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DanielleFong's profile
𝓓𝑎𝑛𝑖𝑒𝑙𝑙𝑒 𝓕𝑜𝑛𝑔, 𝕖𝕩-𝕡𝕣𝕠𝕕𝕚𝕘𝕪
𝓓𝑎𝑛𝑖𝑒𝑙𝑙𝑒 𝓕𝑜𝑛𝑔, 𝕖𝕩-𝕡𝕣𝕠𝕕𝕚𝕘𝕪
𝓓𝑎𝑛𝑖𝑒𝑙𝑙𝑒 𝓕𝑜𝑛𝑔, 𝕖𝕩-𝕡𝕣𝕠𝕕𝕚𝕘𝕪
@DanielleFong

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𝓓𝑎𝑛𝑖𝑒𝑙𝑙𝑒 𝓕𝑜𝑛𝑔, 𝕖𝕩-𝕡𝕣𝕠𝕕𝕚𝕘𝕪

@DanielleFong

𝔞 𝔟𝔩𝔞𝕤𝔱 𝔣𝔯𝔬𝔪 𝔱𝕙𝖊 𝔭𝔞𝔰𝔱 𝕝𝕖𝕧𝕖𝕝 𝟛𝟚 𝕤𝕠𝕣𝕔𝕖𝕣𝕖𝕤𝕤, 𝕙𝕒𝕣𝕕𝕔𝕠𝕣𝕖 𝕞𝕠𝕕𝕖

.earth  🌎
daniellefong.com
Joined February 2008

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    1. Andre Watson  🧬 💊 💉‏ @nanogenomic Feb 11
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      I ran thermodynamic simulations and sequence alignment to model the binding pocket and critical residues of nCoV2019 binding to the ACE2 receptor. The first picture is a crystal structure of SARS bound to ACE2, the second is a simulation of nCoV2019 with ACE2.pic.twitter.com/Zsx3rvoMKD

      9 replies 29 retweets 69 likes
      Show this thread
    2. David Peck‏ @overseasdem Feb 12
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      Replying to @nanogenomic

      With #COVI19 found in intestinal tract; urine and feces in the largest study to date, would you expect similar binding in the gut, or liver?

      4 replies 1 retweet 4 likes
    3. Andre Watson  🧬 💊 💉‏ @nanogenomic Feb 12
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      Replying to @overseasdem

      #ACE2 is expressed most highly in the intestines and GI. It’s also a secreted protein which may suggest that it coats the virus and then interacts with other proteins involved in the renin-angiotensin-aldosterone cascade. Check out ACE2 tissue expression https://www.proteinatlas.org/ENSG00000130234-ACE2/tissue …

      5 replies 12 retweets 29 likes
    4. This Tweet is unavailable.
    5. Andre Watson  🧬 💊 💉‏ @nanogenomic Feb 12
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      Replying to @pychiatrist1972 @overseasdem

      Quite possible

      2 replies 1 retweet 5 likes
    6. Andre Watson  🧬 💊 💉‏ @nanogenomic Feb 12
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      Replying to @nanogenomic @pychiatrist1972 @overseasdem

      Gotta look at expression profiles of all systems/tissues/organs where ACE2-associated proteins express in

      1 reply 1 retweet 5 likes
    7. This Tweet is unavailable.
    8. Andre Watson  🧬 💊 💉‏ @nanogenomic Feb 12
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      Replying to @pychiatrist1972 @overseasdem

      I don’t think it’s as much ACE2 as ACE2 co-complexes, at least that is my intuition based on the expression profile. And maybe lung enrichment in the endothelial cells etc but doesn’t seem to be the case based on the RNA-Seq data I’ve seen so far

      1 reply 3 retweets 4 likes
    9. Andre Watson  🧬 💊 💉‏ @nanogenomic Feb 12
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      Replying to @nanogenomic @pychiatrist1972 @overseasdem

      My hypothesis would be that ACE2 coats the virus and then leads to an “ACE2 stealth protein corona” on the viral surface

      4 replies 4 retweets 4 likes
    10. This Tweet is unavailable.
      𝓓𝑎𝑛𝑖𝑒𝑙𝑙𝑒 𝓕𝑜𝑛𝑔, 𝕖𝕩-𝕡𝕣𝕠𝕕𝕚𝕘𝕪‏ @DanielleFong Feb 13
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      Replying to @pychiatrist1972 @nanogenomic @overseasdem

      does your simulation have (or can it produce) an output the “net binding energy” or some more complex / dynamic kinetic prediction of the rate of binding? I saw a Chinese paper earlier (will try to find) indicating early studies of the structure didn’t see efficiency vs SARS

      4:28 PM - 13 Feb 2020
      1 reply 0 retweets 0 likes
        1. Andre Watson  🧬 💊 💉‏ @nanogenomic Feb 13
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          Replying to @DanielleFong @pychiatrist1972 @overseasdem

          Yes it does this for each amino acid in terms of Gibbs free energy

          0 replies 0 retweets 2 likes
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