Daniel J Drucker

@DanielJDrucker

Daniel J Drucker is a clinician scientist in Toronto who studies peptide and incretin hormones, diabetes, obesity and gastrointestinal disorders

Toronto
Vrijeme pridruživanja: svibanj 2011.

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  1. The Januvia/Sitagliptin franchise, which produced $5.5B USD sales in 2019, including a Q4 of $1.4B USD, will stary for now in "old Merck" and not be spun off into NewCo

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  2. The medical interventions, similar to surgery, face barriers to reimbursement. This reflects a need to understand the medical importance of obesity and to demonstrate value of and comorbidities disorders

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  4. Are ECVs meaningful contributors to human pathophysiology? More difficult to assess

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  5. More liver-adipose communication during fat loading via Ggpps and extracellular vesicles

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  6. Lost in Translation. Targeting CXCR1/2 Does Not Improve Insulin Secretion After Pancreatic Islet Transplantation: A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial in Type 1 Diabetes

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  7. Lp(a) is a significant risk factor for macrovascular disease, albuminuria, and calcified aortic valve disease in patients with type 1

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  8. True, true not-related 1) SARS-CoV strains use ACE2 to gain entry into the cell 2) Genetically determined lower ACE levels associated with a lower risk

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  10. Knowing when to make a fuss over VUS. "Functional evaluation of the HNF1A variants is necessary to better predict the pathogenic effects and to improve the diagnostic interpretation and treatment"

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  12. Lipidomicspalooza in young men during OGTT-Some (213) and (199) lipid species associated with HOMA-IR and insulin AUC respectively. Did someone say biomarkers?

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  13. Looking for translational progress in “the mechanisms of microbiota-related functions in health and disease and their clinical application”

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  14. proslijedio/la je Tweet
    prije 17 sati

    The TrialNet team have validated a simple measure of pancreatic function in . This measure has the potential to do away with 2 h meal tests and simplify the monitoring of the effects of immune therapy

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  16. New Small Molecule Lead Candidates for Targeting the the DYRK1A-NFAT Pathway to Augment Human β-Cell Regeneration

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  17. "Ins2, Iapp, Gcg, Sst, Pcsk1, and Pcsk2 mRNA transcripts were detected in islet macrophages but not in peritoneal macrophages and microglia. This may result from engulfment of secretory vesicles (Ying et al., 2019) or phagocytosis of endocrine cells"

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  18. A Resource for Distinct Transcriptional Macrophage Responses to Nutritional Availability

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  19. Transcription Factor Binding Site Bookmarking During Liver Development "Fire Hydrants" Marking Future Gene Activation

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