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Ed Huttlin proslijedio/la je Tweet
About a week and a half ago we published our paper and data for the quantitative proteomes of the Cancer Cell Line Encyclopedia. In response to questions we had about the data we’ve written a guide that’s up now on BioRxiv https://www.biorxiv.org/content/10.1101/2020.02.03.932384v1 … 1/5https://twitter.com/dnusinow/status/1220393141011795968 …
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Ed Huttlin proslijedio/la je Tweet
Really excited to publish this Perspective today, open access! A huge project since 2001. https://www.nature.com/articles/s41592-019-0686-2 …
@TylerReddy@ralfgommersHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Ed Huttlin proslijedio/la je Tweet
An exciting update on our Cancer Cell Line Encyclopedia: Quantified proteome profiles for 375 cell lines in
@CellCellPress.@NovartisSciencehttps://www.cell.com/cell/fulltext/S0092-8674(19)31385-6#%20 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Are you interested in mass spectrometry? Check out this year's
#MassSpecSummerSchool in Madison, Wisconsin! I'm excited to be speaking this year and highly encourage you to apply. You will learn a ton - and Madison is a great place to visit, especially in the summer!https://twitter.com/Coon_Labs/status/1222561489615278080 …
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Congratulations to Brian,
@dschweppe1,@qingyuhms, and the rest of the authors from@GygiLab and@IQProteomics! Parallel notched gas-phase enrichment for improved proteome identification and quantitation with fast spectral acquisition rateshttps://pubs.acs.org/doi/10.1021/acs.jproteome.9b00715#.XjCr3k_eGQh.twitter …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Ed Huttlin proslijedio/la je Tweet
This is the HMS write up of the incredible
@nature paper published this week from@GygiLab member Marian Kalocsay and Steven Marx at Columbia. Proximity labeling in a living heart!https://twitter.com/harvardmed/status/1221130883668828160 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Ed Huttlin proslijedio/la je Tweet
Study reveals a missing link in the mechanisms that drive the fight-or-flight responsehttp://hvrd.me/Dm8d30qbLgo
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Ed Huttlin proslijedio/la je Tweet
Quantitative proteomic profiling of 375 cell lines from from Cancer Cell Line Encyclopedia http://bit.ly/2tMtaeX
#NBThighlightHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Ed Huttlin proslijedio/la je Tweet
Very impressive


big congratulations to all the authors. Must read paper for all #CancerResearch#cancer#therapy overwhelmed by seeing that much data with humongous figuresHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Ed Huttlin proslijedio/la je Tweet
Phosphorylation is a post-translational modification with a vital role in cellular signaling. This study develops a workflow with FAIMS coupled to Orbitrap MS for a multiplexed analysis of tandem mass tag-labeled peptideshttp://acspubs.co/Xx5u30qb97a
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Ed Huttlin proslijedio/la je TweetHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi
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Proteome profiles for 375 cancer cell lines: congratulations to
@dnusinow of the@GygiLab and all other co-authors on this massive achievement! Check out the paper to see what they've learned! Quantitative Proteomics of the Cancer Cell Line Encyclopediahttps://www.cell.com/cell/fulltext/S0092-8674(19)31385-6#.XinaR57f6bQ.twitter …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Ed Huttlin proslijedio/la je Tweet
I probably should have put it in the first tweet, but the manuscript is available at https://www.cell.com/cell/fulltext/S0092-8674(19)31385-6 … !
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Ed Huttlin proslijedio/la je Tweet
I’m thrilled to announce the publication of the quantitive proteomic profiling of the Cancer Cell Line Encyclopedia. The
@GygiLab in collaboration with colleagues at Novartis and the Broad we measured the proteomes of 375 cell lines from various tumor lineages (1/13)pic.twitter.com/WXgsODMzFs
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Ed Huttlin proslijedio/la je Tweet
My laboratory is recruiting a graduate student
@UPEI,@UPEI_Biology,@research_upei to study the activity and function of cellular metabolites using proteomics and metabolomics. If this interests you, please get in touch by DM (laboratory website in the works).Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
APEX proximity labeling - in beating mouse hearts! - reveals new molecular details of how the heart responds to stressful situations. Congratulations to all authors, including Marian Kalocsay from the
@GygiLab!http://disq.us/t/3lidw65Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
For more information, see our bioRxiv preprint! Also follow us
@HMSBioPlex and check out http://bioplex.hms.harvard.edu ! This project is a collaboration between@GygiLab and the Harper lab (@jwadeharper1) in the@HarvardCellBio department. 8/8Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Other results: 1) we ID ~1400 protein communities, many cell-specific. 2) we look at interactions among kinases and other families. 3) we link new proteins with CORUM complexes. 4) we combine BioPlex and
@CancerDepMap to ID physically & functionally associated subnetworks. 7/8pic.twitter.com/pa5Zxs5ApN
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Even when a protein’s interacting partners differ between cell lines, they tend to be functionally consistent. For example, as expected, we find that TRIM28 interacts with ~150 KRAB-domain-containing zinc-finger proteins. But we see different KRAB-Znf’s in each cell line. 6/8pic.twitter.com/3DXhrlREGf
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Where do differences come from? Some reflect biology. The DREAM complex is disrupted in 293T due to large T antigen. And interactions among evolutionarily ‘old’ or essential proteins are consistent while interactions among ‘young’ or non-essential proteins are cell-specific. 5/8pic.twitter.com/48PDsvr08s
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