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Profil korisnika/ce DavidSteensma
David Steensma
David Steensma
David Steensma
@DavidSteensma

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David Steensma

@DavidSteensma

Hematologist-oncologist in Boston, focused on clinical research and care of patients with myeloid neoplasms and marrow failure.

Boston, Massachusetts, USA
Vrijeme pridruživanja: kolovoz 2014.

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    David Steensma‏ @DavidSteensma 4. pro 2019.
    • Prijavi Tweet

    #HematologyTweetstory 10: how did the 5 major #nucleobases get their names? This is slightly tangential to hematology, admittedly, but is a cool story that I’ve been aching to tell since I went through an intense etymology phase many years ago (still have lots of dusty books)./1pic.twitter.com/F8C8RgIE7r

    15:36 - 4. pro 2019.
    • 551 proslijeđeni Tweet
    • 1.102 oznake „sviđa mi se”
    • Rugby girl Tom Numrych Daan Noordermeer lab Ruslan Medzhitov Jitu George Birgit Meldal sofia alondra lara Euron
    28 replies 551 proslijeđeni tweet 1.102 korisnika označavaju da im se sviđa
      1. Novi razgovor
      2. David Steensma‏ @DavidSteensma 4. pro 2019.
        • Prijavi Tweet

        #Guanine is probably the most interesting of the 5. It was first isolated in 1846 from guano, i.e. bird crap, by German chemist Julius Bodo Unger (1819-1885), who studied with the famous Justus Liebeg in Gießen. Unger later owned a factory in #Hannover. Guano image from JSTOR./2pic.twitter.com/8JpKFcUj9H

        17 proslijeđenih tweetova 93 korisnika označavaju da im se sviđa
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      3. David Steensma‏ @DavidSteensma 4. pro 2019.
        • Prijavi Tweet

        It is hard to imagine just how important seabird guano was economically, back before the beginning of the 20th century when Fritz Haber (who favored #PelgerHuet style eyeglasses😉) figured out how to fix nitrogen artificially & make ammonia. Guano was used for fuel, fertilizer./3pic.twitter.com/MEuSvJwvpp

        10 proslijeđenih tweetova 65 korisnika označava da im se sviđa
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      4. David Steensma‏ @DavidSteensma 4. pro 2019.
        • Prijavi Tweet

        There was even an “Age of Guano” (!) in the 19th century, when the colonial powers snatched up remote little islands around the world... for their guano. One of the reasons the US still claims a bunch of Pacific islands is because of that phase of acquisitiveness in the 1850s. /4pic.twitter.com/mfs8DC7rmc

        5 replies 18 proslijeđenih tweetova 59 korisnika označava da im se sviđa
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      5. David Steensma‏ @DavidSteensma 4. pro 2019.
        • Prijavi Tweet

        Guano was heavily advertised, too. Because when you see a lovely pastoral image with attractive farmers like this one, the first thing that comes to mind is seabird dung 💩, right? /5pic.twitter.com/wTZnit4rI8

        9 proslijeđenih tweetova 51 korisnik označava da mu se sviđa
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      6. David Steensma‏ @DavidSteensma 4. pro 2019.
        • Prijavi Tweet

        "Guano" is Spanish, but the original word "wanu" was Quechua - the Mayan tongue. It's rare for me to get through clinic or hospital rounds without needing at least one interpreter. (Picture = Brueghel’s Tower of Babel.) The hardest interpreter I ever had to come by: Quechua./6pic.twitter.com/XXkGJkoelV

        8 replies 9 proslijeđenih tweetova 53 korisnika označavaju da im se sviđa
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      7. David Steensma‏ @DavidSteensma 4. pro 2019.
        • Prijavi Tweet

        The next 3 nucleobases were all named by "Ludwig Karl Martin Leonhard Albrecht Kossel" (1853–1927), whose name is reminiscent of massive German compound words. His student Albert Neumann also did key experiments. In addition boasting a fine mustache, Kossel won 1910 Nobel Prize.pic.twitter.com/WmgY94xQST

        1 reply 7 proslijeđenih tweetova 46 korisnika označava da im se sviđa
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      8. David Steensma‏ @DavidSteensma 4. pro 2019.
        • Prijavi Tweet

        #Adenine was first isolated from the pancreas of an ox in 1885 (gland = adeno-, or ἀδήν- in Greek). Not clear why Kossel and Neumann were using the pancreas of an ox for their extractions, other than that it is really big (the same reason it was once used for making insulin.)/8pic.twitter.com/PRJzLiTY1x

        1 reply 13 proslijeđenih tweetova 68 korisnika označava da im se sviđa
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      9. David Steensma‏ @DavidSteensma 4. pro 2019.
        • Prijavi Tweet

        Then came #thymine, in 1893. Thymine was first extracted from calf thymus, hence the name. BTW the -ine suffix has 2 meanings: “derived from" and "containing nitrogen", both of which apply to the 3 nucleobases thus far./9pic.twitter.com/Le846Gjqma

        1 reply 10 proslijeđenih tweetova 60 korisnika označava da im se sviđa
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      10. David Steensma‏ @DavidSteensma 4. pro 2019.
        • Prijavi Tweet

        Weirdly, the thymus itself is named after thyme (Genus "Thymus"): that wonderful herb that is essential in Mediterranean cooking. Supposedly the name is because the thymus gland resembles thyme leaves. I have to say, this resemblance seems a bit of a stretch to me.../10pic.twitter.com/vwba07SqFp

        6 proslijeđenih tweetova 64 korisnika označavaju da im se sviđa
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      11. David Steensma‏ @DavidSteensma 4. pro 2019.
        • Prijavi Tweet

        Then came cytosine, also first isolated from thymus. Cyto=cell, of course. Low marks for creativity on cytosine! I mean, how many zillions of nitrogenous substances can we say are “derived from cells”? Kossel and Neumann were just mailing it in by this point… #LazyScientist/11pic.twitter.com/jTIAxvqMrd

        10 proslijeđenih tweetova 68 korisnika označava da im se sviđa
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      12. David Steensma‏ @DavidSteensma 4. pro 2019.
        • Prijavi Tweet

        I don't mean to diss cytosine itself, though, which is a particularly cool base because of all the different methylation-related variants including transient species. This image is from http://WhatIsEpigenetics.com  /12pic.twitter.com/w8JRGbptJI

        1 reply 8 proslijeđenih tweetova 47 korisnika označava da im se sviđa
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      13. David Steensma‏ @DavidSteensma 4. pro 2019.
        • Prijavi Tweet

        Last, RNA uracil - the only one that doesn’t end in -ine. In 1885, German chemist Robert Behrend (1856-1926) created a bunch of derivatives of “uric” acid (so called because it was first isolated from kidney stones in 1776 by #Scheele); one of them he called "uracil". /13pic.twitter.com/NhcmqYFWJG

        1 reply 9 proslijeđenih tweetova 48 korisnika označava da im se sviđa
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      14. David Steensma‏ @DavidSteensma 4. pro 2019.
        • Prijavi Tweet

        -il is an unusual suffix; it doesn't have the same specific meaning as a lot of other organic chem suffixes. I'm not sure why Behrend chose that. The journal he published his results in was named after Justus Liebeg – a connection with the guano story above./14pic.twitter.com/CeJAZKtsNH

        5 proslijeđenih tweetova 32 korisnika označavaju da im se sviđa
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      15. David Steensma‏ @DavidSteensma 4. pro 2019.
        • Prijavi Tweet

        So what prompted this tutorial? The proposal by @NHSuk Health Secretary @MattHancock to sequence all newborns in the UK. Perhaps that is the way of the future, but for now, it is reminscent of the 1997 Ethan Hawke/Jude Law/Uma Thurman dystopian sci-fi film GATTACA. /15pic.twitter.com/rcpnhRI6As

        5 replies 9 proslijeđenih tweetova 67 korisnika označava da im se sviđa
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      16. David Steensma‏ @DavidSteensma 4. pro 2019.
        • Prijavi Tweet

        This is the penultimate #HematologyTweetstory for 2019. I'm busy working on an @ASHClinicalNews essay about dystopian 2020 and am planning ~Dec. 25 "A Howell-Jolly Christmas" (w/ apologies to Burl Ives and his #HollyJollyChristmas 🎄🎶🎵 For those attending: enjoy #ASH19 !/16End

        6 replies 8 proslijeđenih tweetova 101 korisnik označava da mu se sviđa
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