“wonder if down the line e.g. mRNA can be used to tell the immune system ‘hey attack this cancer’”
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Read about Carl June’s work dating back to 1980s and 1990s where the discovery of the CD28 costimulatory domain allowed us to begin to understand how to activate T cells and then combine with initially lentiviruses (HIV w/o HIV insert) inserting chimeric antigen receptors
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The CAR constructs are essentially an antibody fragment tethered to a signaling domain and nowadays we are dealing with fourth generation CAR-T and hundreds of clinical studies globally, most on liquid tumors but also increasingly on solid ones
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