Even as our #preprints have been consistently rejected by @biorxivpreprint and @Preprints_org without explanation or reason, we have consistently posted our approach and white papers to http://ligandal.com #ligandal @Ligandal
-
-
Replying to @nanogenomic @JodiKoberinski and
Been there...I pre-print in OSF now https://sanchakblog.wordpress.com/2019/11/01/crispr-chan-zuckerberg-biohub-biorxiv-how-big-money-controls-publication-in-the-crispr-led-gene-editing-hype/ … It doesnt take guts to speak the truth in science, it takes integrity. They lack that - yet, they have managed to grap the general public's admiration as open science proponents.
2 replies 6 retweets 6 likes -
Replying to @sanchak74 @nanogenomic and
*grab* And you probably know this, but if you are looking for an epitope, this is a good one - where an neutralizing antibody binds (around K378). It has a PDB structure..https://sanchakblog.wordpress.com/2020/03/07/the-rgd-motif-in-the-sars-cov2-is-close-to-the-antibody-binding-part-in-the-sars-cov2-protein/ …
4 replies 4 retweets 3 likes -
Replying to @sanchak74 @JodiKoberinski and
Nope, that’s a buried residue. Don’t look at RBD for antibodies. Look at whole S1 spike.
2 replies 1 retweet 0 likes -
Replying to @nanogenomic @JodiKoberinski and
How will an antibody bind to a buried residue? It must be exposed...
2 replies 2 retweets 3 likes -
Replying to @sanchak74 @nanogenomic and
Is there an order of thinking in some circles that would have researchers miss this point you both raise (buried receptors are not reactive) ?
2 replies 1 retweet 3 likes -
Replying to @JodiKoberinski @nanogenomic and
1/2 Well, Andre knows much more about this than me - I had dabbled in this a bit a while back, he can correct me In the prefusion form these proteins (usually) dont have any epitopes - they r hidden. But when they find a receptor, and r about to fuse, some residues are exposed
3 replies 1 retweet 4 likes -
Replying to @sanchak74 @JodiKoberinski and
2/2 And antibodies bind to those (not all antibodies neutralize- the SARS-Cov2 one does) Analyzing the perturbation in pre- and post-fusion proteins can help identify those epitopes, a work I had done a few years back.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965698/ …
1 reply 2 retweets 5 likes -
Replying to @sanchak74 @JodiKoberinski and
Yep, only 1-2 neutralizing antibodies matter for SARS-CoV-2’s spike protein. That’s why our synthetic peptide “nanorobot” approach is so important. https://www.ligandal.com/uploads/5/7/9/1/57913087/ligandal_vaccine_antidotes_4.16.2020.pdf …https://www.biospace.com/article/ligandal-proposes-antidote-to-covid-19-using-robot-like-peptide-scaffolds/ …
2 replies 2 retweets 2 likes -
Replying to @nanogenomic @sanchak74 and
have unintended consequences of this application of nanotech been fully entertained? Curious what work is being done along with discovery work to understand what happens when tech applied in biological systems and not in isolation?
2 replies 0 retweets 2 likes
no consequences can ever be fully entertained! have the consequences of this tweet been fully entertained? no! we are in world war virus — it is about managing the risk, not eliminating it
Loading seems to be taking a while.
Twitter may be over capacity or experiencing a momentary hiccup. Try again or visit Twitter Status for more information.