1. p16 protein, assessed by IHC, is lost in 53% of 384 chordoma samples analysed, including metastatic. 2. Copy number loss is the most frequent CDKN2A genetic alteration, detected in 83% of samples by FISH, and is more common in older patients and in local recurrences.
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3. However, CDKN2A homozygous deletion only accounts for 33% of p16-neg cases, suggesting that loss of protein expression might be achieved via epigenetic or post‐transcriptional regulatory mechanisms, yet to be uncovered.
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4. Multiple samples from the same patients show that p16 is heterogeneously expressed in chordomapic.twitter.com/ua4Aa1Yld3
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5. We suggest that using p16 IHC or CDKN2A FISH to predict behaviour in chordoma only provides limited information and is not recommended in a clinical setting
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Congratulations, Lucia. Thank you for your work!
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