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Eric Feigl-Ding
Eric Feigl-Ding
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Eric Feigl-Ding

@DrEricDing

Public health scientist👨🏻‍🔬/ Epidemiologist / Health Economist / Harvard ‘07 + Johns Hopkins ‘04 / Taught 15yrs HarvardSPH / NYT-feat. pharma whistleblower

VA & Washington DC
scholar.harvard.edu/ericding
Vrijeme pridruživanja: siječanj 2009.

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    Eric Feigl-Ding‏ @DrEricDing 28. sij
    • Prijavi Tweet

    “Where did the 🦠 come from?” is one of the most asked questions. First, I don’t like unsupported conspiracy theories, but it’s a lingering question. @sciencemagazine examined this based on Lancet article. Nobody knows, but seafood market isn’t whole storyhttps://www.sciencemag.org/news/2020/01/wuhan-seafood-market-may-not-be-source-novel-virus-spreading-globally …

    18:57 - 27. sij 2020.
    • 3.821 proslijeđeni Tweet
    • 5.675 oznaka „sviđa mi se”
    • Alroy Slayer of Dragons Augustus S. Pee (aka 王巴担 Wang Badan) Dunk WuhanGonnaGetUs Patrick Cadogan SUN@機工城SUN天動編 Juel Braganza Sara Lopez M.
    3.821 proslijeđeni tweet 5.675 korisnika označava da im se sviđa
      1. Novi razgovor
      2. Eric Feigl-Ding‏ @DrEricDing 28. sij
        • Prijavi Tweet

        2. Again, no outright conspiracy theories please. Here is another explanation: The new #coronavirus is an RNA virus—that is, viruses that have RNA as their genetic material rather than DNA—which have a “high mutation rate,” which allows it to “change properties very quickly.”

        27 replies 540 proslijeđenih tweetova 1.296 korisnika označava da im se sviđa
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      3. Eric Feigl-Ding‏ @DrEricDing 28. sij
        • Prijavi Tweet

        3. The RNA sequences of the #coronavirus isolated from 6 patients from the same household are different from each other (Lancet), sign of the virus evolving. This may not be so good to the ear; it suggests the difficulty of containing this virus”. (from https://m.theepochtimes.com/china-underreporting-true-scale-of-deadly-viral-outbreak-expert-says_3218207.html …)

        1.106 proslijeđenih tweetova 1.630 korisnika označava da im se sviđa
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      4. Eric Feigl-Ding‏ @DrEricDing 28. sij
        • Prijavi Tweet

        4. DEEPER DIVE into #coronavirus RNA genome 🧬, here goes... “it came from bats 🦇” is often heard, but it’s trickier. The 🦠 has similarities to bat coronavirus, but this new paper REJECTS there was recent recombination. There is something discordant too:https://www.biorxiv.org/content/10.1101/2020.01.26.920249v1 …

        19 replies 457 proslijeđenih tweetova 997 korisnika označava da im se sviđa
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      5. Eric Feigl-Ding‏ @DrEricDing 28. sij
        • Prijavi Tweet

        5. (Continued from above)... “A BLAST search of 2019-nCoV middle fragment revealed no considerable similarity with any of the previously characterized corona viruses (figure 2)” —> it’s a sequence entirely new to any known #coronavirus. What does this mean? We don’t know yet.

        370 proslijeđenih tweetova 947 korisnika označava da im se sviđa
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      6. Eric Feigl-Ding‏ @DrEricDing 28. sij
        • Prijavi Tweet

        6. “Notably, the new coronavirus provides a new lineage for almost half of its genome, with no close genetic relationships to other viruses within the subgenus of sarbecovirus.” —> basically it’s saying it’s completely brand new to #coronavirus subgenus.

        15 replies 481 proslijeđeni tweet 1.084 korisnika označavaju da im se sviđa
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      7. Eric Feigl-Ding‏ @DrEricDing 28. sij
        • Prijavi Tweet

        7. Very strange: So what is in this new mystery middle segment that has no #coronavirus history? The study authors continue: “This genomic part comprises also half of the spike region encoding a multifunctional protein responsible also for virus entry into host cells[30,31]”.🤔

        29 replies 377 proslijeđenih tweetova 892 korisnika označavaju da im se sviđa
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      8. Eric Feigl-Ding‏ @DrEricDing 28. sij
        • Prijavi Tweet

        8. Continuing: “Our study rejects the hypothesis of emergence as a result of a recent recombination event.”—> I.e. the authors also conclude that the new #coronavirus did not originate from random recent admixture between different coronaviruses. Other possibilities of course.

        18 replies 308 proslijeđenih tweetova 821 korisnik označava da mu se sviđa
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      9. Eric Feigl-Ding‏ @DrEricDing 28. sij
        • Prijavi Tweet

        9. BOTTOMLINE: 1) Seafood market not the source. 2) This RNA #coronavirus mutates really fast. 3) 🧬 has unusual middle segment never seen before in any coronavirus. 4) Not from recent mixing. 5) That mystery middle segment encodes protein responsible for entry into host cells.

        119 replies 1.944 proslijeđena tweeta 3.048 korisnika označava da im se sviđa
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      10. Eric Feigl-Ding‏ @DrEricDing 28. sij
        • Prijavi Tweet

        10. TO BE CLEAR: I am absolutely not saying it’s bioengineering, nor am I supporting any conspiracy theories with no evidence. I’m simply saying scientists need to do more research + get more data. And finding the origin of the virus is an important research priority. Goodnight😴pic.twitter.com/N4Yp2H8Tst

        137 replies 512 proslijeđenih tweetova 1.757 korisnika označava da im se sviđa
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      11. Eric Feigl-Ding‏ @DrEricDing 29. sij
        • Prijavi Tweet

        11. Dubbing this the [GENETIC THREAD] 🧬 thread, let’s delve back into the genetic similarities of the new 🦠 with SARS and bat #coronaviruses. Study in Lancet says ~88% related to closest bat coronavirus, 79% to SARS (which is more than humans-elephants) https://marlin-prod.literatumonline.com/pb-assets/Lancet/pdfs/S0140673620302518.pdf …pic.twitter.com/2568DtbsoJ

        6 replies 181 proslijeđeni tweet 409 korisnika označava da im se sviđa
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      12. Eric Feigl-Ding‏ @DrEricDing 29. sij
        • Prijavi Tweet

        12. ...As you can see, the new nCOV is a branch off the bat coronavirus subgenus. It is too distant from SARS (79%) or MERS (only 50% related)pic.twitter.com/A3nxtwt7Jh

        9 replies 262 proslijeđena tweeta 584 korisnika označavaju da im se sviđa
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      13. Eric Feigl-Ding‏ @DrEricDing 29. sij
        • Prijavi Tweet

        13. For the most part, the new #coronavirus shares 87-88% overlap with bat coronavirus. But there are parts of it like the “S” gene 🧬 region where I drops to ~70%, and even 68% in lowest point. But other gene regions share 🧬 consensus as high as 95%.pic.twitter.com/XrIQOfgSOQ

        37 replies 229 proslijeđenih tweetova 526 korisnika označava da im se sviđa
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      14. Eric Feigl-Ding‏ @DrEricDing 30. sij
        • Prijavi Tweet

        14. What is in the “S” 🧬 region of the #coronavirus? According to the Lancet piece (link 🧵 above), it encodes the virus envelop spike protein of the 🦠 for binding receptors of host cells - “crucial for host tropism” — which basically identifies how to target 🎯 host tissue.pic.twitter.com/rtqjDrtRgw

        20 replies 166 proslijeđenih tweetova 439 korisnika označava da im se sviđa
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      15. Eric Feigl-Ding‏ @DrEricDing 30. sij
        • Prijavi Tweet

        15. One source or many sources? The mutation rate suggests the 2019-nCoV came from just one recent source in single jump (as opposed to several mutation sources). This doesn’t mean much other than it wasn’t several strains that started outbreak. Don’t over-interpret. Just FYI.pic.twitter.com/utEN7O4krg

        190 proslijeđenih tweetova 480 korisnika označava da im se sviđa
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