For real though I am so salty that grifters have chosen to base their grift around one of the most complex and branched metabolic pathways in mammals that also manages to involve over 150 discrete compounds
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And why does DHFR reduce folic acid and not just dihydrofolate?
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It catalyzes both reactions. It makes DHF from folic acid and makes THF from DHF
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Something something DNA synthesis something something antimebolites can get very messy something something B12 and vegans
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That's the gist yes. But also there are some cool parts to it. Like overconsumption of folate is basically benign but it can correct B12 deficiency-associated anemia but not neurological damage so it can mask B12 deficiency which is the principal danger.
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Lots of work in the one-carbon department. I think folate was recruited to help out... or at least for a consulting gig.
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