered with replication of live attenuated influenza vaccine in seronegative children

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  14. 15. jouluk.

    Omicron on the rise in CT. Time for booster ASAP.

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  15. 14. jouluk.

    If you haven’t done it already, time for a flu shot!

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  16. uudelleentwiittasi
    13. jouluk.

    At , we continue to screen positive specimens using SGTF. Confirmation by sequencing usually lags by a few days, but we expect the majority of these SGTFs to be Omicron. If so, definitely seeing a rapid rise similar to reports from South Africa, UK, Denmark, etc.

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  17. uudelleentwiittasi
    12. jouluk.

    Not the first, but a quite comprehensive analyses of Omicron neutralization resistance with , Bottom line is fairly consistent with other mini-studies out this week, some quantitative discrepancies between groups

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  18. uudelleentwiittasi
    12. jouluk.

    KEY POINT: Increasing immunity with an mRNA booster shot on top of prior infection or prior 2x mRNA vaccination confers 30x to 200x higher neutralization titers vs Omicron or PMS20

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  19. uudelleentwiittasi
    12. jouluk.
    Kumoa
  20. 11. jouluk.

    Cast your vote - Science Twitter poll for discovery of the year!

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  21. 11. jouluk.

    So important - may just appear to be "milder" because people exposed were mostly low-risk or previously exposed/vaccinated. Could easily be just as serious as prior strains, especially for unvaccinated.

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