Sewing-machine insertion of flexible electrodes via small holes. Good progress on channel count + insertion, building on @m8ta's work. Also nice chip+packaging. Hard stuff. Much depends on gliosis, but Chong Xie's results promising. Laser would indeed be preferable to drill. 1/4https://twitter.com/antonioregalado/status/1151335093354582016 …
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Optical readout has problems too. Need to express sensor genes stably and safely. Can't see more than 200um deep without 2-photon, which is not getting minaturized to a wearable probably ever. Even with 2p, can't get over 700um deep. Implantable lenses cause huge damage...
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2-photon and sensor genes are not the only options here...
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if you’re putting electronics inside the skull, flexible electrodes will lose long term to optical readout. Nearly all hard problems unsolved here, animal model doesn’t translate (vasculature, insertion depth), hermeticity, reg burden unproven. Feel like we’ve been here...