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ENirenberg's profile
Edward Nirenberg
Edward Nirenberg
Edward Nirenberg
@ENirenberg

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Edward Nirenberg

@ENirenberg

Views my own. Anti-disease. Big Nerd Energy. Compliments not accepted; constructive criticism from qualified individuals strongly preferred. he/him

United States
deplatformdisease.com
Joined September 2016

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    Edward Nirenberg‏ @ENirenberg 1 Dec 2020

    Hi guys. I just wanted to put a quick thread out here about a concern I'm seeing a lot today re vaccines for COVID-19 and their potential for long-term effects. I have a more detailed post on my blog here but I can give you the cliff-notes.https://www.deplatformdisease.com/blog/long-term-effects-of-covid-19-vaccines-should-you-be-worried …

    3:19 PM - 1 Dec 2020
    • 101 Retweets
    • 225 Likes
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    14 replies 101 retweets 225 likes
      1. New conversation
      2. Edward Nirenberg‏ @ENirenberg 1 Dec 2020

        I get why people have this concern, so let's take a look. For almost every vaccine we have, there is no such thing as a long-term adverse effect that appears only years after the initial vaccination. If you examine the exception it's easy to understand why.

        2 replies 1 retweet 36 likes
        Show this thread
      3. Edward Nirenberg‏ @ENirenberg 1 Dec 2020

        Varicella vaccines contain a live-attenuated varicella zoster virus. It's the same virus that causes chickenpox, shingles, and all the other fun stuff that varicella does, but the strain (called Oka) is adapted to be unable to grow effectively inside human cells.

        1 reply 0 retweets 25 likes
        Show this thread
      4. Edward Nirenberg‏ @ENirenberg 1 Dec 2020

        The outcome of vaccination is that the immune system gets all the information it needs to be able to defend against infection, and even though you have the varicella virus in you, it doesn't cause disease. Because varicella can't establish an infection, you also avoid shingles.

        2 replies 0 retweets 27 likes
        Show this thread
      5. Edward Nirenberg‏ @ENirenberg 1 Dec 2020

        Still, some people who get this vaccine might develop shingles from the Oka strain years down the line. This is rare. It's also much more likely to happen from the Zostavax vaccine, which elderly people get to prevent shingles, rather than childhood varicella vaccines.

        1 reply 0 retweets 23 likes
        Show this thread
      6. Edward Nirenberg‏ @ENirenberg 1 Dec 2020

        Varicella causes shingles when your immune system weakens (which can happen from any number of things) and reactivates from latency inside your nerves.

        1 reply 0 retweets 24 likes
        Show this thread
      7. Edward Nirenberg‏ @ENirenberg 1 Dec 2020

        Despite the deservedly fearsome reputation of shingles, the cases from the vaccine tend to be much milder, likely because it's still a weakened virus. And you are still MUCH more likely to get shingles from a past chickenpox infection (about 30%) so it's very much worth getting.

        1 reply 0 retweets 28 likes
        Show this thread
      8. Edward Nirenberg‏ @ENirenberg 1 Dec 2020

        The ability of a vaccine to cause these effects years down the line depends on 2 things: 1) The use of a live-attenuated vaccine 2) The ability of varicella viruses, being herpesviruses, to cause persistent infection Neither of these things alone are sufficient.

        1 reply 1 retweet 29 likes
        Show this thread
      9. Edward Nirenberg‏ @ENirenberg 1 Dec 2020

        The vaccines for COVID-19/SARS-CoV-2 currently in phase 3 do not meet either of these conditions. mRNA vaccines have a lifetime of maybe a few hours (at most) inside your cells, after which enzymes inside your own cells destroy them.

        1 reply 2 retweets 35 likes
        Show this thread
      10. Edward Nirenberg‏ @ENirenberg 1 Dec 2020

        The Oxford/AZ vaccine is a vectored vaccine, which is live. But unlike the varicella vaccine, the vector is replication-deficient. It cannot make copies, it's just a delivery vehicle for SARS-CoV-2 antigens. Thus no potential for persistent infection.

        2 replies 4 retweets 45 likes
        Show this thread
      11. Edward Nirenberg‏ @ENirenberg 1 Dec 2020

        Taken together, these things suggest that concerns about some latent, long-term consequence of these vaccines are vastly overstated. We have every reason to believe that these vaccines will be safe and effective, and in a pandemic, we can't always have perfect information.

        1 reply 1 retweet 36 likes
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      12. Edward Nirenberg‏ @ENirenberg 1 Dec 2020

        It would be excellent if we could track the study participants for years- and we are. Even though the mRNA vaccines have met their efficacy endpoints and are filing for EUA, participants will be followed for 2 years to document any potential issues related to the vaccine.

        2 replies 0 retweets 27 likes
        Show this thread
      13. Edward Nirenberg‏ @ENirenberg 1 Dec 2020

        But right now there are people being sickened by COVID-19, dying, and facing profound disability and our healthcare system is stretched very thin. These concerns don't have a good scientific basis, and right now, waiting longer than necessary to validate them is a big risk.

        3 replies 1 retweet 41 likes
        Show this thread
      14. End of conversation

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