With #COVI19 found in intestinal tract; urine and feces in the largest study to date, would you expect similar binding in the gut, or liver?
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Replying to @overseasdem
#ACE2 is expressed most highly in the intestines and GI. It’s also a secreted protein which may suggest that it coats the virus and then interacts with other proteins involved in the renin-angiotensin-aldosterone cascade. Check out ACE2 tissue expression https://www.proteinatlas.org/ENSG00000130234-ACE2/tissue …5 replies 12 retweets 29 likes -
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Gotta look at expression profiles of all systems/tissues/organs where ACE2-associated proteins express in
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Replying to @pychiatrist1972 @overseasdem
I don’t think it’s as much ACE2 as ACE2 co-complexes, at least that is my intuition based on the expression profile. And maybe lung enrichment in the endothelial cells etc but doesn’t seem to be the case based on the RNA-Seq data I’ve seen so far
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My hypothesis would be that ACE2 coats the virus and then leads to an “ACE2 stealth protein corona” on the viral surface
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i’m playing around with this idea in my head, it’s interesting. the “socket” on the virus doesn’t seem to be complete. so I can imagine that if there were a lot of dead epithelial cells from say, smoking in the lungs, the virus could sort of half pick up ACE-2 protein fragments.
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If you download PyMOL I can send you the files and you can drag it around in 3D and see where the amino acids are.
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do you have a time saving link for the best “get up to speed” on PyMOL?
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Let’s take this offline and do a screenshare sometime :))
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Excellent, let’s tonight or tomorrow
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End of conversation
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