1/ Final piece of the puzzle! What SARS-Cov2 does to trigger Covid19 - after which secondary infections take over (severe patients have no viral load). This is probably the answer: CD147 & its role in extracellular matrix remodeling and degradationhttps://twitter.com/sanchak74/status/1247733355904303106 …
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Replying to @sanchak74
@nanogenomic this sounds similar to some of what we talked about1 reply 1 retweet 5 likes -
If what's being discussed isn't open source in the ways Sandeep has been engaging here and in other arenas in regards to SARSCoV2 inviting you to reconsider your approach, call on ALL labs working on this effort to join you in publishing ALL of your data on characterizing action.
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Even as our
#preprints have been consistently rejected by@biorxivpreprint and@Preprints_org without explanation or reason, we have consistently posted our approach and white papers to http://ligandal.com#ligandal@Ligandal1 reply 4 retweets 6 likes -
Replying to @nanogenomic @JodiKoberinski and
Been there...I pre-print in OSF now https://sanchakblog.wordpress.com/2019/11/01/crispr-chan-zuckerberg-biohub-biorxiv-how-big-money-controls-publication-in-the-crispr-led-gene-editing-hype/ … It doesnt take guts to speak the truth in science, it takes integrity. They lack that - yet, they have managed to grap the general public's admiration as open science proponents.
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Replying to @sanchak74 @nanogenomic and
*grab* And you probably know this, but if you are looking for an epitope, this is a good one - where an neutralizing antibody binds (around K378). It has a PDB structure..https://sanchakblog.wordpress.com/2020/03/07/the-rgd-motif-in-the-sars-cov2-is-close-to-the-antibody-binding-part-in-the-sars-cov2-protein/ …
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Replying to @sanchak74 @nanogenomic and
Sharing this with colleagues ... I'm learning the science of this along with your hypothesizing, Sandeep, feeling in over my head, and also delighted to be forced to continue my biology training (as a sociologist by training). Wishing it was under less dire circumstances.
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Replying to @JodiKoberinski @sanchak74 and
Andre Watson 🧬 💊 💉 Retweeted Andre Watson 🧬 💊 💉
Bad antibody, more than likely. https://twitter.com/nanogenomic/status/1251969427890827264?s=21 …https://twitter.com/nanogenomic/status/1251969427890827264 …
Andre Watson 🧬 💊 💉 added,
Andre Watson 🧬 💊 💉 @nanogenomic@FrancisCollins@NIHDirector in your article, "Antibody Points to Possible Weak Spot on Novel Coronavirus," the CR3022 antibody is binding to a receptor binding domain region that's buried in the larger, whole spike... I don't think it's going to work. https://directorsblog.nih.gov/2020/04/14/antibody-points-to-possible-weak-spot-on-novel-coronavirus/?utm_source=share&utm_medium=ios_app … pic.twitter.com/16uJUAgpCRShow this thread1 reply 4 retweets 6 likes
mmmm, i see...
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