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DrEricDing's profile
Eric Feigl-Ding
Eric Feigl-Ding
Eric Feigl-Ding
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@DrEricDing

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Eric Feigl-DingVerified account

@DrEricDing

Epidemiologist & health economist. Senior Fellow, @FAScientists. Former 16 yrs @Harvard. @JohnsHopkins alum. Health & social justice. COVID updates since Jan’20

Washington DC & Virginia
fas.org/expert/eric-fe…
Joined January 2009

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    1. Eric Feigl-Ding‏Verified account @DrEricDing 27 Jan 2020

      “Where did the 🦠 come from?” is one of the most asked questions. First, I don’t like unsupported conspiracy theories, but it’s a lingering question. @sciencemagazine examined this based on Lancet article. Nobody knows, but seafood market isn’t whole storyhttps://www.sciencemag.org/news/2020/01/wuhan-seafood-market-may-not-be-source-novel-virus-spreading-globally …

      257 replies 3,036 retweets 4,701 likes
      Show this thread
    2. Eric Feigl-Ding‏Verified account @DrEricDing 27 Jan 2020

      2. Again, no outright conspiracy theories please. Here is another explanation: The new #coronavirus is an RNA virus—that is, viruses that have RNA as their genetic material rather than DNA—which have a “high mutation rate,” which allows it to “change properties very quickly.”

      23 replies 393 retweets 1,034 likes
      Show this thread
    3. Eric Feigl-Ding‏Verified account @DrEricDing 27 Jan 2020

      3. The RNA sequences of the #coronavirus isolated from 6 patients from the same household are different from each other (Lancet), sign of the virus evolving. This may not be so good to the ear; it suggests the difficulty of containing this virus”. (from https://m.theepochtimes.com/china-underreporting-true-scale-of-deadly-viral-outbreak-expert-says_3218207.html …)

      55 replies 826 retweets 1,307 likes
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    4. Eric Feigl-Ding‏Verified account @DrEricDing 27 Jan 2020

      4. DEEPER DIVE into #coronavirus RNA genome 🧬, here goes... “it came from bats 🦇” is often heard, but it’s trickier. The 🦠 has similarities to bat coronavirus, but this new paper REJECTS there was recent recombination. There is something discordant too:https://www.biorxiv.org/content/10.1101/2020.01.26.920249v1 …

      16 replies 336 retweets 801 likes
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    5. Eric Feigl-Ding‏Verified account @DrEricDing 27 Jan 2020

      5. (Continued from above)... “A BLAST search of 2019-nCoV middle fragment revealed no considerable similarity with any of the previously characterized corona viruses (figure 2)” —> it’s a sequence entirely new to any known #coronavirus. What does this mean? We don’t know yet.

      20 replies 269 retweets 752 likes
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    6. Eric Feigl-Ding‏Verified account @DrEricDing 27 Jan 2020

      6. “Notably, the new coronavirus provides a new lineage for almost half of its genome, with no close genetic relationships to other viruses within the subgenus of sarbecovirus.” —> basically it’s saying it’s completely brand new to #coronavirus subgenus.

      16 replies 354 retweets 849 likes
      Show this thread
    7. Eric Feigl-Ding‏Verified account @DrEricDing 27 Jan 2020

      7. Very strange: So what is in this new mystery middle segment that has no #coronavirus history? The study authors continue: “This genomic part comprises also half of the spike region encoding a multifunctional protein responsible also for virus entry into host cells[30,31]”.🤔

      24 replies 276 retweets 698 likes
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    8. Eric Feigl-Ding‏Verified account @DrEricDing 27 Jan 2020

      8. Continuing: “Our study rejects the hypothesis of emergence as a result of a recent recombination event.”—> I.e. the authors also conclude that the new #coronavirus did not originate from random recent admixture between different coronaviruses. Other possibilities of course.

      15 replies 224 retweets 621 likes
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      Eric Feigl-Ding‏Verified account @DrEricDing 27 Jan 2020

      9. BOTTOMLINE: 1) Seafood market not the source. 2) This RNA #coronavirus mutates really fast. 3) 🧬 has unusual middle segment never seen before in any coronavirus. 4) Not from recent mixing. 5) That mystery middle segment encodes protein responsible for entry into host cells.

      8:15 PM - 27 Jan 2020
      • 1,536 Retweets
      • 2,577 Likes
      • Steph EdWeirdo MACARIN 🅹🅴🅽🅽🅸🅵🅴🆁 🆆🅸🅻🅻🅸🅰🅼🆂 👄 scibib 🏳️‍🌈🇪🇺 #CovidElimination Isabella Gunadasa Molly Walton nudes.exe ❁ oeuf 👋🏻O
      108 replies 1,536 retweets 2,577 likes
        1. New conversation
        2. Eric Feigl-Ding‏Verified account @DrEricDing 27 Jan 2020

          10. TO BE CLEAR: I am absolutely not saying it’s bioengineering, nor am I supporting any conspiracy theories with no evidence. I’m simply saying scientists need to do more research + get more data. And finding the origin of the virus is an important research priority. Goodnight😴pic.twitter.com/N4Yp2H8Tst

          119 replies 381 retweets 1,424 likes
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        3. Eric Feigl-Ding‏Verified account @DrEricDing 29 Jan 2020

          11. Dubbing this the [GENETIC THREAD] 🧬 thread, let’s delve back into the genetic similarities of the new 🦠 with SARS and bat #coronaviruses. Study in Lancet says ~88% related to closest bat coronavirus, 79% to SARS (which is more than humans-elephants) https://marlin-prod.literatumonline.com/pb-assets/Lancet/pdfs/S0140673620302518.pdf …pic.twitter.com/2568DtbsoJ

          6 replies 139 retweets 315 likes
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        4. Eric Feigl-Ding‏Verified account @DrEricDing 29 Jan 2020

          12. ...As you can see, the new nCOV is a branch off the bat coronavirus subgenus. It is too distant from SARS (79%) or MERS (only 50% related)pic.twitter.com/A3nxtwt7Jh

          10 replies 199 retweets 455 likes
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        5. Eric Feigl-Ding‏Verified account @DrEricDing 29 Jan 2020

          13. For the most part, the new #coronavirus shares 87-88% overlap with bat coronavirus. But there are parts of it like the “S” gene 🧬 region where I drops to ~70%, and even 68% in lowest point. But other gene regions share 🧬 consensus as high as 95%.pic.twitter.com/XrIQOfgSOQ

          30 replies 187 retweets 410 likes
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        6. Eric Feigl-Ding‏Verified account @DrEricDing 29 Jan 2020

          14. What is in the “S” 🧬 region of the #coronavirus? According to the Lancet piece (link 🧵 above), it encodes the virus envelop spike protein of the 🦠 for binding receptors of host cells - “crucial for host tropism” — which basically identifies how to target 🎯 host tissue.pic.twitter.com/rtqjDrtRgw

          18 replies 127 retweets 336 likes
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        7. Eric Feigl-Ding‏Verified account @DrEricDing 29 Jan 2020

          15. One source or many sources? The mutation rate suggests the 2019-nCoV came from just one recent source in single jump (as opposed to several mutation sources). This doesn’t mean much other than it wasn’t several strains that started outbreak. Don’t over-interpret. Just FYI.pic.twitter.com/utEN7O4krg

          24 replies 149 retweets 388 likes
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        8. End of conversation
        1. David A‏ @David1919A 27 Jan 2020
          Replying to @DrEricDing

          Conclusión?

          2 replies 0 retweets 2 likes
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        2. The Trinity God‏ @MnguniReymon 27 Jan 2020
          Replying to @tiresomekabuki @DrEricDing

          So you think they made the virus 🦠, if so for what purpose

          3 replies 0 retweets 1 like
        3. Show replies
        1. New conversation
        2. The Circular Critique‏ @TheCircularCri1 27 Jan 2020
          Replying to @DrEricDing

          @DrEricDing can we expect it will take longer for antidote/vaccine as a result of mystery middle segment? Or simply that will spread fast due to encoded protein responsible for entry into host cells?

          2 replies 4 retweets 22 likes
        3. The Circular Critique‏ @TheCircularCri1 27 Jan 2020
          Replying to @TheCircularCri1 @DrEricDing

          Also thank you for your educated opinion/info and transparency.

          0 replies 0 retweets 11 likes
        4. End of conversation

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