David Mayhew, MD, PhD

@DavidLMayhew

Scientist, Rad Onc investigating mRNA translation and basic mechanisms of oncogenesis. Tweets = mine and not medical advice.

Dana-Farber Cancer Institute
Vrijeme pridruživanja: svibanj 2015.

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  1. proslijedio/la je Tweet
    26. sij
    Odgovor korisnicima i sljedećem broju korisnika:

    i’d say that it requires visionary leadership above to see the value of the research & invest, and patience to wait for it to pay off. research is slow. RVUs are fast. thx and at for seeing that & sticking to their beliefs (& to us)

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  2. 25. sij

    When not 1 but 2 major experiments in the same day work perfectly.

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  3. proslijedio/la je Tweet
    23. sij

    Yep! I'm putting it out there 🤭

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  4. proslijedio/la je Tweet
    23. sij

    I’m thrilled to announce the publication of the quantitive proteomic profiling of the Cancer Cell Line Encyclopedia. The in collaboration with colleagues at Novartis and the Broad we measured the proteomes of 375 cell lines from various tumor lineages (1/13)

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  5. 23. sij
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  6. proslijedio/la je Tweet
    21. sij

    Mutational signatures in tumours induced by high and low doses of in p53 mutant (LOF) background. ROS signature found.

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  7. proslijedio/la je Tweet
    15. sij

    Exciting new evidence that the eIF4A protein is an RNA chaperone that blocks RNA condensation & limits stress granule formation in human cells

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  8. proslijedio/la je Tweet

    Key pivots of hippo signaling- YAP/TAZ are understood to be functionally redundant. Our collab Moshe Oren+ found otherwise. We systematically characterize the division of labor btw YAP & TAZ in lung cancer

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  9. proslijedio/la je Tweet
    15. sij

    This Is Our Cells Under Pressure: Decreased DNA Damage Repair in Response to Targeted Therapies Facilitates the Emergence of Drug-Resistant Clones

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  10. proslijedio/la je Tweet
    13. sij

    This is a cool tool, congrats and ! An engineered enzyme that targets circulating lactate to alleviate intracellular NADH:NAD+ imbalance

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  11. 13. sij

    Congrats to all the Rad Onc peeps at UAB!

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  12. proslijedio/la je Tweet
    8. sij

    New study finds that step counts may predict outcomes for people undergoing chemoradiation therapy for :

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  13. 8. sij

    Breast cancer: where a <1% difference in 10 yr IBTR still "did not meet the criteria for equivalence" between APBI and whole breast radiation.

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  14. proslijedio/la je Tweet

    For all but a few mRNAs, the dynamics of metabolism are unknown. A new study led by researchers in David Bartel’s lab provides a framework for examining mRNA metabolic dynamics from thousands of genes:

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  15. proslijedio/la je Tweet
    27. pro 2019.

    Happy to finally share this work!! Proteasomes cluster at the ER, apparently by phase separation. We propose that these clustered proteasomes perform ERAD. They directly engage a specialized patch of the ER membrane and are surrounded by a cloud of Cdc48.

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  16. proslijedio/la je Tweet
    20. pro 2019.

    Researchers at the and have validated the two largest -Cas9 genetic screens across 25 different cancer types. Once integrated, the datasets will bring us a step closer to the Cancer Dependency Map.

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  17. proslijedio/la je Tweet
    16. pro 2019.

    Published online today!! An AKT degrader/PROTAC! In cells it outperforms allosteric and catalytic AKT inhibitors. Thanks to the genius of Nathanael Gray and two brilliant graduate students Inchul You and Emily Erickson who share first prize!!

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  18. proslijedio/la je Tweet
    11. pro 2019.

    Please RT: We are hiring for funded positions ! We study instability, synthetic lethality, and DNA damage/immunotherapy responses in using , genetic screens, next-gen mouse models, and genomic assays. DM and/or apply below.

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  19. proslijedio/la je Tweet
    10. pro 2019.

    mTORC2 affects the maintenance of the skeletal muscle stem cell pool (satellite cells)

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  20. proslijedio/la je Tweet
    9. pro 2019.

    Excited to share our preprint describing MIX-seq []! MIX-seq is an approach for multiplexed transcriptional profiling of chemical and genetic perturbations in large pools of co-treated cancer cell lines, with single-cell resolution. (1/5)

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