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C7RKY's profile
John Clarke
John Clarke
John Clarke
@C7RKY

Tweets

John Clarke

@C7RKY

Of course views all mine. All without prejudice. Just a regular chap after all. Oh...and RT's may equally imply ridicule as endorsement.

UK
Joined December 2011

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    1. Ed Yong‏Verified account @edyong209 20 Jan 2016

      No one knows why a French clinical trial went horribly wrong because details of the drug aren't being disclosed http://www.nature.com/news/scientists-in-the-dark-after-french-clinical-trial-proves-fatal-1.19189 …

      3 replies 20 retweets 17 likes
    2. David Colquhoun‏ @david_colquhoun 20 Jan 2016
      Replying to @edyong209

      @edyong209 not that that's an excuse for secrecy, of cousre

      1 reply 0 retweets 0 likes
    3. Adam Jacobs‏ @statsguyuk 20 Jan 2016
      Replying to @david_colquhoun

      @david_colquhoun @edyong209 Also, whoever wrote that Nature article obviously forgot to check Wikipedia http://bit.ly/1nkHiU0 

      1 reply 1 retweet 0 likes
    4. Adam Jacobs‏ @statsguyuk 20 Jan 2016
      Replying to @statsguyuk

      @david_colquhoun @edyong209 The real transparency fail here IMHO is that trial seems not to be registered on ct .gov. No excuse for that.

      2 replies 1 retweet 1 like
    5. John Clarke‏ @C7RKY 20 Jan 2016
      Replying to @statsguyuk

      @statsguyuk @david_colquhoun @edyong209 So even after a fatal incident, it's poss this trial may yet go unregistered/unpublished? Hope not!

      1 reply 0 retweets 0 likes
    6. Adam Jacobs‏ @statsguyuk 20 Jan 2016
      Replying to @C7RKY

      @C7RKY @david_colquhoun @edyong209 Hard to believe it won't be published now, but I'd love to know what happened to registration

      1 reply 1 retweet 0 likes
    7. John Clarke‏ @C7RKY 20 Jan 2016
      Replying to @statsguyuk

      @statsguyuk @david_colquhoun @edyong209 So is this how 50% of studies go 'missing'? What's stopping them 'losing' this one? Just publicity?

      1 reply 0 retweets 0 likes
    8. Adam Jacobs‏ @statsguyuk 20 Jan 2016
      Replying to @C7RKY

      @C7RKY @david_colquhoun @edyong209 It's not true that 50% of trials go missing http://bit.ly/1KkyV4s 

      1 reply 0 retweets 0 likes
    9. John Clarke‏ @C7RKY 20 Jan 2016
      Replying to @statsguyuk

      @statsguyuk @david_colquhoun @edyong209 Whatever the number, we know some trials go missing. Anything but 100% transparency undermines all >

      1 reply 1 retweet 1 like
      John Clarke‏ @C7RKY 20 Jan 2016

      @C7RKY @statsguyuk @david_colquhoun @edyong209 So back to my question - what's stopping them losing this one and adding to the problem?

      9:22 AM - 20 Jan 2016
      • 1 Like
      • Sparkle60
      1 reply 0 retweets 1 like
        1. New conversation
        2. Adam Jacobs‏ @statsguyuk 20 Jan 2016
          Replying to @C7RKY

          @C7RKY @david_colquhoun @edyong209 Ethical requirement to publish. And this: http://bit.ly/1T5giUy 

          1 reply 1 retweet 0 likes
        3. John Clarke‏ @C7RKY 20 Jan 2016
          Replying to @statsguyuk

          @statsguyuk @david_colquhoun @edyong209 Medical ethics no longer offer reassurance for me. And that policy seems to rely on self-reporting?

          1 reply 0 retweets 0 likes
        4. Adam Jacobs‏ @statsguyuk 20 Jan 2016
          Replying to @C7RKY

          @C7RKY Well, the policy relies on the drug being licensed, which I guess isn't going to happen here if the drug was responsible for the harm

          1 reply 1 retweet 0 likes
        5. Adam Jacobs‏ @statsguyuk 20 Jan 2016
          Replying to @statsguyuk

          @C7RKY Though there will be a legal requirement to submit a report to the French authorities in any case.

          1 reply 0 retweets 1 like
        6. Adam Jacobs‏ @statsguyuk 20 Jan 2016
          Replying to @statsguyuk

          @C7RKY I'm afraid I don't know what the French authorities' policy is on public disclosure

          1 reply 0 retweets 0 likes
        7. John Clarke‏ @C7RKY 20 Jan 2016
          Replying to @statsguyuk

          @statsguyuk Appreciated. Does that legal requirement to report stem from harm caused or just because it's a trial? Hardly watertight, is it?

          1 reply 0 retweets 0 likes
        8. Adam Jacobs‏ @statsguyuk 20 Jan 2016
          Replying to @C7RKY

          @C7RKY Because it's a trial of an investigational medicinal product. Harm is not relevant to reporting requirements

          1 reply 1 retweet 1 like
        9. John Clarke‏ @C7RKY 20 Jan 2016
          Replying to @statsguyuk

          @statsguyuk Well that's something. Presume any failure to comply with that requirement wouldn't have been noticed tho, as it's unregistered?

          1 reply 0 retweets 0 likes
        10. 5 more replies

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