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Csaba Pal Laboratory proslijedio/la je Tweet
It's time to replace λBeta in MAGE, DIvERGE and ssDNA recombineering! By analyzing 100s of proteins, we have identified 2 that allow E.coli oligo-recombineering with up to 50% efficiency, increase multiplexability + allow MAGE in P. aeruginosa https://www.biorxiv.org/content/10.1101/2020.01.14.906594v1 …pic.twitter.com/2h1yPjQbia – mjesto: Harvard Medical School New Research Building
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Csaba Pal Laboratory proslijedio/la je Tweet
Our,
#ERCPoC-supported, US patent application, "Mutagenizing intracellular nucleic acids" with@Csaba_Pal_Lab,@balint_kintses &@BCsorgo is now available online https://patents.google.com/patent/US20200017850A1/en …#biotech#DirectedEvolution#enzyme#synbio#DNApic.twitter.com/fUMNgElWaZ
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Csaba Pal Laboratory proslijedio/la je Tweet
Looking for a Summer Research
#Internship position in#SyntheticBiology / Directed Evolution@harvardmed? If yes and you are interested in synthetic genomes + applying the latest tools for DNA-editing, including MAGE, DIvERGE, and#CRISPR, please reach out to us or DM me.pic.twitter.com/qzV67kGsKr
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Csaba Pal Laboratory proslijedio/la je Tweet
This is BIG, because the study systematically investigates for the first time whether the use of AMP therapeutics could select for resistance to human host-defense
#peptides, incl defensins - and shows that cross-resistance is preventable by rationally choosing Mode-of-Action.Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Csaba Pal Laboratory proslijedio/la je Tweet
Glad to share our new paper- Chemical-genetic profiling reveals limited cross-resistance between antimicrobial peptides with different modes of action
@NatureComms,@Csaba_Pal_Labhttps://www.nature.com/articles/s41467-019-13618-z …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Csaba Pal Laboratory proslijedio/la je Tweet
Read it, RTit, tell your friends and students about it, make your dog read it... this paper changes bacterial genetics and evolution.https://twitter.com/AlvSanMillan/status/1202151649952837632 …
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Csaba Pal Laboratory proslijedio/la je Tweet
Our new circular DNA paper shows that ageing yeast produce extra copies of genes that are useful in the current environment on extrachromosomal circleshttp://PLoS.io/2rYSWv5
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Congratulations to
@marczikkely for receiving a 10 Month University ScholarshipHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Congrats Bálint! Great piece of work!
@BCsorgohttps://twitter.com/BCsorgo/status/1202301620572147713 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Great collaborative project with the group of
@vdlorenzo_CNB is out in ACS Synth. Biol.https://twitter.com/vdlorenzo_CNB/status/1202243245058732037 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Csaba Pal Laboratory proslijedio/la je Tweet
New paper is out by
@Csaba_Pal_Lab in the@ACSSynBio .@AkosNyerges#Pseudomonas#optogenetics#CcaSR#recombineering#interoperabilityhttps://pubs.acs.org/doi/10.1021/acssynbio.9b00375 …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Csaba Pal Laboratory proslijedio/la je Tweet
Ron Milo
@WeizmannScience did it again
https://www.cell.com/cell/fulltext/S0092-8674(19)31230-9 … Autotrophic growth of E. coli on CO2 as sole C source. True, with a little help of formate to generate reductive currency, but still an awesome breakthrough
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Csaba Pal Laboratory proslijedio/la je Tweet
Our OrthoFinder 2 paper is now out! A big thanks for all the support and encouragement we've had from everyone. Our goal was to extend OrthoFinder to provide a complete, automatic gene tree based ortholog analysis that only required gene sequences as input.
@Steve__Kellypic.twitter.com/tit2hofUie
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Csaba Pal Laboratory proslijedio/la je Tweet
please RT: Abstract submission now open for
#SMBE2020 Population genomics, experimental evolution, polyploidy, hybridization, protein evolution, new genes, cancer, mutation load, structural variation... Visit the portal and submit your best work http://smbe2020.org/ pic.twitter.com/zZT2ptIWsD
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Csaba Pal Laboratory proslijedio/la je Tweet
An awesome genetic strategy for DNA hyperdiversification of specific genomic segments in vivo with a T7 RNApol fused to cytosine deaminases targeted to xmosomal sites delimited by a T7 promoter and a dCas9/gRNA binding sequence https://www.biorxiv.org/content/10.1101/850974v1 …pic.twitter.com/zz6kCSMZjl
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Csaba Pal Laboratory proslijedio/la je Tweet
Predicting
#Antibiotic Resistance with Experimental Evolution: **A Large-Scale Whole-Genome Comparison Shows that Experimental Evolution in Response to Antibiotics Predicts Changes in Naturally Evolved Clinical#Pseudomonas aeruginosa ** https://aac.asm.org/content/63/12/e01619-19 …#AMRpic.twitter.com/QyQFv9d1CL
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Csaba Pal Laboratory proslijedio/la je Tweet
A new antibiotic selectively kills Gram-negative pathogens | Naturehttps://www.nature.com/articles/s41586-019-1791-1 …
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Csaba Pal Laboratory proslijedio/la je Tweet
https://www.nature.com/articles/s41592-019-0638-x … Ralserlab is proud to present DIA-NN, a software & algorithm suite that is easy to use, and that allows you to deconvolute proteome experiments as fast as a few minutes. We have precisely quantified > 4000 proteins < 5 mins. More to come soon :-)
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Csaba Pal Laboratory proslijedio/la je Tweet
Our latest article, "Dual Escherichia coli DNA Gyrase A and B Inhibitors with
#Antibacterial Activity" that describes the first step towards novel multi-targeting DNA Gyrase inhibitor#Antibiotics, is now online at https://onlinelibrary.wiley.com/doi/abs/10.1002/cmdc.201900607 …@Csaba_Pal_Lab@SysbioSHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Our article: Dunai A. et al., eLife, 2019, has been recommended in F1000Prime as being of special significance in its field by F1000 Faculty Member José Luis Martínez. You can read Dr Martínez's recommendation here https://f1000.com/prime/736436494?subscriptioncode=ad5e4b0b-3a60-4d9b-a0f7-85c1a9bd8037&utm_medium=email&utm_source=prime_ypp ….
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