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DanielleFong's profile
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@DanielleFong

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@DanielleFong

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Empire of the Future
Joined February 2008

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    1. Dr. Angela Rasmussen‏Verified account @angie_rasmussen 15 Jul 2021

      We hear often about how delta is more transmissible, but we don't hear much about why that's the case or how that impacts exposure risk. A new study by Li and colleagues is out on Virological that provides some insight:https://virological.org/t/viral-infection-and-transmission-in-a-large-well-traced-outbreak-caused-by-the-delta-sars-cov-2-variant/724 …

      108 replies 2,657 retweets 5,112 likes
      Show this thread
    2. Dr. Angela Rasmussen‏Verified account @angie_rasmussen 15 Jul 2021

      There's been a lot of breathless news coverage about delta and it's mostly focused on increased transmissibility (and maybe pathogenicity). VOCs aren't just inherently more transmissible (or more pathogenic). There must be a mechanism that underlies increased transmission.

      4 replies 96 retweets 588 likes
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    3. Dr. Angela Rasmussen‏Verified account @angie_rasmussen 15 Jul 2021

      Some hypothetical mechanisms include: -Increased fitness (more shedding) -Increased infectivity (better at infecting host cells ie tighter receptor binding) -Longer period of contagion (shed virus for longer) -Increased environmental stability (more tolerant to temp/humidity/etc)

      4 replies 97 retweets 609 likes
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    4. Dr. Angela Rasmussen‏Verified account @angie_rasmussen 15 Jul 2021

      This study attempted to address this in quarantined close contacts of confirmed cases. These people were tested daily by PCR, which allowed the investigators to determine the course of infection: longitudinal viral loads and time from exposure to positivity and symptoms.

      2 replies 67 retweets 471 likes
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    5. Dr. Angela Rasmussen‏Verified account @angie_rasmussen 15 Jul 2021

      The findings are quite striking. This shows that: -People infected with delta test positive more quickly following exposure, suggesting more rapid viral growth. -The viral loads (by PCR Ct) are 1000 times higher in delta when first detected.pic.twitter.com/ROZZzWwqhB

      32 replies 858 retweets 1,636 likes
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    6. Dr. Angela Rasmussen‏Verified account @angie_rasmussen 15 Jul 2021

      This suggests that the delta incubation period is reduced compared to the prior viruses. Also, people infected with delta are shedding a shit-ton more virus than those from earlier variants. This certainly explains delta's increased transmissibility.

      26 replies 564 retweets 1,565 likes
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    7. Dr. Angela Rasmussen‏Verified account @angie_rasmussen 15 Jul 2021

      If people are shedding 1000X more virus, the probability that a close contact will be exposed to an infectious dose is much higher. If people become contagious more quickly after exposure, they can have more opportunity to infect others.

      13 replies 342 retweets 1,146 likes
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    8. Dr. Angela Rasmussen‏Verified account @angie_rasmussen 15 Jul 2021

      Now, I've also seen a lot of 🚨DELTA IS MORE AIRBORNE!!!!!1!!!🚨 commentary, which is neither helpful nor accurate. A virus is a physical structure that still has to obey the laws of physics. It can't become "more airborne"...and I'm not even sure what that means.

      33 replies 184 retweets 1,191 likes
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       🤷🏻‍♀️‏ @DanielleFong 15 Jul 2021
      Replying to @angie_rasmussen

      atmospheric dwell time is nonlinear in particle size, so if delta biases to smaller virions it could have the effect of an increased viral load in the air, for longer. images i’ve seen indicate a significant dispersion in virion sizepic.twitter.com/xuj7g8xqDn

      8:59 AM - 15 Jul 2021
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      • Catherine Mancini Janet E. Kester Rafael Prince
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