Siddhartha MukherjeeOvjeren akaunt

@DrSidMukherjee

Cancer physician, researcher. The Emperor of All Maladies: winner of Pulitzer Prize 2011. The GENE. Columbia Asst Professor. Stem cell biologist. New Yorker !

Vrijeme pridruživanja: srpanj 2010.

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  1. Delighted, delighted to announce that the immuneel GMP facility— to make cell therapies and viruses for human use — opened yesterday. What a proud moment for India and for medicine ... here are the pioneer virologists, doctors, cell therapists and investors !!!

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  2. Enzo was my friend and mentor at Oxford. I spoke with him every day. He taught me how to immunize mice; how to write a paper; how to make vaccinia virus; how to think about immunology. It is a terrible loss to me, and to science at large. I miss him so much !!

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  4. This is a balanced history... read it. Drug prices are dangerously out of control, but the debate about how to control them PRAGMATICALLY seems out of whack as well. wrothttps://www.statnews.com/2019/12/23/debate-over-us-drug-pricing-system-time-to-face-reality/

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  5. And I promise to compile a master list. Seed and soil, yes. Clonal mutations in "normal" tissues, yes. Lifestyle, yes. Metabolism. New anti-cancer drugs.

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  6. I am in the process of adding 2-3 chapters to The Emperor of All Maladies for 2020. So twitterati.. what should absolutely be included in prevention, detection and treatment? Obviously, immunotherapy, the role of obesity, the success of HPV vaccines. Other major thoughts ?

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  7. So so so honored to be among the Guardians 100 most influential books of the 21st century. Wow. And at #32, Emperor even made it to the top 50.

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  8. proslijedio/la je Tweet
    21. ruj 2019.

    released its 100 best book of the 21st century today. Dig into our in-depth interviews with all of these pioneers

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  9. Very proud of Jian Zhang and our amazing team (Jim Manley, Abdullah Ali, Yen Lieu, Azra Raza) in deciphering how mutations in RNA splicing genes (Sf3b1) cause changes in the splice site. Many implications for blood cancers.

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  10. Vor is growing ! We were joined by Robert Ang, and are slowly wrapping our heads around a pivotal clinical study with CRISPR in human stem cells !

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  11. My full interview with on genetic engineering of humans, and our new study to cure cancer (AML) with gene editing and Crispr

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  12. proslijedio/la je Tweet

    Here's the full interview with arguiing that genetically engineered therapies might brush back cancer soon via

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  13. Long and detailed conversation with Walter Isaacson on Crispr, my piece in the New Yorker and our latest research in PNAS (gene editing in human cord blood stem cells to cure AML) awaiting human trials

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  14. At this point, a larger question arises: What is a drug, anyway? A therapeutic substance. But does it have to be a molecule in its pure form, like aspirin ? Are "living cells" drugs ? And can we afford them ? Will they drive us bankrupt ?

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  15. We don’t entirely know how to regulate, or even conceptualize of, this new generation of cellular drugs. Should the irreversible alteration of a body be governed by different rules? If your cells are being genetically modified and reinfused into you, who should we say owns them?

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  16. But as doctors, as medical scientists and inventors, we are taught to think about curing deadly diseases or about creating new systems of care. We want to battle the mortal coil, not the plastic coil.”

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  17. From the first bone marrow transplants to CAR-t therapies ... an incredible scientific legacy. But can we afford these new treatments ? Are they really drugs ? My latest in the New Yorker

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  18. Sometimes you read your own work and relive an experience. I had almost forgotten that I had written this. I relived that night, the 1 am phonecall, and the fateful fever

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  19. Fascinating and intriguing article on AI for personalized diets by "Now the central flaw in the whole premise is becoming clear: the idea that there is one optimal diet for all people."

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  20. This describes our new anti leukemia cellular drug in simpler terms. Of course, if you want to read the paper it’s in pnas

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