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Prikvačeni tweet
Is fruit like eating teaspoons of sugar? Find out the answer...In this short video I cut through the dogma out there & show you exactly what fruit & sugar does to my blood glucose. No bias, let the data do the talking! Please RT https://youtu.be/T9wJQnb_WwI pic.twitter.com/zOcid8uSL8
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Adrian Brown PhD RD proslijedio/la je Tweet
Nice study showing that losing 10% of weight in the first year after T2
#diabetes was associated with 39% T2D remission at 5y. Two imp points: 1. The intervention was NOT low carb; 2. It shows that we need to put WM at the heart of T2D & have multiple approaches to suit pt needshttps://twitter.com/docwas/status/1224068278701654016 …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Final paper is v.elegant study suggesting that intermittent fasting (20hrs water fast every other day for 14days) improved insulin-mediate glucose update independent to wt loss. Appears comprehensive methodology. One point is was done in 2005, not 1985, just for reference. 18/18
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The 2nd paper, I've no idea why you included it, sorry! It's in healthy people & discusses having orange juice in-between meals & it’s affect on energy balance or metabolic risk & nothing to do with meal frequency. This would have been a better paper 17/18https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079942/ …
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Again this is limited to people on metformin, less than 10yrs duration & A1c of 8% or less. Our population was 13yrs duration, HbA1c mean >9% & were all on insulin, so comparison is not possible. 16/18
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The data regarding timing of CHO is actually relevant & I have been following Dr Shukla’s work which is great but it would have been better to link to this study 15/18 https://drc.bmj.com/content/5/1/e000440 … in T2D, BUT
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Main issue with your papers are none are in our pt population. Your paper 1=prediabetes 2=healthy subjects 3=healthy men - so are you saying from the data you presented is that in 'people who don’t have T2D that food order and timing is important?' 14/18https://twitter.com/raphaels7/status/1223326908739391488?s=20 …
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Also you mention adherence as an issue but identical drop out with or without a ketogenic diet, strange! Also see this data comparing LED with controls in systematic review & no difference. 13/18 https://onlinelibrary.wiley.com/doi/full/10.1111/obr.12366 …pic.twitter.com/Rr01Bk4YEg
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Adherence on the diets showed 12 VLCK and 14 LC dropout so data was not powered to meet the primary outcome using only completer. Although they did use ITT which would be more relevant when interpreting data. 12/18
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Couple of issues in comparing our data is that they excluded insulin therapy & only focussed on people with obesity. In addition with from their statistics section needed at least 30 each arm to detect different in weight loss HOWEVER 11/18
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This ketogenic diet however is similar to our intervention in that the very low calorie-ketogenic diet was actually PronoKal https://www.pronokalgroup.com/en/ukn/methods-and-programmes/pnk/products/ … It's a formula type programme, using shakes, bars, soup to enable energy restriction then involved food reintroduction 10/18pic.twitter.com/QGM61vrfMh
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This is a nice study. https://www.ncbi.nlm.nih.gov/pubmed/24584583 BUT: The low calorie diet here is comparable to our control group using calorie ranged from 1400 to 1800kcal, so it not low calorie rather energy restrictive diet, for reference low energy diet defined as 800-1200kcal/day. 9/18
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You're focusing on wrong number, this is designed to be energy restrictive, total CHO is <130g so by definition
#lowcarb but is not a#lowCHO product as main mechanism is energy restriction. Please look at fasting BG, for impact of#LED on glucose 8/18https://twitter.com/raphaels7/status/1223328942406479874?s=20 …
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Keys starvation studies was not using formula
#LED products, all wt loss no matter what method you lose FFM, data from LED is 14% & 23.4% FFM loss see my review https://onlinelibrary.wiley.com/doi/full/10.1111/nbu.12372 …@virtahealth data=14% FFM losses in lower extremities, so no diff. 7/18https://twitter.com/raphaels7/status/1223328942406479874?s=20 …
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Please see long-term data is using LED in OA patients - 4yrs using continued formula products to enable energy restriction to be continued. 6/18https://academic.oup.com/ajcn/article/106/3/755/4822390 …
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Next up. There is no direct study comparing the two modalities your making assumptions here & where is your data for long-term adherence to ketogenic diets? As all the data I’ve seen is that overtime adherence reduces, even in studies measuring BHB. 5/18https://twitter.com/raphaels7/status/1223900750717296640?s=20 …
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Finally, used repeated T-test without reported corrections, so may have had Type 1 error. And as completer only this may have biased the results. But it did show that LCKD was beneficial in comparison to traditional energy restrictive diet in people with and without
#T2D. 4/18Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
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Unclear this paper demonstrates your point. Firstly, title is misleading as more people were without T2D than with it (72% without, 28% with T2D). LCD was not well described but was an energy restrictive diet so similar to our control group & was not a formula
#LED 2/18Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Firstly thanks
@raphaels7 for sending response. Now reviewed papers you sent to try & make your points & have a few issues with design, relevance & comparability with our paper published this wk in pts with T2D & treated with insulin https://drc.bmj.com/content/8/1/e001012 … . See thread 1/18https://twitter.com/raphaels7/status/1223900135677222912 …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Adrian Brown PhD RD proslijedio/la je Tweet
Who wants a year-long fellowship that’s 70% quality improvement projects & 30% leadership training (that’s training just for yourself)? Winners, that’s who.
@uclh Transforming End of Life Care Leadership Fellow applications are almost here. DM for details, advert coming soonHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi
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significant in subjects who were on the LCKD as compared with those on the LCD