.@WHO's @DrMikeRyan — who knows a lot more about infectious diseases than I do — thinks it's not too late to stop #2019nCoV. Learned some interesting stuff talking to him today.https://www.statnews.com/2020/02/01/top-who-official-says-not-too-late-to-stop-coronavirus-outbreak/ …
Dr Ryan notes preponderance of male deaths from 2019nCoV. Authors of recent Lancet paper also saw this & speculated female hormones/ immune effects might play role. But might high smoking rates in men (>50%) vs women (<5%) in region also be relevant? Thru several mechanisms..
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I actually wondered the same thing about smokers when I saw the lancet paper... but I think this is the sort of thing we’ll only be able to parse out once it’s all over.
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Asked about it yesterday. At present there aren't data available with which to draw informed conclusions on whether there's a link between smoking and severe disease.
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Or, perhaps more wet market vendors were male? First cases mostly from the market, may change as hits general population?
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A lot of fatalities beyond the 45 or so market cases and apparently the male bias still holds.
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Speculation: PM2.5 air pollution might also have an effect. PM2.5 pollution is bad across a lot of China. Might this have an effect on the relative severity of cases both across ages and inside China and outside China? Testable?
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The “wet market” cohort is a skewed sample to older males because of the place: most of the people there are older males. A recent pre-print has a less skewed demographic (but still some excess males).https://twitter.com/kevinpurcell/status/1224033362345508864?s=21 …
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Do you happen to have a link to his findings? I'm very curious about this...
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not a scientist, but I did stumble across a paper that claims to show male mice more susceptible to SARS: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450662/ … paper suggests difference is due to estrogen signaling. doesn't rule out smoking having an effect, of course, but hormones seems more supported
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Seems so. 'In general, males generate less robust immune responses and are more susceptible to a variety of infectious agents (23-27). In contrast, females mount stronger innate and adaptive immune responses and are relatively resistant to virus infections (23, 28-30)'
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damaged lungs from prolonged exposure to terrible air quality also needs to be taken into account.
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Čini se da učitavanje traje već neko vrijeme.
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