Adrian Brown PhD RD

@BrownAdey

Specialist Dietitian & Researcher Views are my own Retweet is not endorsement

Vrijeme pridruživanja: lipanj 2013.

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  1. Prikvačeni tweet
    27. stu 2018.

    Is fruit like eating teaspoons of sugar? Find out the answer...In this short video I cut through the dogma out there & show you exactly what fruit & sugar does to my blood glucose. No bias, let the data do the talking! Please RT

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  2. proslijedio/la je Tweet
    prije 22 sata

    Nice study showing that losing 10% of weight in the first year after T2 was associated with 39% T2D remission at 5y. Two imp points: 1. The intervention was NOT low carb; 2. It shows that we need to put WM at the heart of T2D & have multiple approaches to suit pt needs

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  3. 2. velj

    Final paper is v.elegant study suggesting that intermittent fasting (20hrs water fast every other day for 14days) improved insulin-mediate glucose update independent to wt loss. Appears comprehensive methodology. One point is was done in 2005, not 1985, just for reference. 18/18

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  4. 2. velj

    The 2nd paper, I've no idea why you included it, sorry! It's in healthy people & discusses having orange juice in-between meals & it’s affect on energy balance or metabolic risk & nothing to do with meal frequency. This would have been a better paper 17/18

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  5. 2. velj

    Again this is limited to people on metformin, less than 10yrs duration & A1c of 8% or less. Our population was 13yrs duration, HbA1c mean >9% & were all on insulin, so comparison is not possible. 16/18

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  6. 2. velj

    The data regarding timing of CHO is actually relevant & I have been following Dr Shukla’s work which is great but it would have been better to link to this study 15/18 in T2D, BUT

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  7. 2. velj

    Main issue with your papers are none are in our pt population. Your paper 1=prediabetes 2=healthy subjects 3=healthy men - so are you saying from the data you presented is that in 'people who don’t have T2D that food order and timing is important?' 14/18

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  8. 2. velj

    Also you mention adherence as an issue but identical drop out with or without a ketogenic diet, strange! Also see this data comparing LED with controls in systematic review & no difference. 13/18

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  9. 2. velj

    Adherence on the diets showed 12 VLCK and 14 LC dropout so data was not powered to meet the primary outcome using only completer. Although they did use ITT which would be more relevant when interpreting data. 12/18

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  10. 2. velj

    Couple of issues in comparing our data is that they excluded insulin therapy & only focussed on people with obesity. In addition with from their statistics section needed at least 30 each arm to detect different in weight loss HOWEVER 11/18

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  11. 2. velj

    This ketogenic diet however is similar to our intervention in that the very low calorie-ketogenic diet was actually PronoKal It's a formula type programme, using shakes, bars, soup to enable energy restriction then involved food reintroduction 10/18

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  12. 2. velj

    This is a nice study. BUT: The low calorie diet here is comparable to our control group using calorie ranged from 1400 to 1800kcal, so it not low calorie rather energy restrictive diet, for reference low energy diet defined as 800-1200kcal/day. 9/18

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  13. 2. velj

    You're focusing on wrong number, this is designed to be energy restrictive, total CHO is <130g so by definition but is not a product as main mechanism is energy restriction. Please look at fasting BG, for impact of on glucose 8/18

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  14. 2. velj

    Keys starvation studies was not using formula products, all wt loss no matter what method you lose FFM, data from LED is 14% & 23.4% FFM loss see my review data=14% FFM losses in lower extremities, so no diff. 7/18

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  15. 2. velj

    Please see long-term data is using LED in OA patients - 4yrs using continued formula products to enable energy restriction to be continued. 6/18

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  16. 2. velj

    Next up. There is no direct study comparing the two modalities your making assumptions here & where is your data for long-term adherence to ketogenic diets? As all the data I’ve seen is that overtime adherence reduces, even in studies measuring BHB. 5/18

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  17. 2. velj

    Finally, used repeated T-test without reported corrections, so may have had Type 1 error. And as completer only this may have biased the results. But it did show that LCKD was beneficial in comparison to traditional energy restrictive diet in people with and without . 4/18

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  18. 2. velj

    So not comparable to our outcomes. Only 24 weeks data. No. of was not matched between groups & LCKD diet were heavier & had better diabetes control at baseline & not corrected for. They also only used completer data not ITT, but no data available on adherence. 3/18

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  19. 2. velj

    Unclear this paper demonstrates your point. Firstly, title is misleading as more people were without T2D than with it (72% without, 28% with T2D). LCD was not well described but was an energy restrictive diet so similar to our control group & was not a formula 2/18

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  20. 2. velj

    Firstly thanks for sending response. Now reviewed papers you sent to try & make your points & have a few issues with design, relevance & comparability with our paper published this wk in pts with T2D & treated with insulin . See thread 1/18

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  21. proslijedio/la je Tweet
    1. velj

    Who wants a year-long fellowship that’s 70% quality improvement projects & 30% leadership training (that’s training just for yourself)? Winners, that’s who. Transforming End of Life Care Leadership Fellow applications are almost here. DM for details, advert coming soon

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