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The Januvia/Sitagliptin
#diabetes#T2D franchise, which produced $5.5B USD sales in 2019, including a Q4 of $1.4B USD, will stary for now in "old Merck" and not be spun off into NewCohttps://twitter.com/cfromhertz/status/1225025841710686209 …
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The medical
#obesity interventions, similar to#bariatric surgery, face barriers to reimbursement. This reflects a need to understand the medical importance of obesity and to demonstrate value of#weightloss and comorbidities#NASH#CVD#sleep disorders#cancer#arthritispic.twitter.com/96wkFKwzYF
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Some perspectives this am via 2019 reporting
@novonordisk GLP-1 remains a prominent component of the ##T2D#obesity franchise https://www.novonordisk.com/content/dam/Denmark/HQ/investors/irmaterial/investor_presentations/2020/20200205_Q4%202019%20roadshow%20presentation.pdf …pic.twitter.com/JOGv3sCYsl
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Are ECVs meaningful contributors to human pathophysiology? More difficult to assesspic.twitter.com/PzU15wA5bK
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More liver-adipose communication during fat loading via Ggpps and extracellular vesicles
@NatureCommshttps://www.nature.com/articles/s41467-020-14450-6 …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Lost in Translation. Targeting CXCR1/2 Does Not Improve Insulin Secretion After Pancreatic Islet Transplantation: A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial in Type 1 Diabeteshttps://care.diabetesjournals.org/content/early/2020/01/28/dc19-1480 …
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Lp(a) is a significant risk factor for macrovascular disease, albuminuria, and calcified aortic valve disease in patients with type 1
#diabetes#T1D#CVD#Heartdiseasehttps://care.diabetesjournals.org/content/early/2020/01/30/dc19-1398 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
True, true not-related 1) SARS-CoV strains use ACE2 to gain entry into the cell 2) Genetically determined lower ACE levels associated with a lower risk
#T2Dhttps://care.diabetesjournals.org/content/early/2020/01/30/dc19-1973 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
What Does Autoantibody Reversion Mean? A Reduced Risk For
#T1D@JDRF@T1D_TrialNethttps://care.diabetesjournals.org/content/early/2020/01/30/dc19-1731 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Knowing when to make a fuss over VUS. "Functional evaluation of the HNF1A variants is necessary to better predict the pathogenic effects and to improve the diagnostic interpretation and treatment"
#Diabetes#MODYhttps://academic.oup.com/jcem/jcem/advance-article-abstract/doi/10.1210/clinem/dgaa051/5722353#.Xjnd_JcyVgs.twitter …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Are
#weightloss responders to#bariatric surgery L cell whisperers?https://academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgaa061/5722168#.XjndPVodR70.twitter …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Lipidomicspalooza in young men during OGTT-Some (213) and (199) lipid species associated with HOMA-IR and insulin AUC respectively. Did someone say biomarkers?https://academic.oup.com/jcem/jcem/advance-article-abstract/doi/10.1210/clinem/dgaa054/5722002#.XjncknVQ_mI.twitter …
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Looking for translational progress in “the mechanisms of microbiota-related functions in health and disease and their clinical application”
@scisignalhttps://stke.sciencemag.org/content/13/617/eaba9911 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Daniel J Drucker proslijedio/la je Tweet
The TrialNet team have validated a simple measure of pancreatic function in
#T1D. This measure has the potential to do away with 2 h meal tests and simplify the monitoring of the effects of immune therapy@T1D_TrialNet@WEHI_research@TheRMH http://bit.ly/31mCgeX pic.twitter.com/WSfnXDOzEK
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Lipids in the Bone Marrow: An Evolving Perspective
@Cell_Metabolismhttps://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30518-2?dgcid=raven_jbs_etoc_email#.Xjm7j-LPeQg.twitter …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
New Small Molecule Lead Candidates for Targeting the the DYRK1A-NFAT Pathway to Augment Human β-Cell Regeneration
#Islets#T1D@JDRF@JMedChemhttps://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.9b01379#.Xjmbh5GJ5H4.twitter …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
"Ins2, Iapp, Gcg, Sst, Pcsk1, and Pcsk2 mRNA transcripts were detected in islet macrophages but not in peritoneal macrophages and microglia. This may result from engulfment of secretory vesicles (Ying et al., 2019) or phagocytosis of endocrine cells"pic.twitter.com/kLxX8a8ZX6
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A Resource for Distinct Transcriptional Macrophage Responses to Nutritional Availability
@CellReportshttps://www.cell.com/cell-reports/fulltext/S2211-1247(20)30014-0#.XjmSuWRWnbk.twitter …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Transcription Factor Binding Site Bookmarking During Liver Development "Fire Hydrants" Marking Future Gene Activation
@CellReportshttps://www.cell.com/cell-reports/fulltext/S2211-1247(20)30015-2#.XjmR9Q_xw38.twitter …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
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