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DavidBeniaguev's profile
David Beniaguev
David Beniaguev
David Beniaguev
@DavidBeniaguev

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David Beniaguev

@DavidBeniaguev

Computational Neuroscience PhD Student. Trying to understand the Brain with the hope to help build AI someday. For fun, I build ML Generative Models.

Israel
kaggle.com/selfishgene
Joined June 2017

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    1. David Beniaguev‏ @DavidBeniaguev 24 May 2019

      6) So it turns out that most of the processing complexity of a single neuron is the result of two specific biological mechanisms - the distributed nature of the dendritic tree coupled with the NMDA ion channel. Take away one of those things - and a neuron turns to a simple device

      2 replies 16 retweets 95 likes
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    2. David Beniaguev‏ @DavidBeniaguev 24 May 2019

      7) One additional advantage deep neural netowrks have compared to thousands of complicated differential equations, is the ability to visualize their inner workings. The simplest method is to look at the first layer weights of the neural network:

      1 reply 2 retweets 46 likes
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    3. David Beniaguev‏ @DavidBeniaguev 24 May 2019

      8) Here depicted are weights for one of the artificial units in first layer of the large DNN that mimics a neuron with the full complexity: One can see the spatio-temporal structure of synaptic integration: The basal and oblique trees integrate predominantly recent inputspic.twitter.com/93JOjgd4yr

      1 reply 9 retweets 50 likes
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    4. David Beniaguev‏ @DavidBeniaguev 24 May 2019

      9) Here, a different first layer unit, the apical tree appears to pay attention to what happened on it for many more milliseconds than the basal and oblique trees that we saw in previous unit (BTW, the blue traces are inhibition, the red traces are excitation)pic.twitter.com/O5oAr8vxkK

      2 replies 4 retweets 38 likes
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    5. David Beniaguev‏ @DavidBeniaguev 24 May 2019

      10) if we look at the first layer units of the small DNN that fitted the neuron with AMPA only synapses, then it appears that the units don't really pay attention at all to what happens at the apical tree or any distal locations at basal and oblique trees.pic.twitter.com/QEBDzsB2KY

      1 reply 3 retweets 32 likes
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    6. David Beniaguev‏ @DavidBeniaguev 24 May 2019

      11) it is a little bit hard to see the details of what's going on in those weight plots because there are so many synapses. So Let's focus on a single dendritic branch and zoom in on it. For a single branch with NMDA, it's possible to mimic it's behavior with only 4 hidden unitspic.twitter.com/W1RKKURaUu

      1 reply 3 retweets 35 likes
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    7. David Beniaguev‏ @DavidBeniaguev 24 May 2019

      12) and here are it's spatio-temporal patterns of integration: I'll verbally describe those filters from top to bottom as questions that the neuron is "asking" the input in order to determine its output (Note: no inhibition here, only excitation. time window extent is 100ms)pic.twitter.com/J6Qqdy01fu

      1 reply 2 retweets 31 likes
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    8. David Beniaguev‏ @DavidBeniaguev 24 May 2019

      13) unit 1: was there very recent excitation that was proximal to soma? unit 2: was there very recent excitation that was distal to soma? unit 3: was there a quick distal to proximal pattern of excitation? unit 4: was there a slow distal to proximal pattern of excitation?pic.twitter.com/jE9uarrJkD

      1 reply 6 retweets 34 likes
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    9. David Beniaguev‏ @DavidBeniaguev 24 May 2019

      14) many more details are in the preprint on bioRxiv: https://www.biorxiv.org/content/10.1101/613141v1 … @bioRxiv @biorxiv_neursci

      4 replies 9 retweets 62 likes
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    10. David Beniaguev‏ @DavidBeniaguev 24 May 2019

      15) huge thanks to my PhD supervisors @Segev_Lab and @mikilon and also to all my lab mates @TMoldwin @Oren_Amsalem @GuyEyal @MichaelDoronII @gialdetti and also to everyone else that listened to me talked on and on of these stuff in the past! :-)

      16 replies 4 retweets 59 likes
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      David Beniaguev‏ @DavidBeniaguev Apr 1

      David Beniaguev Retweeted David Beniaguev

      Released all code and data of this work! Think you can build a simpler yet not less accurate model for a single neuron? Just want to analyze the input-output dataset from a completely new perspective? I've tried making all of that as simple as I couldhttps://twitter.com/DavidBeniaguev/status/1244334898888007693 …

      David Beniaguev added,

      David Beniaguev @DavidBeniaguev
      Code, data and pre-trained networks released for our work "Single Cortical Neurons as Deep Artificial Neural Networks" #tweeprint updated preprint: https://www.biorxiv.org/content/10.1101/613141v2 … replicating main result on @kaggle: https://www.kaggle.com/selfishgene/single-neuron-as-deep-net-replicating-key-result … github repo: https://github.com/SelfishGene/neuron_as_deep_net … (1/n) pic.twitter.com/0Vraiv1Rcr
      Show this thread
      4:16 AM - 1 Apr 2020
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      • Peter Finnie André Marques-Smith Olivier Marre
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