The P.1 variant has been found in many (>12) states. It is not as concerning as B.1.1.7 (UK) since it is nowhere near as infectious or associated with higher lethality. It has responded very well to the J&J vaccine and all data supports a full response to the mRNA vaccines, too.https://twitter.com/KellyO/status/1373368304761458689 …
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Replying to @EricTopol
Hard disagree. You’ve clearly not been following P1. Stop dismissing P1.
13 replies 22 retweets 218 likes -
Replying to @DrEricDing
I'm not dismissing it at all, have followed it closely. It has remarkable homology to B.1.351, less immune evasion; the data are mixed regarding its enhanced transmissibility ranging from 1.0 to 2.5X. B.1.351 has responded well to both J&J and Novavax vaccines. No alarmism needed
17 replies 9 retweets 111 likes -
Replying to @EricTopol @DrEricDing
Sounding the alarm is actually warranted. P.1 is fast spreading in South America -- it is probably responsible for the lockdown in Santiago, Chile. It is also hammering Uruguay. Two countries that have been vaccinating at a good clip and had the epidemic under control...
2 replies 5 retweets 33 likes -
Replying to @bollemdb @DrEricDing
Eric Topol Retweeted Eric Topol
I posted on that earlier today https://twitter.com/EricTopol/status/1373658680713912326 … And since you reinforced how similar P.1 is to B.351 (which I fully agree) how do you explain the difference in what is being observed in South Africa vs South America?
Eric Topol added,
Eric TopolVerified account @EricTopolV3: Vaccination, Variants of Virus in the 3 countries where the major ones were identified UK: B.1.1.7, contained w/ lockdown and vaccination SA: B.1.351, contained w/ lockdown, no vaccination Brazil: P1, not contained, little vaccination B.1.351 & P.1 mutations are quite similar pic.twitter.com/ueWU1Nw7oL1 reply 5 retweets 14 likes -
Replying to @EricTopol @DrEricDing
That is a good question. The 2 VOCs have similar RBD mutations, but different NTD mutations. We definitely need to understand why they may behave differently.
1 reply 2 retweets 12 likes -
Replying to @bollemdb @DrEricDing
Agree. The P.1. NTD mutations would be invoked for potential heightened immune evasion, but that hasn't been found to be the case compared with B.1.351 (which has so far been consistently shown to have more escape potential)
2 replies 4 retweets 30 likes -
Replying to @EricTopol @bollemdb
P1 may respond to vaccines a little better than B1351. But it’s not that great. I’m more worried about the faster transmission. several newer studies suggests it’s 1.6-2.5x. And hospitalization based models often better in developing world where testing is not as frequent.
4 replies 14 retweets 59 likes
what about recombination? is there any way to estimate the probability? i have been told ‘for RNA viruses some recombination events are inevitable’
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