1/ Why are children safe? "Fetal hemoglobin that binds oxygen more strongly than adult hemoglobin saves children (and sickle-cell patients where it persists longer) from heme-binding (O2 sequestering) proteins of anaerobic bacteria (Prevotella, et al)"https://osf.io/vzmf3/
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Replying to @sanchak74
that's one reason. i also wonder about immunological effects, and telomeres. anything interesting on this?
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Replying to @DanielleFong
Dont think so... Immunity can explain some resistance, esp in adults. But why would all children be completely indifferent to this? I think this explains it quite well...
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Replying to @sanchak74
not immunity, immunological. some of the cases involve a systemic effect (maybe gastro via ACT-2, maybe catalyzed by meat instead of respiratory infection, which then becomes systemic) which after a long incubation can flood the system with a cytokine storm. that's the hypothesis
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Replying to @DanielleFong
Hmmm, possible - but it would not explain many other things.
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Replying to @sanchak74
I think your hypothesis has promise -- can you elaborate any further on areas where this one I just put forward calls short?
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well -- and I need to check this from many more angles, buuut -- children have a ton of telomeres, and old people don't. I wonder if there's a connection.
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Replying to @DanielleFong @sanchak74
Yes, immune senescence a feature of biological ageing. T cell activity drops off a cliff after about 65yp
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