theoretically, how long would it actually take to switch over the genetic code in the mRNA vaccines to (say) the delta variant in the pfizer supply chain. One might argue you need to do trials all over again — but maybe not. the manufacturing might be quite reprogrammable
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Replying to @DRO_oDR
are we doing this? we should have already subbed in at least the D614G mutation since it’s totally taken over
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Replying to @DanielleFong
Yeah, trials going on. Moderna is afaik slightly ahead. Not sure exactly which mutations they address but afaik polyvalent(?) including E484K etc.
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Replying to @DRO_oDR @DanielleFong
I'm not 100% into that news cycle, trying to learn how to relax about it. Regulation afaik requires Phase 1/2 at least but then may just give emergency auth if no issues.
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Replying to @DRO_oDR @DanielleFong
This is only for one mutation but pretty sure I saw more stuff going by. It's like you say, not that big of a deal to adjust the vaccine.https://clinicaltrials.gov/ct2/show/NCT04785144 …
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Replying to @DanielleFong
To be more exact, 2 months is the current time to produce vaccine start to delivery. Reprogramming can be done in little time but obviously requires certain tests so the timeframe widens. But none of this gets in the way, the production capacity is the bottleneck.
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well the good news is that 2 months is shorter than the rate there new variants are coming through for now, and there’s lots of crossover.
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