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DanielleFong's profile
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@DanielleFong

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Empire of the Future
Joined February 2008

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    1. Eric Topol‏Verified account @EricTopol 20 Mar 2021

      Eric Topol Retweeted Kelly O'Donnell

      The P.1 variant has been found in many (>12) states. It is not as concerning as B.1.1.7 (UK) since it is nowhere near as infectious or associated with higher lethality. It has responded very well to the J&J vaccine and all data supports a full response to the mRNA vaccines, too.https://twitter.com/KellyO/status/1373368304761458689 …

      Eric Topol added,

      Kelly O'DonnellVerified account @KellyO
      New York announces the detection of its first case of the so-called Brazilian variant of covid. The patient is a Brooklyn resident with no travel history.
      60 replies 219 retweets 841 likes
      Show this thread
    2. Eric Feigl-Ding‏Verified account @DrEricDing 21 Mar 2021
      Replying to @EricTopol

      Hard disagree. You’ve clearly not been following P1. Stop dismissing P1.

      13 replies 22 retweets 218 likes
    3. Eric Topol‏Verified account @EricTopol 21 Mar 2021
      Replying to @DrEricDing

      I'm not dismissing it at all, have followed it closely. It has remarkable homology to B.1.351, less immune evasion; the data are mixed regarding its enhanced transmissibility ranging from 1.0 to 2.5X. B.1.351 has responded well to both J&J and Novavax vaccines. No alarmism needed

      17 replies 9 retweets 111 likes
    4. Monica de Bolle, PhD‏Verified account @bollemdb 21 Mar 2021
      Replying to @EricTopol @DrEricDing

      Sounding the alarm is actually warranted. P.1 is fast spreading in South America -- it is probably responsible for the lockdown in Santiago, Chile. It is also hammering Uruguay. Two countries that have been vaccinating at a good clip and had the epidemic under control...

      2 replies 5 retweets 33 likes
    5. Eric Topol‏Verified account @EricTopol 21 Mar 2021
      Replying to @bollemdb @DrEricDing

      Eric Topol Retweeted Eric Topol

      I posted on that earlier today https://twitter.com/EricTopol/status/1373658680713912326 … And since you reinforced how similar P.1 is to B.351 (which I fully agree) how do you explain the difference in what is being observed in South Africa vs South America?

      Eric Topol added,

      Eric TopolVerified account @EricTopol
      V3: Vaccination, Variants of Virus in the 3 countries where the major ones were identified UK: B.1.1.7, contained w/ lockdown and vaccination SA: B.1.351, contained w/ lockdown, no vaccination Brazil: P1, not contained, little vaccination B.1.351 & P.1 mutations are quite similar pic.twitter.com/ueWU1Nw7oL
      1 reply 5 retweets 14 likes
    6. Monica de Bolle, PhD‏Verified account @bollemdb 21 Mar 2021
      Replying to @EricTopol @DrEricDing

      That is a good question. The 2 VOCs have similar RBD mutations, but different NTD mutations. We definitely need to understand why they may behave differently.

      1 reply 2 retweets 12 likes
    7. Eric Topol‏Verified account @EricTopol 21 Mar 2021
      Replying to @bollemdb @DrEricDing

      Agree. The P.1. NTD mutations would be invoked for potential heightened immune evasion, but that hasn't been found to be the case compared with B.1.351 (which has so far been consistently shown to have more escape potential)

      2 replies 4 retweets 30 likes
    8. Eric Feigl-Ding‏Verified account @DrEricDing 21 Mar 2021
      Replying to @EricTopol @bollemdb

      P1 may respond to vaccines a little better than B1351. But it’s not that great. I’m more worried about the faster transmission. several newer studies suggests it’s 1.6-2.5x. And hospitalization based models often better in developing world where testing is not as frequent.

      4 replies 14 retweets 59 likes
       🤷🏻‍♀️‏ @DanielleFong 21 Mar 2021
      Replying to @DrEricDing @EricTopol @bollemdb

      what about recombination? is there any way to estimate the probability? i have been told ‘for RNA viruses some recombination events are inevitable’

      1:41 PM - 21 Mar 2021
      • 1 Like
      • Pravduh
      0 replies 0 retweets 1 like

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