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DanteLabs's profile
Dante Labs
Dante Labs
Dante Labs
@DanteLabs

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Dante Labs

@DanteLabs

Empowering people with the most advanced DNA test - the whole genome sequencing with personalized reports. Chat to us: @DanteLabs

Italy & United States
dantelabs.com
Joined April 2017

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    1. Dante Labs‏ @DanteLabs 15 Jul 2019
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      Replying to @fdmts

      People’s reaction to aspirin is determined by pharmacogenomics

      1 reply 0 retweets 0 likes
    2. Chris Dwan (he / him)‏ @fdmts 15 Jul 2019
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      Replying to @DanteLabs

      Okay, I'll bite. Here's what's under the "learn more" button: "Individuals with the AC genotype who are treated with aspirin may have an increased risk of urticaria as compared to patients with the AA genotype."pic.twitter.com/05qnbJE8aC

      1 reply 0 retweets 0 likes
    3. Chris Dwan (he / him)‏ @fdmts 15 Jul 2019
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      Replying to @fdmts @DanteLabs

      First off, let's check out what "urticaria" is. It's hives, red bumps on the skin. Sometimes itchy. Very common, lots of causes, including foods, medicines, and stress.pic.twitter.com/8bKoxXUxLZ

      1 reply 0 retweets 0 likes
    4. Chris Dwan (he / him)‏ @fdmts 15 Jul 2019
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      Replying to @fdmts @DanteLabs

      As a sanity check, I verified that @23andMe agrees with that 'AC' call at rs720012. We're in good shape on that. > grep rs730012 genome_Christopher_Dwan_v1_v2_v3_Full_20170926071925.txt > rs730012 . 5 . 179220638 . AC

      1 reply 0 retweets 0 likes
    5. Chris Dwan (he / him)‏ @fdmts 15 Jul 2019
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      Replying to @fdmts @DanteLabs @23andMe

      Clinvar (https://www.ncbi.nlm.nih.gov/clinvar/variation/226018/ …) agrees with the idea that there's an association there. References going back to 2004.pic.twitter.com/gNMO3A9nxZ

      1 reply 0 retweets 0 likes
    6. Chris Dwan (he / him)‏ @fdmts 15 Jul 2019
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      Replying to @fdmts @DanteLabs @23andMe

      Unfortunately, the three studies listed are not super powerful. The biggest of them (https://www.ncbi.nlm.nih.gov/pubmed/19862937 ) studied 275 people and found "The C allele was more frequent in patients with the cutaneous pattern of AIU and in patients with low skin reactivity to histamine"

      1 reply 0 retweets 0 likes
    7. Chris Dwan (he / him)‏ @fdmts 15 Jul 2019
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      Replying to @fdmts @DanteLabs

      So one question is "how rare is this variant?" Turns out that it's super common for white folks to have at least one 'C' at this position. More than half of us do.pic.twitter.com/u2sbP1i6kN

      1 reply 0 retweets 1 like
    8. Chris Dwan (he / him)‏ @fdmts 15 Jul 2019
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      Replying to @fdmts @DanteLabs

      I take a low dose aspirin every day. Should I stop? A quick look at @SNPedia says "probably not." Rs6983267, over on chromosome 8 is a risk marker for colorectal cancer. I've got the GT variant which is the one where aspirin reduces risk.pic.twitter.com/r1F0t6ffIX

      1 reply 0 retweets 1 like
    9. Chris Dwan (he / him)‏ @fdmts 15 Jul 2019
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      Replying to @fdmts @DanteLabs @SNPedia

      Sadly, that didn't make the cut for @DanteLabs. According to them I have no risk markers for any sort of cancer whatsoever.pic.twitter.com/W6j6Vgf16U

      1 reply 0 retweets 0 likes
    10. Chris Dwan (he / him)‏ @fdmts 15 Jul 2019
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      Replying to @fdmts @DanteLabs

      My point is that this stuff is both COMPLEX and SUPER IMPORTANT. Naively putting "high risk" next to aspirin based on a single SNP could guide me to stop using aspirin, increasing my risk of the cancer that killed my grandfather out of a desire to avoid itchy hives.

      2 replies 0 retweets 1 like
      Dante Labs‏ @DanteLabs 15 Jul 2019
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      Replying to @fdmts

      Thanks for the feedback. We will change the language

      2:02 PM - 15 Jul 2019
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      • Chris Dwan (he / him)
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