Christopher Toepfer

@ChrisToepfer

Sir Henry Wellcome Fellow & . Researching Inherited & acquired heart disease.

Oxford, UK
rdm.ox.ac.uk/people/christo…
Vrijeme pridruživanja: siječanj 2017.
37 fotografija ili videozapisa Fotografije i videozapisi

Tweetovi

Blokirali ste korisnika/cu @ChrisToepfer

Jeste li sigurni da želite vidjeti te tweetove? Time nećete deblokirati korisnika/cu @ChrisToepfer

  1. Prikvačeni tweet
    27. sij

    Our paper on the causes of Hypertrophic Cardiomyopathy (HCM) in patients carrying myosin variants (MYH7) examined the fundamental mechanisms that drive HCM and how they predict clinical outcomes. Bonus gif of HCM cell beating in a dish.

    9 replies 59 proslijeđenih tweetova 166 korisnika označava da im se sviđa
    Prikaži ovu nit
    Prikaži ovu nit
    Poništi
  2. proslijedio/la je Tweet
    1. velj

    Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy. Circulation 2020

    1 proslijeđeni tweet 3 korisnika označavaju da im se sviđa
    Poništi
  3. 31. sij

    Amazing. !

    New emoji got us like…
    2 korisnika označavaju da im se sviđa
    Poništi
  4. 30. sij

    A lovely write-up explaining our findings from our recent paper on MYH7 variants by . Healthy (L) and HCM (R) iPSC derived cardiomyocyte beating.

    5 proslijeđenih tweetova 17 korisnika označava da im se sviđa
    Poništi
  5. 27. sij

    Thanks to for the beautiful write up!

    1 reply 2 proslijeđena tweeta 5 korisnika označava da im se sviđa
    Prikaži ovu nit
    Prikaži ovu nit
    Poništi
  6. 27. sij

    Thanks to . This work was performed by at , , , at and more. Big thanks to .

    1 reply 6 korisnika označava da im se sviđa
    Prikaži ovu nit
    Prikaži ovu nit
    Poništi
  7. 27. sij

    Human tissue from HCM patients showed reduced ‘off’ myosin, which was restored by the same myosin blocking compound. Unfortunately, patients with reduced ‘off’ myosin have more HF and AF. The good news is that we understand why and have a possible way to correct this imbalance.

    1 reply 1 proslijeđeni tweet 5 korisnika označava da im se sviđa
    Prikaži ovu nit
    Prikaži ovu nit
    Poništi
  8. 27. sij

    Too much ‘on’ myosin also made cells grow bigger and use more oxygen, and by re-balancing ‘off’ myosin these cellular changes went away.

    1 reply 1 korisnik označava da mu se sviđa
    Prikaži ovu nit
    Prikaži ovu nit
    Poništi
  9. 27. sij

    Too much ‘on’ myosin caused hypercontractility and poor cellular relaxation, which could be corrected by restoring appropriate levels of ‘off’ myosin.

    1 reply
    Prikaži ovu nit
    Prikaži ovu nit
    Poništi
  10. 27. sij

    Our experiments showed that 'off' myosin could be restored in human cells made from stem cells. This can be done by treating with a compound that binds to myosin and slows its ability to use ATP, the cellular source of energy.

    1 reply
    Prikaži ovu nit
    Prikaži ovu nit
    Poništi
  11. 27. sij

    Secondly, we observed that many mutations in myosin that cause HCM may interfere with the myosin off-state; switching them inappropriately on. This could account for clinical features of HCM in these patients.

    1 reply 1 korisnik označava da mu se sviđa
    Prikaži ovu nit
    Prikaži ovu nit
    Poništi
  12. 27. sij

    Firstly, we found that hibernation in mammals caused myosin, the molecular motor of muscle contraction, to switch off in the heart. We proposed that humans have this same switch in their hearts, a mechanism conserved in evolution.

    1 reply 1 proslijeđeni tweet
    Prikaži ovu nit
    Prikaži ovu nit
    Poništi
  13. proslijedio/la je Tweet
    23. sij

    Our big news for the day: 's CureHeart project is one of only 4 shortlisted for 's £30 million research prize

    12 proslijeđenih tweetova 27 korisnika označava da im se sviđa
    Prikaži ovu nit
    Prikaži ovu nit
    Poništi
  14. 20. sij

    Great talk today at OCMR by . Learning lots about determining variant pathogenicity in HCM.

    5 korisnika označava da im se sviđa
    Poništi
  15. 29. stu 2019.

    Introducing Harvie the lab as the new lab 🔬 🧫 mascot!

    1 proslijeđeni tweet 22 korisnika označavaju da im se sviđa
    Poništi
  16. 31. lis 2019.

    Science Halloween in the lab 🧫🎃 with CRISPR Croc.

    7 korisnika označava da im se sviđa
    Poništi
  17. proslijedio/la je Tweet
    21. lis 2019.

    Prime Editing... this is so brilliant it just blew my small brain!

    Korisnici , , i
    8 proslijeđenih tweetova 23 korisnika označavaju da im se sviđa
    Poništi
  18. 17. lis 2019.

    One of the first days of getting things up and running in the lab. This is a good omen right? 🌈

    20 korisnika označava da im se sviđa
    Poništi
  19. 8. lis 2019.

    Sarcomere in stained glass by Joel Kowit.

    49 korisnika označava da im se sviđa
    Poništi
  20. 3. lis 2019.

    BHF CRE annual symposium. Spot the TTN-GFP Looking forward to the talks.

    1 reply 1 proslijeđeni tweet 13 korisnika označava da im se sviđa
    Poništi

@ChrisToepfer još nije objavio nijedan Tweet.

Čini se da učitavanje traje već neko vrijeme.

Twitter je možda preopterećen ili ima kratkotrajnih poteškoća u radu. Pokušajte ponovno ili potražite dodatne informacije u odjeljku Status Twittera.

    Možda bi vam se svidjelo i ovo:

    ·