Memory improvements anyone? By the third month, it was clear that treated rats remembered the test maze much better than the untreated ones. 14/n
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The brain was an exception in terms of age-reversal, where the age reduction was significant using only some of the rat clocks (why is the brain so darn hard to fix? In this case, BBB barrier?) 15/n
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Level of oxidative stress, and (wait for it) senescent cells were reduced "by a very considerable degree". Presumably, the immune system cleared the senescent cells. This is what the field is looking for. 16/n
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The work shows, for the first time, that plasma fraction treatment reduces the epigenetic age of multiple tissues, and not by a little. What is in the plasma fraction that helps? Proteins, small chemicals, exosomes? 17/n
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This reminds me of Fleming and Florey, who found an extract of penicillium mold could treat infections. There will be a race to find all these factors. http://www.alkahest.com is already on the case. 18/n
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So are the result believable? I see nothing wrong with the epigenetic clock analyses, the stats - Horvath is the best there is. It's also hard to see how the other measures could be messed up. Controls Sure, I'd like to see more controls, quantification of images, etc. 19/n
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From what I can tell, the old control group didn't get injected with anything but saline. A better control would have been an injection of the old rats with old plasma fractions from rats of the same age, processed exactly the same way as the young plasma. 20/n
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Expect a rush to India to get this treatment. I do hope Nugenics conduct careful human clinical trials first. In the US, young plasma treatments were stopped by the FDA until further notice citing a lack of proven safety. 21/n
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If this finding holds up, rejuvenation of the body may become commonplace within our lifetimes, able to systemically reduce the risk of the onset of several diseases in the first place or provide resilence to a wide variety of infections. 22/n
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It will be interesting to see if reprogramming factors, such as OSK, are induced in the tissues of treated animals. This might explain the ability to reset age. Maybe it's a different set of genes for each organ. We will see....! 23/n end.
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