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DrEricDing's profile
Eric Feigl-Ding
Eric Feigl-Ding
Eric Feigl-Ding
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@DrEricDing

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Eric Feigl-DingVerified account

@DrEricDing

Epidemiologist & health economist. Senior Fellow @FAScientists. Former 16 years @Harvard. @JohnsHopkins alum. COVID updates since Jan '20: http://nym.ag/3olszuo 

Washington DC & Virginia
fas.org/expert/eric-fe…
Joined January 2009

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    1. Eric Feigl-Ding‏Verified account @DrEricDing 22 May 2020

      4) “The treatment groups included 1868 patients who were given chloroquine alone, 3016 given hydroxychloro- quine alone, 3783 given chloroquine w/ macrolide and 6221 given hydroxychloroquine and macrolide. The median time from hospitalisation to diagnosis of COVID-19 was 2 days.

      12 replies 112 retweets 406 likes
      Show this thread
    2. Eric Feigl-Ding‏Verified account @DrEricDing 22 May 2020

      5) “The mean daily dose and duration: chloroquine alone, 765 mg (SD 308) and 6·6 days (2·4); hydroxychloroquine alone, 596 mg (126) and 4·2 days (1·9); chloroquine w/ macrolide, 790 mg (320) and 6·8 days (2·5); and hydroxychloroquine w/ macrolide, 597 mg (128) and 4·3 days (2·0)”

      9 replies 97 retweets 334 likes
      Show this thread
    3. Eric Feigl-Ding‏Verified account @DrEricDing 22 May 2020

      6) “No significant between-group differences were found among baseline characteristics or comorbidities.” ➡️THIS IS QUITE REMARKABLE. Balanced means no baseline confounding. Akin to what you might see in a trial usually, except it wasn’t. Very reassuring.pic.twitter.com/ITMJcnzQ1z

      12 replies 115 retweets 404 likes
      Show this thread
    4. Eric Feigl-Ding‏Verified account @DrEricDing 22 May 2020

      7) “Analyses using propensity score matching by treatment group... indicated that associations between drug regimens and mortality, need for mechanical ventilation, length of stay, and the occurrence of de-novo ventricular arrhythmias were consistent with the primary analysis.”

      2 replies 86 retweets 301 likes
      Show this thread
    5. Eric Feigl-Ding‏Verified account @DrEricDing 22 May 2020

      8) “David Maron, director of preventive cardiology at the Stanford University School of Medicine, said that “these findings provide absolutely no reason for optimism that these drugs might be useful in the prevention or treatment of covid-19.”

      8 replies 139 retweets 403 likes
      Show this thread
    6. Eric Feigl-Ding‏Verified account @DrEricDing 22 May 2020

      9) Nearly 15,000 of the 96,000 patients in the analysis were treated with hydroxychloroquine or chloroquine alone or in combination with a type of antibiotics known as a macrolide, such as azithromycin, within 48 hours of their diagnosis.

      7 replies 88 retweets 298 likes
      Show this thread
    7. Eric Feigl-Ding‏Verified account @DrEricDing 22 May 2020

      10) The mean age was 54 years, and 53 percent were men. Those who were on mechanical ventilators or who received remdesivir, an antiviral drug made by Gilead Sciences that has shown promise in decreasing recovery times, were excluded.

      2 replies 83 retweets 316 likes
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    8. Eric Feigl-Ding‏Verified account @DrEricDing 22 May 2020

      11) For those given hydroxychloroquine, there was 34% increase in risk of mortality & 137% increased risk of serious heart arrhythmias. For those receiving hydroxychloroquine +antibiotic — there was 45% increased risk of death & 411% increased risk of serious heart arrhythmias.

      19 replies 222 retweets 456 likes
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    9. Eric Feigl-Ding‏Verified account @DrEricDing 22 May 2020

      12) “Those given chloroquine had a 37% increased risk of death and a 256% increased risk of serious heart arrhythmias. For those taking chloroquine and an antibiotic, there was a 37% increased risk of death and a 301% increased risk of serious heart arrhythmias.”

      18 replies 180 retweets 393 likes
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    10. Eric Feigl-Ding‏Verified account @DrEricDing 22 May 2020

      13) Clarification of “increased risk” nomenclature: hazard ratio of 5.0 denotes “inc risk by 5x” (drug user risk = 5*non user risk), or can also be described as a “400% increased risk of outcome”. In 1st post, I used the 5x language, which is same as 400% inc risk of X language.

      5 replies 75 retweets 255 likes
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      Eric Feigl-Ding‏Verified account @DrEricDing 22 May 2020

      14) Amazing that data came together from 671 hospitals across 6 continents!pic.twitter.com/znerDGeFgA

      6:38 AM - 22 May 2020
      • 131 Retweets
      • 353 Likes
      • SilentConqueror Jeff Friedman Up North Kayak hunter klapperich Adrian Ray Ore Carmi KellyR 🌊❤🐾🌎 Santánico Pandemónium paravola
      13 replies 131 retweets 353 likes
        1. New conversation
        2. Eric Feigl-Ding‏Verified account @DrEricDing 22 May 2020

          15) In appendix, they also present results of a COMPOSITE endpoint if either mechanical ventilation or death (whichever came first in the Cox PH analysis). Results mostly same as the mortality endpoint, and even moderately stronger than death alone.pic.twitter.com/59P42Ncp82

          6 replies 65 retweets 238 likes
          Show this thread
        3. Eric Feigl-Ding‏Verified account @DrEricDing 22 May 2020

          16) Other risk factors that stand out for higher risk of death: 📌Men 📌Adiposity (BMI) 📌Blacks and Hispanics vs White 📌Heart disease 📌Diabetes 📌Hypertension 📌High cholesterol 📌Smoking 📌⚠️Non-users of ACE inhibitor* 🔥⚠️Non-users of statins* *Neat but need confirmation.pic.twitter.com/XMUIglGTwt

          12 replies 138 retweets 324 likes
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        4. Eric Feigl-Ding‏Verified account @DrEricDing 22 May 2020

          17) the strong findings of lower risk death for ACE inhibitors and statin users is interesting. But they area already drugs that are well known to lower risk of death. But do they lower even more among COVID patients? Unclear.

          7 replies 75 retweets 249 likes
          Show this thread
        5. Eric Feigl-Ding‏Verified account @DrEricDing 22 May 2020

          18) And racial data, I don’t want to overinterpret yet, because I don’t know if Blacks in Africa should be compared to whites in US/Europe. Prefer data on African Americans vs Whites in NA & African Europeans vs Whites in Europe w/in any continent. Same for Asians and Hispanics.

          7 replies 51 retweets 217 likes
          Show this thread
        6. Eric Feigl-Ding‏Verified account @DrEricDing 22 May 2020

          19) BOTTOMLINE: this study demonstrating CQ & HCQ increasing risk of death is an epic body of work representing amazing collaboration of 671 hospitals. Though not trial, it’s hospital registry data that is quite strong longitudinal design. ➡️ Do NOT take HCQ or CQ at this time!

          23 replies 141 retweets 395 likes
          Show this thread
        7. End of conversation
        1. Nationalism is Patriotism‏ @MiloWear1A 23 May 2020
          Replying to @DrEricDing

          It’s almost like somebody doesn’t want people to know that zinc is helpful. I wonder why that is?

          0 replies 0 retweets 1 like
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        1. Maria Ninguém‏ @marianinguem61 26 May 2020
          Replying to @DrEricDing @surgisphere

          Can we have the list of hospitals that collaborated in the study? They are not described not even in ackowledgements.

          0 replies 0 retweets 1 like
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        1.  🌿 Capalu  🌿 Aka Untribium Agent132‏ @capalutwit 27 May 2020
          Replying to @DrEricDing

           🌿 Capalu  🌿 Aka Untribium Agent132 Retweeted Didier Raoult

          Amazing indeed 🙄 🙃 What a coïncidence such a degree of homogeneity !https://twitter.com/raoult_didier/status/1265291857866764288?s=19 …

           🌿 Capalu  🌿 Aka Untribium Agent132 added,

          Didier RaoultVerified account @raoult_didier
          About the paper published in The Lancet: data coming from five different continents cannot be so homogeneous. There is either data manipulation (not mentionned in Material and Methodes), or incorporation of faked data. pic.twitter.com/Oda45XA9B5
          0 replies 0 retweets 1 like
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