There is great concern about the potential spread of the new #SARSCoV2 variant (B.1.1.7) outside the UK. How many cases do we have to expect in Switzerland and will they spread further? Let's do some back-of-the-envelope calculations. 1/nhttps://www.ecdc.europa.eu/en/publications-data/threat-assessment-brief-rapid-increase-sars-cov-2-variant-united-kingdom …
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But there is more to it. The equation above assumes that the number of secondary cases are geometrically distributed (k = 1). However,
#SARSCoV2 exhibits superspreading and the number of secondary cases is highly overdispersed (k ~ 0.5). 7/n https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2020.25.4.2000058 …Pokaż ten wątek -
That means that many infected cases do not transmit at all, and only a few infected individuals have the potential to initiate a sustained transmission chain. 8/n
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Assuming k = 0.5, we obtain a probability of 58% (for Re = 1.05) and 79% (for Re = 1.1) that the 25 cases will initiate a sustained transmission chain in Switzerland. 9/n
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So that's still relatively high. However, visitors from the UK (and South Africa) must now go into quarantine in Switzerland. This might prevent some of the potential further spread of the new variant. 10/nhttps://www.bag.admin.ch/bag/en/home/krankheiten/ausbrueche-epidemien-pandemien/aktuelle-ausbrueche-epidemien/novel-cov/empfehlungen-fuer-reisende.html …
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Nevertheless, we have to assume that the new variant might start to spread in Switzerland during the coming weeks, particularly because it might have increased transmissibility and therefore a higher Re. End. 11/n
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Isn't Re of the new variant relevant here? Not Re of all the other variants circulating in CH? If (and we don't know for sure) the variant is spreading substantially faster, you'd need to use a higher Re value, right?
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Absolutely, see tweet 11 in this thread. For Re = 1.5 and k = 0.5, we get a probability of ~ 100% that the new variant will start to spread.
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Wouldn't it make more sense to assume Re for new strain is ~70% higher than pop avg since that is reason for concern? Re=~1.75 makes establishment almost certain, no?
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