4) “The treatment groups included 1868 patients who were given chloroquine alone, 3016 given hydroxychloro- quine alone, 3783 given chloroquine w/ macrolide and 6221 given hydroxychloroquine and macrolide. The median time from hospitalisation to diagnosis of COVID-19 was 2 days.
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15) In appendix, they also present results of a COMPOSITE endpoint if either mechanical ventilation or death (whichever came first in the Cox PH analysis). Results mostly same as the mortality endpoint, and even moderately stronger than death alone.pic.twitter.com/59P42Ncp82
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16) Other risk factors that stand out for higher risk of death:
Men
Adiposity (BMI)
Blacks and Hispanics vs White
Heart disease
Diabetes
Hypertension
High cholesterol
Smoking

Non-users of ACE inhibitor*

Non-users of statins*
*Neat but need confirmation.pic.twitter.com/XMUIglGTwt
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17) the strong findings of lower risk death for ACE inhibitors and statin users is interesting. But they area already drugs that are well known to lower risk of death. But do they lower even more among COVID patients? Unclear.
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18) And racial data, I don’t want to overinterpret yet, because I don’t know if Blacks in Africa should be compared to whites in US/Europe. Prefer data on African Americans vs Whites in NA & African Europeans vs Whites in Europe w/in any continent. Same for Asians and Hispanics.
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19) BOTTOMLINE: this study demonstrating CQ & HCQ increasing risk of death is an epic body of work representing amazing collaboration of 671 hospitals. Though not trial, it’s hospital registry data that is quite strong longitudinal design.
Do NOT take HCQ or CQ at this time!Show this thread
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It’s almost like somebody doesn’t want people to know that zinc is helpful. I wonder why that is?
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Can we have the list of hospitals that collaborated in the study? They are not described not even in ackowledgements.
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Amazing indeed
What a coïncidence such a degree of homogeneity !https://twitter.com/raoult_didier/status/1265291857866764288?s=19 …
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