Aren't there studies on promiscuous rodents (rats and hamsters, I think) showing that first sex also sensitizes rodents to amphetamine ? In contrast, pair-bonding voles used less alcohol when bonded than when single. I found this article with some links:https://www.yourbrainonporn.com/pair-bonding-101-beware-novelty-as-aphrodisiac …
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Isn't that also true of depression?
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