Thomas Dayspring

@Drlipid

MD, FACP, FNLA - Clinical Lipidologist: Tweets/Re-Tweets do not represent endorsements/medical advice

Richmond, VA
Vrijeme pridruživanja: srpanj 2009.

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  2. prije 19 sati

    Trial planned to help settle the debate over using Keto Diet with T2D

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  3. 3. velj

    Not good for lipid/CV care: Insured adults have been visiting PCPs less often & nearly 1/2 had no PCP visits in a given year by 2016. This decline may be explained by decreased/perceived visit needs, $$ deterrents & use of alternative care.

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  4. 3. velj

    NOT REALLY DEBATABLE - For each 39mg/dL (1mmol/L) LDLc lowering, the RR of MACE is independent of the starting LDLc or presence of DM or CKD. Pts at lower CV risk & younger age might have a similar relative reduction in risk with LDLc lowering therapies

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    3. velj
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    GRADE guidelines 27: how to calculate absolute effects for time-to-event outcomes in summary of findings tables and Evidence Profiles

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  7. 1. velj

    On top of all the nightmare issues raised by re generics, now read about the issues pharmacists dispensing the drugs face

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  8. 1. velj

    A strikingly high proportion of FH subjects (40%) lacked mutations in known culprit genes. Mutation(-) pts were older (mean 49 vs 57), & had more African Americans (1% vs 12.5%), more HTN (21% vs 46%) & inc TG (median 86 mg/dL vs 122 mg/dL) levels.

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  9. 31. sij

    More evidence there is little to worry about when appropriately reducing LDL metrics for CV benefit.

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  10. 31. sij

    CLICK TO ENLARGE - With respect to choelsterol homeostasis: a good place to start your learning curve is serious study of the membrane sterol infux/export transporters at gut/enterocyte and hepatobiliary interfaces -

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    31. sij

    Recognition & Treatment of by Primary Care Physicians: Survey from shows need for more education in recognizing & treating HoFH, greater access to lipid specialists & LDL-apheresis

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  12. 30. sij

    CLICK TO ENLARGE - To understand sterol (meaning cholesterol and xenosteols) absorption/homeostasis you will need to maste the functions of several hepatic and enterocytic receptors

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  13. 30. sij

    CLICK TO ENLARGE - Intestinal Cholesterol Absorption

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    29. sij

    New triglyceride-lowering therapy alert! A dual apoC-II mimetic–apoC-III antagonist peptide promotes lipolysis and lowers plasma triglycerides

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  15. 29. sij

    Hypothesis: With respect to eggs and cholesterol homeostasis - Daily intake might differently affect sterol hyper-absorbers compared to those with normo-absorption or hypo-absorbers: related to gain or or loss of function of sterol influx/efflux transporters (NPC1L1 or ABCG5/G8)

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  16. 29. sij

    If needed beyond lifestyle to achieve desired (and individualized) HgbA1c goals the FDA has approved : a three in one therapy (called Trijardy XR) for management of T2D. Added to metformin is an SGLT2i (empaglifozin) & a DPP4i (linagliptin)

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  17. 29. sij

    No association of Egg Intake (≥7 egg/wk compared with <1 egg/wk intake) with blood lipids, CVD, and mortality in 177,000 People in 50 Countries

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  18. 28. sij

    Clinical trials of high doses of vitamin D are not finding the benefits that some advocates had promoted and are even hinting at some adverse effects.

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  19. 27. sij

    CAD & its consequences remain the leading causes of premature death and lifelong disability in most countries: Read - Stable ischemic heart disease: how to keep it that way

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  20. 27. sij

    Listen to the "Codfather" - Dr Bill Harris briefly explain why all should get their Omega-3 Index checked. The test is a steady state, erythrocyte phospholipid-omega 3 metric which should not be confused with the variable plasma (serum) omega 3 test

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