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Likely broken font configuration with applications using different versions of the font rendering dependencies. If that's the official Chrome package, these dependencies are bundled and will be different than the OS versions. Most distributions link the system ones for Chromium.
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No, but it's quite possible one of them is respecting settings from something like GTK or GNOME configuration and the other is ignoring them. Chromium and Firefox both have quirky desktop Linux integration because there's no standard way to do a lot of the things they want.
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Main reason I use not just on my workstations but on all the GrapheneOS servers is because I don't have to spend time debugging downstream changes. Does mean when upstream doesn't have good defaults, it's all on you to figure out how to set things up properly. I prefer that.
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One thing that's worth doing for everyone is running `fc-match sans`, `fc-match sans-serif` and `fc-match monospace` and making sure those are 3 high quality fonts you personally like. Also nice to get rid of as much as possible so you fall back to those as often as possible.
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I'm perfectly happy installing Source Sans Pro / Source Serif Pro / Source Code Pro and using gist.github.com/thestinger/d9d. Linux font rendering peaked when the perfectionist working on Infinality was around with their complex patches and configurations but it all bitrotted away.