People’s reaction to aspirin is determined by pharmacogenomics
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Replying to @DanteLabs
Okay, I'll bite. Here's what's under the "learn more" button: "Individuals with the AC genotype who are treated with aspirin may have an increased risk of urticaria as compared to patients with the AA genotype."pic.twitter.com/05qnbJE8aC
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Replying to @fdmts @DanteLabs
First off, let's check out what "urticaria" is. It's hives, red bumps on the skin. Sometimes itchy. Very common, lots of causes, including foods, medicines, and stress.pic.twitter.com/8bKoxXUxLZ
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Replying to @fdmts @DanteLabs
As a sanity check, I verified that
@23andMe agrees with that 'AC' call at rs720012. We're in good shape on that. > grep rs730012 genome_Christopher_Dwan_v1_v2_v3_Full_20170926071925.txt > rs730012 . 5 . 179220638 . AC1 reply 0 retweets 0 likes -
Clinvar (https://www.ncbi.nlm.nih.gov/clinvar/variation/226018/ …) agrees with the idea that there's an association there. References going back to 2004.pic.twitter.com/gNMO3A9nxZ
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Unfortunately, the three studies listed are not super powerful. The biggest of them (https://www.ncbi.nlm.nih.gov/pubmed/19862937 ) studied 275 people and found "The C allele was more frequent in patients with the cutaneous pattern of AIU and in patients with low skin reactivity to histamine"
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Replying to @fdmts @DanteLabs
So one question is "how rare is this variant?" Turns out that it's super common for white folks to have at least one 'C' at this position. More than half of us do.pic.twitter.com/u2sbP1i6kN
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Replying to @fdmts @DanteLabs
I take a low dose aspirin every day. Should I stop? A quick look at
@SNPedia says "probably not." Rs6983267, over on chromosome 8 is a risk marker for colorectal cancer. I've got the GT variant which is the one where aspirin reduces risk.pic.twitter.com/r1F0t6ffIX
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Sadly, that didn't make the cut for
@DanteLabs. According to them I have no risk markers for any sort of cancer whatsoever.pic.twitter.com/W6j6Vgf16U
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Replying to @fdmts @DanteLabs
My point is that this stuff is both COMPLEX and SUPER IMPORTANT. Naively putting "high risk" next to aspirin based on a single SNP could guide me to stop using aspirin, increasing my risk of the cancer that killed my grandfather out of a desire to avoid itchy hives.
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Thanks for the feedback. We will change the language
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