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Nature Reviews Disease Primers publishes Primers - introductory reviews on diseases and disorders - across all medical specialties. Check back each week!

Vrijeme pridruživanja: listopad 2014.

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  1. Prikvačeni tweet

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  2. Nausea and vomiting of and its severe form, hyperemesis gravidarum, are associated with extreme reduction in quality of life.

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  3. In addition to enlargement of the extremities and facial features, many other comorbidities and complications occur in patients with , and the presence of a tumour can result in local effects on surrounding tissues.

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  4. Cancer-associated surgery and can result in the development of , which can severely impair the quality of life of patients and survivors.

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  5. Preclinical studies have revealed various targetable pathways in that may optimize available therapies or overcome resistance to available drugs.

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  6. The two histological subtypes of , adamantinomatous (ACP) and papillary (PCP), differ in their age distribution: ACPs affect all age groups and are the more common subtype, whereas PCPs are mostly restricted to adults.

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  7. Comprehensive epigenome profiling has revealed that EWSR1–FLI1 (a fusion protein common in ) drives widespread epigenetic reprogramming.

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  9. Cartilage damage and bone erosion are the cardinal signs of , a chronic inflammatory joint disease of nature.

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  10. Ahead of , get Primed on , which occur in approximately 20% of patients with cancer.

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  11. The heritability of is estimated to be up to 85%, although a multifactorial model of gene–environment interaction is believed to best fit this disorder.

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  12. In the management of ST-segment elevation , it is essential that reperfusion therapy (which aims to restore blood flow in the occluded coronary artery) is performed as soon as possible.

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  13. Methicillin-resistant Staphylococcus aureus () bacteria can cause severe , in particular in health-care settings.

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  14. Epidermal barrier abnormalities and T cell-driven skin are the pathological mechanisms underlying , and dysbiosis of the skin could also have a role.

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  15. Alterations in several domains of quality of life are associated with disorder, including financial, social, physical and mental health.

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  16. C virus is the aetiologic agent of in most patients. The underlying mechanism of cryoglobulinaemia is B cell lymphoproliferation and autoantibody production.

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  17. Alcoholic can be caused by the chronic consumption of exceeding a certain daily amount, which varies considerably between individuals.

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  18. Impoverished populations living in the rural tropics are particularly vulnerable to envenoming, which kills >100,000 people, maims >400,000 people every year and perpetuates the cycle of poverty.

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  19. are soil-transmitted helminths; these parasites can survive and multiply in the small intestine for years and feed on the host's blood.

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  20. It has been estimated that someone dies from in a rabies-endemic country every 10–20 minutes and that 40–50% of fatalities are in children of <15 years of age.

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  21. On , get Primed on , an infection caused by parasitic flatworms (blood flukes).

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