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David Mayhew, MD, PhD proslijedio/la je Tweet
i’d say that it requires visionary leadership above to see the value of the research & invest, and patience to wait for it to pay off. research is slow. RVUs are fast. thx
@DrJohnSuh and@BrianBolwellMD at@ClevelandClinic for seeing that & sticking to their beliefs (& to us)Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
When not 1 but 2 major experiments in the same day work perfectly.pic.twitter.com/VDJ5WBX4Wv
Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
David Mayhew, MD, PhD proslijedio/la je TweetHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi
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David Mayhew, MD, PhD proslijedio/la je Tweet
I’m thrilled to announce the publication of the quantitive proteomic profiling of the Cancer Cell Line Encyclopedia. The
@GygiLab in collaboration with colleagues at Novartis and the Broad we measured the proteomes of 375 cell lines from various tumor lineages (1/13)pic.twitter.com/WXgsODMzFs
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This is what it’s all about. All of it.https://twitter.com/GinaHollenbeck/status/1220078455196471296 …
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David Mayhew, MD, PhD proslijedio/la je Tweet
Mutational signatures in tumours induced by high and low doses of
#ionisingradiation in p53 mutant (LOF) background. ROS signature found.https://www.nature.com/articles/s41467-019-14261-4 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
David Mayhew, MD, PhD proslijedio/la je Tweet
Exciting new evidence that the eIF4A protein is an RNA chaperone that blocks RNA condensation & limits stress granule formation in human cells
@CellCellPress@gabtaub@anthonykkhong@bvt_sciencegeek@BioFrontiers@CUBIOCHEM1#RNA#stressgranules https://www.cell.com/cell/fulltext/S0092-8674(19)31393-5 …pic.twitter.com/Br2QCEGct6
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David Mayhew, MD, PhD proslijedio/la je Tweet
Key pivots of hippo signaling- YAP/TAZ are understood to be functionally redundant. Our collab Moshe Oren+
@michal_shaked@WeizmannScience found otherwise. We systematically characterize the division of labor btw YAP & TAZ in lung cancer@Sanjusinha7 http://bit.ly/370N58h pic.twitter.com/dgs8TGKzK0
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David Mayhew, MD, PhD proslijedio/la je Tweet
This Is Our Cells Under Pressure: Decreased DNA Damage Repair in Response to Targeted Therapies Facilitates the Emergence of Drug-Resistant Clones http://dlvr.it/RN3LYp pic.twitter.com/iPhO8VcbFr
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David Mayhew, MD, PhD proslijedio/la je Tweet
This is a cool tool, congrats
@apatgir and@VamsiMootha! An engineered enzyme that targets circulating lactate to alleviate intracellular NADH:NAD+ imbalancehttps://www.nature.com/articles/s41587-019-0377-7 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Congrats to all the Rad Onc peeps at UAB!https://twitter.com/UABradonc/status/1216792701028335616 …
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David Mayhew, MD, PhD proslijedio/la je Tweet
New study finds that
#patient step counts may predict outcomes for people undergoing chemoradiation therapy for#LungCancer: http://ow.ly/JMYa50xQ9wJ#RadOnc#LCSM@MontefioreNYC@EinsteinMed@LUNGevity@LUNGFORCE#RedJournalpic.twitter.com/7g6pnr97aK
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Breast cancer: where a <1% difference in 10 yr IBTR still "did not meet the criteria for equivalence" between APBI and whole breast radiation.https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)32514-0/fulltext …
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David Mayhew, MD, PhD proslijedio/la je Tweet
For all but a few mRNAs, the dynamics of metabolism are unknown. A new study led by researchers in David Bartel’s lab provides a framework for examining mRNA metabolic dynamics from thousands of genes: https://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30896-2 …
@HHMINEWS@MITBiology@ScienceMIT@MolecularCellPrikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
David Mayhew, MD, PhD proslijedio/la je Tweet
Happy to finally share this work!! Proteasomes cluster at the ER, apparently by phase separation. We propose that these clustered proteasomes perform ERAD. They directly engage a specialized patch of the ER membrane and are surrounded by a cloud of Cdc48. https://www.pnas.org/content/early/2019/12/26/1905641117 …pic.twitter.com/hciXClfGRs
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David Mayhew, MD, PhD proslijedio/la je Tweet
Researchers at the
@sangerinstitute and@broadinstitute have validated the two largest#CRISPR-Cas9 genetic screens across 25 different cancer types. Once integrated, the datasets will bring us a step closer to the Cancer Dependency Map.http://bit.ly/2PLkaixHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
David Mayhew, MD, PhD proslijedio/la je Tweet
Published online today!! An AKT degrader/PROTAC! In cells it outperforms allosteric and catalytic AKT inhibitors. Thanks to the genius of Nathanael Gray
@DFCI_ChemBio and two brilliant graduate students Inchul You and Emily Erickson who share first prize!!https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(19)30396-4 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
David Mayhew, MD, PhD proslijedio/la je Tweet
Please RT: We are hiring for funded
#postdoc positions@UNC_Lineberger! We study#genome instability, synthetic lethality, and DNA damage/immunotherapy responses in#breastcancer using#CRISPR, genetic screens, next-gen mouse models, and genomic assays. DM and/or apply below.pic.twitter.com/XX5tfqv5Mt
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David Mayhew, MD, PhD proslijedio/la je Tweet
mTORC2 affects the maintenance of the skeletal muscle stem cell pool (satellite cells)
#myotwitter#skeletalmuscle@BioMedCentral…https://skeletalmusclejournal.biomedcentral.com/articles/10.1186/s13395-019-0217-y …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
David Mayhew, MD, PhD proslijedio/la je Tweet
Excited to share our preprint describing MIX-seq [https://www.biorxiv.org/content/10.1101/868752v1 …]! MIX-seq is an approach for multiplexed transcriptional profiling of chemical and genetic perturbations in large pools of co-treated cancer cell lines, with single-cell resolution. (1/5)pic.twitter.com/9PlUBNUaMC
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