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Prikvačeni tweet
Why
#testis /#meiosis ? It's a transcriptionally unique tissue (see PCA from mouse cell atlas data below), many tissue specific genes & male sex-chrom inactivation. It's also important for fertility, evolution and genetic diversity (due to recombination & independent assortment)pic.twitter.com/l8AHUnTAJt
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Daniel Wells proslijedio/la je Tweet
This handy figure from
@ensembl shows that the GulO gene was lost from the primate lineage between 67 and 78 million years ago so "hypoascorbemia" is a genetic disease shared by all haplorhines (dry nosed monkeys) https://en.wikipedia.org/wiki/Haplorhini http://jan2020.archive.ensembl.org/Mus_musculus/Gene/SpeciesTree?collapse=41621410%2C41621428%2C41621435%2C41621418%2C41621407%2C41621429%2C41621370%2C41621365%2C41621475;db=core;g=ENSMUSG00000034450;r=14:65986786-66009207;t=ENSMUST00000059970 …pic.twitter.com/FbndwY8M7H
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Daniel Wells proslijedio/la je Tweet
A warm welcome to our four new starters this week, who will be supporting our growing science, HR and operations teams. Fantastic to have you onboard in this exciting year ahead!pic.twitter.com/KDNEth2LtM
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Daniel Wells proslijedio/la je Tweet
A nice radial
#microtubule array in this cell. Microtubules labeled by DCX-GFP, and growing ends of MTs labelled by EB1-mCherry,#microscopy,#science,#almost_fluorescent_friday,#cells_are_amazing_machinespic.twitter.com/YbhLJA7HMUPrikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Daniel Wells proslijedio/la je Tweet
So - we might have the entirely weird, unscientific world where one bans making more precise, less unforseen side effects, indistinguishable from "traditional" approaches because (basically) it involves modern genetics, but continues to allow old, clumsy, radiation based schemes
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Daniel Wells proslijedio/la je TweetHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi
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Daniel Wells proslijedio/la je Tweet
This makes me reflect: I have never had data or code peer-reviewed, except in data articles, even though the data and the code are supposedly what give credence to my claims. Instead, what is reviewed is the manuscript containing my narrative interpretation of the results (2/n)
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Daniel Wells proslijedio/la je Tweet
With
@maximilianh we're happy to release the UCSC Repeat Browser, a tool we've been using internally to analyze repetitive elements in human and primate genomes. We use it to examine conflict between KRAB Zinc Finger Proteins and LINE-1 elements.https://www.biorxiv.org/content/10.1101/429613v2 …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Daniel Wells proslijedio/la je Tweet
This paper is quite the rollercoaster https://twitter.com/healthstatsdude/status/1201568752095158272 …pic.twitter.com/RpJRWtJYCv
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Daniel Wells proslijedio/la je Tweet
Applications open for the Wellcome Trust PhD programme in Genomic Medicine and Statistics at Oxford. I did this programme and can say Oxford is undoubtedly one of the best places in the world to study genomics:https://www.well.ox.ac.uk/work-and-study/gms-dphil-programme …
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Daniel Wells proslijedio/la je Tweet
Taking a longterm view
@uk_biobank - a lesson for research investment (thanks to@The_MRC@wellcometrust et al): 4 yrs from proposal to 1st participant; 8 yrs to full enrolment; 13 yrs to 1st publications; ~20 yrs to an explosion of scientific discovery https://www.sciencemag.org/news/2019/01/huge-trove-british-biodata-unlocking-secrets-depression-sexual-orientation-and-more …pic.twitter.com/jd4w1oIh6D
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Daniel Wells proslijedio/la je Tweet
Our work on a new source of sperm heterogeneity is finally up on biorxiv: https://biorxiv.org/cgi/content/short/846253v1 … Bottom line, we think we've found a set of mammalian genes enabling natural selection between sperm that is far more prominent than we guessed. Tweet summary to follow:
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Daniel Wells proslijedio/la je Tweet
New work with
@keurcien,@mblum_g,@John_J_McGrath and@bvilhjal available in preprint! We present some PCA-related analyses (mostly in the@uk_biobank), some pitfalls associated with these analyses, and (very) efficient implementations of solutions. --> thread 1/nhttps://twitter.com/biorxiv_genetic/status/1195054871034105857 …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Daniel Wells proslijedio/la je Tweet
Wow.
#ImageForensics Level: Outrageous. Paper states that patient got cured from his skin lesions. Left: before treatment. Right: 6 months after treatment. Published in Int J Oral Maxillofac Surg. HT:@DrVanDamme What do y'all think?pic.twitter.com/TD1hG1bKru
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Daniel Wells proslijedio/la je Tweet
Another ZCWPW1 paper https://doi.org/10.1101/836023 , here from the Liu group, has hit biorXiv! That makes 3 in the last fortnight, with our preprint https://doi.org/10.1101/821678 and the
@todd_macfarlan preprint https://doi.org/10.1101/821603 . Hopefully this gene is feeling properly loved at last.Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Daniel Wells proslijedio/la je Tweet
*One ribosomal subunit yelling at the other when trying to make a protein*https://twitter.com/realDonaldTrump/status/1191367365260394499 …
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Daniel Wells proslijedio/la je Tweet
Pollution on London's Zone 1 tube mapped for the first time. An FT investigation show's just how bad the air on the tube is. Fantastic article by
@FinancialTimes'@CamillaHodgson and@lesliehook#pollution#gistribe https://www.ft.com/content/6f381ad4-fef7-11e9-be59-e49b2a136b8d …pic.twitter.com/u1bqTvU4Xq
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Daniel Wells proslijedio/la je Tweet
Our new paper on ZCWPW1, now on bioRxiv! http://biorxiv.org/cgi/content/short/821678v1 …https://twitter.com/DanielJohnWells/status/1189612805181378561 …
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See also a complementary preprint by the Macfarlan grouphttps://twitter.com/todd_macfarlan/status/1189217661084979200 …
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Daniel Wells proslijedio/la je Tweet
ZCWPW1 is recruited to recombination hotspots by PRDM9, and is essential for meiotic double strand break repair http://biorxiv.org/cgi/content/short/821678v1 …
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PRDM9 deposits two histone marks, but what recognises them? Read our new preprint about ZCWPW1! https://www.biorxiv.org/content/10.1101/821678v1 …pic.twitter.com/2WFbevzJv6
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