If you do that on a plate with attached antibodies, can you gradient separate cells based on surface markers? #Immunopanning
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Interesting idea. Electrotaxis is a signaling process that involves the cytoskeleton rather than directly moving cells by electrical forces. Antibody binding might not allow proper migration...
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This is so cool!! I will have to look at the paper, but what is this "bioelectricity" you are using??
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It’s called Electrotaxis and it’s a pretty nifty and weird phenomenon where parts of the chemotaxis network are co-opted during DC field stimulation. We are working on getting a Wikipedia page up on it, but check out work from Min Zhao and Colin McCaig.
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Would this work for bacteria too?
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There is some data in bacteria but the mechanism is thought to be pretty different, I think...
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Very cool. There seem to be some low or non-responders. How are they different from the rest?
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Great question—we call them ‘straggler cells’ and we’re not sure yet what makes them so. We only see this behavior with primary cells right now and they can be a bit weird. We’re looking into it!
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Can you guide the cells through a labyrinth mimicking infiltration? Or can you use it to "print" cells.
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Active guidance in a maze might work, but not sure we have enough control for printing style resolution. Maybe more like ‘sculpting’ than additive or subtractive assembly.
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