1/ Final piece of the puzzle! What SARS-Cov2 does to trigger Covid19 - after which secondary infections take over (severe patients have no viral load). This is probably the answer: CD147 & its role in extracellular matrix remodeling and degradationhttps://twitter.com/sanchak74/status/1247733355904303106 …
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Replying to @sanchak74
@nanogenomic this sounds similar to some of what we talked about1 reply 1 retweet 5 likes -
If what's being discussed isn't open source in the ways Sandeep has been engaging here and in other arenas in regards to SARSCoV2 inviting you to reconsider your approach, call on ALL labs working on this effort to join you in publishing ALL of your data on characterizing action.
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Even as our
#preprints have been consistently rejected by@biorxivpreprint and@Preprints_org without explanation or reason, we have consistently posted our approach and white papers to http://ligandal.com#ligandal@Ligandal1 reply 4 retweets 6 likes -
Replying to @nanogenomic @JodiKoberinski and
Been there...I pre-print in OSF now https://sanchakblog.wordpress.com/2019/11/01/crispr-chan-zuckerberg-biohub-biorxiv-how-big-money-controls-publication-in-the-crispr-led-gene-editing-hype/ … It doesnt take guts to speak the truth in science, it takes integrity. They lack that - yet, they have managed to grap the general public's admiration as open science proponents.
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Replying to @sanchak74 @nanogenomic and
*grab* And you probably know this, but if you are looking for an epitope, this is a good one - where an neutralizing antibody binds (around K378). It has a PDB structure..https://sanchakblog.wordpress.com/2020/03/07/the-rgd-motif-in-the-sars-cov2-is-close-to-the-antibody-binding-part-in-the-sars-cov2-protein/ …
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Replying to @sanchak74 @JodiKoberinski and
Nope, that’s a buried residue. Don’t look at RBD for antibodies. Look at whole S1 spike.
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Replying to @nanogenomic @JodiKoberinski and
How will an antibody bind to a buried residue? It must be exposed...
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Replying to @sanchak74 @nanogenomic and
Is there an order of thinking in some circles that would have researchers miss this point you both raise (buried receptors are not reactive) ?
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conventional thinking has almost stopped progress in physics for nearly 70 years
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