Still early to say for certain with respect to the #SARSCoV2 N501Y mutant’s effect on neutralizing antibody responses, reinfection, and vaccine efficacy. This mutant causes enhanced ACE2 receptor binding, though is unlikely to significantly affect antibody binding by itself.https://twitter.com/TheMenacheryLab/status/1341460343168577538 …
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This is not to say that the enhanced ACE2 binding couldn’t contribute to antibody escape and inefficacy of neutralizing antibodies against this virus in the presence of ACE2, which already competes with neutralizing antibodies with similar binding strength.
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Andre Watson 🧬 Retweeted Andre Watson 🧬
Andre Watson 🧬 added,
Andre Watson 🧬 @nanogenomicReplying to @TheMenacheryLabCan you repeat this experiment in the presence of increasing amounts of soluble ACE2 and/or ACE2-expressing cells e.g. ACE2-HEK293? This would be critical for studying whether the antibodies still carry out their effect in physiological environments when mutant binds >>> to ACE2.1 reply 0 retweets 1 likeShow this thread -
@Scobleizer@zacharylarson@eperlste@rtnarch @PRussW1@Plinz@DanielleFong@DStrachman@JimmyRis@elonmusk1 reply 0 retweets 0 likesShow this thread -
We can quickly tailor SARS-BLOCK to new mutants!
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Andre Watson 🧬 Retweeted Andre Watson 🧬
Andre Watson 🧬 added,
Andre Watson 🧬 @nanogenomicElated to share our preprint!!! Peptide Antidotes to SARS-CoV-2 (COVID19). In this study, we demonstrated that SARS-BLOCK™ peptides are potent inhibitors of infection in ACE2-expressing cells, and prevent ACE2 from binding to the viral spike protein. https://biorxiv.org/cgi/content/short/2020.08.06.238915v1 …Show this thread1 reply 0 retweets 4 likesShow this thread -
Andre Watson 🧬 Retweeted Florian Krammer
Some people are less concerned:https://twitter.com/florian_krammer/status/1341387794493693953 …
Andre Watson 🧬 added,
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I am concerned: people are ignoring the role of ACE2 in inhibiting antibody binding, which would be accentuated by increased ACE2 binding of this 501th spike protein amino acid mutant. https://www.nature.com/articles/s41423-020-0458-z.pdf … https://twitter.com/nanogenomic/status/1341640996686278662 …pic.twitter.com/r5zKdcpqFq
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hmm, you’re saying this could enhances the ace-2 camouflage you hypothesized. makes sense, hmm
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Replying to @nanogenomic @DanielleFong
If the virus spike proteins are all covered by free floating ACE2 then wouldn't the virus be no longer able to enter cells?
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