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DanielleFong's profile
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@DanielleFong

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@DanielleFong

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Empire of the Future
Joined February 2008

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    1. Andy Slavitt  🇺🇸 💉‏Verified account @ASlavitt 7 Sep 2021

      Problematic variants that can’t grow as fast as Delta will be only a limited problem. When we read about a Mu (0.1%) being a problem for vaccines, if it can’t outcompete Delta, it won’t take hold. 8/

      10 replies 159 retweets 1,270 likes
      Show this thread
    2. Andy Slavitt  🇺🇸 💉‏Verified account @ASlavitt 7 Sep 2021

      So Delta, oddly, is defeating variants that would be more challenging for vaccines (and also monoclonals). And until a variant that causes problems for the vaccine also spreads faster than Delta, it won’t become dominant. 9/

      20 replies 269 retweets 1,740 likes
      Show this thread
    3. Andy Slavitt  🇺🇸 💉‏Verified account @ASlavitt 7 Sep 2021

      As an aside, Delta causes some problems for the vaccine but in a different way— because it replicates more virus so quickly that w/ lower antibody levels, immune response often isn’t fast enough to prevent symptoms. Cellular immunity does kick if to prevent hospitalizations. 10/

      4 replies 172 retweets 1,312 likes
      Show this thread
    4. Andy Slavitt  🇺🇸 💉‏Verified account @ASlavitt 7 Sep 2021

      So why hasn’t a variant come along that has both negative characteristics? Will it? The answer to the first question is largely randomness. There’s no reason why both types of mutations can’t exist in the same virus variant. 11/

      3 replies 109 retweets 1,020 likes
      Show this thread
    5. Andy Slavitt  🇺🇸 💉‏Verified account @ASlavitt 7 Sep 2021

      The more opportunity, the more random things will happen. So it’s also the length of time of the pandemic, the spread & the too slow, too low vaccination rates that increases the odds. 12/

      3 replies 163 retweets 1,178 likes
      Show this thread
    6. Andy Slavitt  🇺🇸 💉‏Verified account @ASlavitt 7 Sep 2021

      Will it happen? We don’t know but we do know that vaccinating the globe and the US more quickly will reduce the odds. In the scheme of viruses Delta already replicates very fast. Not close to measles, but arguably comparable to chicken pox. That’s a tall order for a mutant. 13/

      7 replies 149 retweets 1,318 likes
      Show this thread
    7. Andy Slavitt  🇺🇸 💉‏Verified account @ASlavitt 7 Sep 2021

      So we could expect to see a lot of “problematic” mutations for the vaccines that never amount to much because Delta crushes them. But what happens if we do see one that’s vaccine evasive that Delta doesn’t outcompete— or at least leaves room for it in some regions? 14/

      19 replies 88 retweets 993 likes
      Show this thread
    8. Andy Slavitt  🇺🇸 💉‏Verified account @ASlavitt 7 Sep 2021

      There are a few key ingredients that must be ready: surveillance, vaccine development, regulatory & scaled manufacturing/distribution. 15/

      4 replies 76 retweets 774 likes
      Show this thread
    9. Andy Slavitt  🇺🇸 💉‏Verified account @ASlavitt 7 Sep 2021

      We’ve taken a big step forward in surveillance with the CDC’s new forecasting center. Genetic sequencing need to occur however in many more regions of the US than it does now. Countries around the world are also improving their ability to spot variants quickly. 16/

      4 replies 91 retweets 821 likes
      Show this thread
    10. Andy Slavitt  🇺🇸 💉‏Verified account @ASlavitt 7 Sep 2021

      Once we identify a new variant, we can test its effectiveness against vaccines in the lab. If one is an evasive mutation, within 100 days we should have the capability to develop a new specialized booster. By that time we should know if the variant is outcompeting Delta. 17/

      12 replies 128 retweets 957 likes
      Show this thread
       🤷🏻‍♀️‏ @DanielleFong 7 Sep 2021
      Replying to @ASlavitt @UROCKlive1

      why haven’t we gotten a booster through that even encodes the long dominant d614g mutation? something is broken in the chain here, i fear

      8:34 PM - 7 Sep 2021
      0 replies 0 retweets 0 likes

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