A #SARSCoV2 variant carrying the #Spike #protein amino acid change #D614G is potentially associated with greater #infectivity and higher #viral loads. Online now! bit.ly/2Zwpvh9
For all #coronavirus research, visit cell.com/2019-nCOV #COVID19
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Cell aims to publish the most exciting and provocative research in biology. Posts by Scientific Editors on the Cell Editorial team.
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We are horrified and angered by the brutality repeatedly faced by Black Americans, and we stand in solidarity with those protesting violence against Black Americans and the systemic racism and discrimination that feed it. Black lives matter. #BlackLivesMatter
Out now! A #comprehensive multi-omics analysis from 59 #astronauts provides insight into important #biological mechanisms affected by #spaceflight. bit.ly/3fwQ79z ☄️🛰️🚀
Online now! RNA promotes the formation of spatial compartments in the nucleus
#sciencetwitter #RNA
bit.ly/3ENFGcP
Out now! #Cancer cells can enter a quiescent state in response to #chemotherapy and subsequently emerge rejuvenated bit.ly/399klMV
Our Juneteenth-themed issue is out! It features several articles highlighting the voices, perspectives and stories of over 70 outstanding Black scientists!
cell.com/cell/current
On the cover, Mays et al. describe the historical context of the Juneteenth holiday in the… Show more
Online now! #Clinical trial #data suggests that BCG #vaccination is safe and can #protect the #elderly against #infections bit.ly/3lBToaf
A new technique, #TrimAway, directly degrades endogenous proteins in mammalian cells within minutes of application (without a need for prior modification of the genome or mRNA)! Free article --> bit.ly/2zOk81E
In the latest issue! Migrating cells selectively remove damaged mitochondria to maintain homeostasis in a process called mitocytosis
bit.ly/3wHKSLB
Online now! Stereo-seq combines DNA nanoball patterned arrays and tissue RNA capture to achieve large field-of-view spatial transcriptomics at cellular resolution!
#sciencetwitter #singlecell
bit.ly/3yfFZgG
New Resource online now! A single-cell atlas of chromatin accessibility in the human genome 🧬🧬
#sciencetwitter #chromatin #singlecell
bit.ly/3D6bhGp
Online now! A mechanistic understanding of the #origin and #adaptive function of IL-6 in #acute #stress bit.ly/2ZqZ38v
Now online! Neuronal ensembles in the mouse insular cortex that are activated during distinct inflammatory conditions, are capable of modulating peripheral immunological responses
#neuroscience
bit.ly/3H2rJKc
In the latest issue! The gripping story of integrins
SHARE-seq is a highly #scalable approach to measure both #chromatin accessibility and #gene #expression in the same #cell. New Resource online now! bit.ly/2TxI5mJ
An entire fly brain in electron microscopy, at the resolution of individual synapses: &co 's work is online and 🔓
cell.com/cell/abstract/
Explore the data further here: temca2data.org
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How can we measure the #memory of a single #cell? MemorySeq can reveal new forms of #biological memory by identifying slowly fluctuating #gene expression states in rare single #cells. Online now! bit.ly/3hJs478
Now online! Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2 dlvr.it/SJcqY7
Online now! This gene expression map in mature C. elegans captures all 302 neurons and deciphers the molecular basis for cell heterogeneity, connectivity, and function
#neuroscience
bit.ly/3jVMwpA
Our new issue is out! Featuring synthetic mammalian cellular signaling circuits, local hyperthermia therapy to treat obesity, and a reconstruction of mouse visual cortex!
bit.ly/37FxrED
#newissue #sciencetwitter
New Article now online: Lymph nodes are innervated by a unique population of sensory neurons with immunomodulatory potential zpr.io/HeWSS
Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins hubs.li/Q01fBBP20
In the latest issue! Advancing natural killer therapies against cancer
Online Now: Structures of human #antibodies derived from recovered individuals that are bound to the #SARSCoV2 spike reveal common epitopes and recurrent features #COVID19 bit.ly/3hQkEzX
Online now! A #natural single-guide #RNA that directs Cas9 to #transcriptionally repress its own #promoter bit.ly/2JXD71l
#ACE2 expression is stimulated by IFN-α in human epithelial cells suggesting #SARSCoV2 can exploit lung tissue protective mechanisms for cellular entry bit.ly/3bE5nPb Now
#coronavirus research, visit cell.com/2019-nCOV
#COVID19
Two new studies on #Omicron tell us how individuals vaccinated 3x with mRNA vaccines or those with mixed vaccination may be better protected. What does this mean for the #COVID19 pandemic? Read more: bit.ly/3EDxv2i bit.ly/32M3FM5 #SARSCoV2
The new issue is out! Featuring the deep population history of northern East Asia, cardioids that recapitulate chamber-like structures, and RNAs modified with N-glycans!
#NewIssue
bit.ly/3vfQWcN
Out now! A single-cell atlas of gene expression and chromatin accessibility of the human developing cortex during mid-gestation identifies prioritized mutations for Autism Spectrum Disorder
#neuroscience #developmentalbiology
@PascaStanford
bit.ly/3Es33t6
Now online! Neurodegeneration in Parkinson’s disease occurs via PAAN/MIF nuclease activity. Inhibition of this nuclease with a small molecule inhibitor prevents this neurodegeneration!
#sciencetwitter #neuroscience 🧠🧠
bit.ly/3wkcwzG
Cell stands with our Black readers, reviewers, authors, and colleagues, against racism and police brutality. We are committed to amplifying their voices, to educating ourselves, and to finding ways that we can do better. #BlackLivesMatter
Our editorial: info.cell.com/s0092-86742030
We are sad to learn of Dr. Angelika Amon's passing. We wish her family, members of her lab and those close to her strength during this difficult time. Her remarkable legacy, advocacy for women in science and guidance as an advisory board member for the journal were invaluable.
Online now! Multiplexed FISH in thick tissue sections, with deep-learning based 3D segmentation, enables characterization of the spatial organization for different cell types in defined brain regions
#sciencetwitter 🧠🧠
bit.ly/3drutTW
For the 2nd week, the Cell editorial recommended reads from our #cancer Special Issue start with a Review on #macrophages in #cancer and how these contribute to #tumor evolution cell.com/cell/fulltext/🧵(1/4)
Online now! A multiomics study in humans investigating the longitudinal effects of a high-fiber or fermented-food diet shows their effects on the diversity of the microbiome
#microbiology #microbiome 🦠🦠🍞🍇🧀🦠🦠
bit.ly/2UBE6cq
Online Now! High-fat #diets impair #Tcell function in the #tumor microenvironment accelerating tumor growth bit.ly/2VZoahG
Check out our new primer on #MachineLearning for #biologists including a foray into deep learning cell.com/cell/fulltext/
In the latest issue! High-fat #diets impair #T-cell function in the #tumor microenvironment accelerating tumor growth bit.ly/3aT4K6O
New Editorial online now at Cell: Science Has a Racism Problem
Now online! Small RNAs are modified with N-glycans and displayed on the surface of living cells dlvr.it/Rztqlj
Online now! Generation of the C3a complement protein fragment by #SARSCoV2 infection drives differentiation of a CD16-expressing T cell population that associates with severe #COVID19 disease outcomes
For all #coronavirus research visit cell.com/2019-nCOV
New Review online now! This review #explores the #molecular and #cellular aspects of #lung aging and how the #aging process predisposes to the #pathogenesis of pulmonary #disease bit.ly/3dxPADu
Now online! Distinct longevity mechanisms across and within species and their association with aging
Now out! Stereo-seq combines DNA nanoball patterned arrays and tissue RNA capture to achieve large field-of-view spatial transcriptomics at cellular resolution!
#sciencetwitter
bit.ly/3swLxj5
A subset of sensory #neurons are involved in an unexpected #neuroimmune mechanism that maintains cutaneous #immune homeostasis. Now online! bit.ly/3lNTXOL
How dangerous is a lack of sleep? #Sleep deprivation is associated with #lethality through accumulation of #reactive oxygen species in the #gut. Now online! bit.ly/2BpNNkv
New Resource online now at Cell: A Quantitative Proteome Map of the Human Body zpr.io/HNbcr
In the latest issue! What is cancer metabolism?
New Review online now at Cell: The Self-Organizing Genome: Principles of Genome Architecture and Function zpr.io/HMhMQ
Now online! Commensal #microbiota regulate #interferon signaling to #protect against #pathogenic #viral #infections.
bit.ly/35FMkmY
#SARSCoV2 #infection depends on #cellular heparan sulfate and #ACE2 bit.ly/3kglTIR
For all #coronavirus research and commentary, visit cell.com/2019-nCOV
#COVID19
Just brilliant! 🤩
Quote Tweet
Replying to @Elinav_Lab and @CellCellPress
I used @p5xjs to make this very nice journal cover playable. Try it here: editor.p5js.org/jmutterer/full
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Online now! Glioblastoma stem #cells deploy a myeloid mimicry program enabling #immune evasion and #tumor progression bit.ly/3a7aSac
Now online! The host immune system uses the endogenous virome to communicate with the exogenous microbiota in a multikingdom interaction that modulates tissue repair and inflammation.
#microbiome #virome🦠🦠🦠
bit.ly/3j3a8s5
New Article online now at Cell: Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19
Online now! An in vitro system to silence mitochondrial gene expression
#sciencetwitter
bit.ly/3ppqm1J
Not all about neurons! Astrocyte activation in the #hippocampus is sufficient to generate synaptic potentiation, enhance memory allocation, and improve cognitive performance beyond what can be achieved by elevating neuronal activity alone cell.com/cell/fulltext/
Online now! Single-#cell analysis of #tumor-infiltrating #Tcells in glioma #patients identifies a T-cell population co-expressing a #cytotoxicity program and NK cell receptors bit.ly/3amuRSN
#Arc, a master regulator of #synapticplasticity, contains sequence elements related to #retrotransposon Gag genes. Here, 2 studies show that Arc retains retroviral-like capsid-forming ability and can transmit mRNA between cells. bit.ly/2CVPe60 , bit.ly/2Fv8PvR
Now online : Regulatory #Tcells in the colon are transmitted across generations by maternally transferred #IgA. This multigenerational #transmission may modulate the tuning of gut #immune responses and inflammatory #disease susceptibility. bit.ly/2T2xEaS
Now online! A single transcription factor is able to regulate caste identity in ants by acting as a core transcriptional regulator in response to caste-specific hormone signaling
#ants #sciencetwitter 🐜🐜
bit.ly/2YeJvbt
Now online! Deciphering cell signaling networks with massively multiplexed biosensor barcoding dlvr.it/SDLh53
Online now! Tumor resident intracellular bacteria promote metastatic colonization in breast cancer
#microbiome #CancerResearch #sciencetwitter
bit.ly/3DR7jTh
In the latest issue! Cytotoxic CD4+ T cells eliminate senescent cells by targeting cytomegalovirus antigen
In the latest issue! Small RNAs are modified with N-glycans and displayed on the surface of living cells
#RNA #glycoRNA
bit.ly/3pH1IYo
New resource online now! Extracellular vesicle and particle #biomarkers define multiple #human #cancers
bit.ly/3gXQI3K
The balance between kinase and phosphatase activity provides a control point for gene expression that can be exploited to inhibit tumorigenesis
#cancerresearch
bit.ly/3hz3Dwq
In the latest issue! Nutrition, longevity and disease: From molecular mechanisms to interventions
SHARE-seq is a highly #scalable approach to measure both #chromatin accessibility and #gene #expression in the same #cell. New Resource in the latest issue! bit.ly/3pyazLG
New Article now online: Functional SARS-CoV-2-specific immune memory persists after mild COVID-19
In the latest issue! Macrophages at the interface of the co-evolving cancer ecosystem
Now online! An inter-organ neural circuit for appetite suppression!
#ScienceTwitter #neuroscience
bit.ly/3GGBAWm
New Resource online now! Clearing-assisted tissue click chemistry (CATCH) allows for the in vivo visualization of target-bound drug molecules and enables the identification of drug distribution and engagement in mammalian tissue
#sciencetwitter #chemistry
bit.ly/3LpD4pn
In the latest issue! Delivering the next generation of cancer immunotherapies with RNA
New resource now online! Seq-Scope achieves sub-micron resolution spatial transcriptomics, enabling the visualization of transcriptomic heterogeneity at cellular and subcellular levels
bit.ly/3pFRveR
#Cas9 can be used as a #molecular #clock to record #time and #temporal information about #biological events. Now online! 🧬⏰
bit.ly/3oDYt20
In the latest issue! The brain remembers where and how inflammation struck
Online now! Deciphering cell signaling networks with massively multiplexed biosensor barcoding
bit.ly/318VOHu
#Science has a racism problem. We acknowledged that we are part of this problem & pledged to be part of the solution. In this issue, we take a step forward, with voices from #BlackinSTEM & others who work to make science equitable & inclusive: bit.ly/2G9TVA9 #diversity
Now online! Engineered, DNA-free virus-like particles, that efficiently deliver gene editing proteins to multiple organs, are used to improve visual function in a mouse model of genetic blindness
#sciencetwitter #geneediting 🧬🐭
bit.ly/3qf8eHZ
A bidirectional #neuroimmune communication axis in #lymph nodes, where sensory #neurons not only sense lymph node #immune status but also modulate #gene expression. Online now! bit.ly/2WloEid
New Article online now at Cell: Memory Sequencing Reveals Heritable Single-Cell Gene Expression Programs Associated with Distinct Cellular Behaviors zpr.io/H7xnM
In recognition of Juneteenth, is honored to share the voices, stories and perspectives of over 70 Black scientists across several Leading Edge articles in our current issue. bitly.ws/IjCN 🧵(1/9)
In the latest issue! An in vivo neuroimmune organoid model to study human microglia phenotypes
Online now! B cells promote the differentiation of tumor-specific CD4 T follicular helper cells in a neoantigen-dependent manner, which in turn enhance CD8 T cell effector functions in a model of lung adenocarcinoma.
#cancerresearch #sciencetwitter
bit.ly/3EcLQDM
In the latest issue! Chilling with cephalopods: Temperature-responsive RNA editing in octopus and squid
Most introns are removed from human pre-mRNAs progressively in pieces rather than spliced as whole units. This has implications for understanding mechanisms and patterns of alternative splicing. Out now!
#RNA #alternativesplicing 🧬
bit.ly/34nEltf
New Perspective now online: Functional Long Non-coding RNAs Evolve from Junk Transcripts zpr.io/HuXbJ
Now online! Totipotent cells are reprogrammed from mouse pluripotent stem cells and cultured stably with high chromosomal stability and cell viability
#stemcells
bit.ly/3fbp2bW
In the latest issue! Phage therapy: From biological mechanisms to future directions
TNF-α and IFN-γ #synergize to drive the #cytokine storm and #cell death associated with #COVID19 and sepsis. Online now! bit.ly/3nCc1e6
For all #coronavirus research and commentary, visit cell.com/2019-nCOV
#SARSCoV2
BREAKING NEWS: first primates #cloned by somatic cell nuclear transfer, the method that made #DollyTheSheep --> bit.ly/2n8p3CN
In the latest issue! RNA promotes the formation of spatial compartments in the nucleus
#sciencetwitter #DNA #RNA 🧬
bit.ly/30dAq3T
Is it harder to get a Cell paper if you are a woman? In an editorial today led by our colleague Dr. we look at author breakdown for Cell papers by gender. We looked at 13000 papers between 2017-2021 (1/n) bit.ly/3gKv6cA
In the latest issue! Lymph node colonization induces tumor-immune tolerance to promote distant metastasis
