Not sure if this is what you meant, but if we remain as a single planet culture/civilisation/species, it’s clear to me our days are numbered.
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I was thinking more along the lines of whether civilizations need mass die-offs to maintain their health, but it also applies to sending small groups of colonists to other planets, yes.
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Really what they do is replicate that process many times with different options for the single cell, so that some of the options will be suited to the current conditions. Evolution is only better than identical self-replication because of all the additional diversity available.
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I guess it also depends how rapidly & widely generations can reproduce, which is inversely related to complexity. That’s probably why microbes can still cell-divide + any mutations (though they can swap plasmid ring bits too) & have that usually be ‘enough’ to adapt.
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