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There appears to be a protocol deviation in the TOGETHER trial: "Expected hospital stay <= 5 days". Why was this conditionality introduced as it is near impossible for a clinician to assess whether a possible hospital stay will exceed 5 days or not?pic.twitter.com/ZjEQKwtjhq
That strange decision to pre-judge the hospitalization risk (which is exactly what you are trying to discover and measure) decreases the event rate and the probability of the drug to show an effect.
Protocol deviations are always potential red flags.
The "Expected hospital stay <= 5 days" conditionality is nowhere to be seen in the original protocol.
Post-hoc data gerrymandering to allow a small win for Fluvoxamine and a miss for Ivermectin?
https://twitter.com/search?q=from%3Acovid19crusher%20full%20protocol&src=typed_query …
Here’s an excerpt from the protocol. There is no mention of “expected hospital stay <=5 days.” Is this a protocol deviation or scientific misconduct?pic.twitter.com/ZbmU8Wt5Rg
Look at the published HCQ paper. Look at the exclusion criteria they claim in the paper. Look at the exclusion criteria in the protocol. See something strange?
I still get shocked by the language that gets approved by these journals when it is statistically incorrect: “no effect whatsoever” is very different from “insufficient evidence to accept hypothesis”. Ironically, even a bad IVM study shows a positive effect.
I noticed that too, ... but I had no idea what to make of it. At least it seemed consistent across the trials.
So does that include both the "you'll be out soon" and the "not going to last a week" crowds? 
/s
Wowza. If the original parameters didn’t expressly incorporate adaptive design, looks like the folks on the design committee have some explaining to do…preferably under oath.
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