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BretWeinstein's profile
Bret Weinstein
Bret Weinstein
Bret Weinstein
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@BretWeinstein

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Bret WeinsteinVerified account

@BretWeinstein

DarkHorse Podcast. Professor in Exile. Evolutionary Trade-Offs. Telomeres. Emoticons imply irony. Reluctant Radical. Game~B/Fourth Frontier—Hard To Silence

Oregon, USA
youtube.com/BretWeinsteinD…
Joined September 2009

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    Bret Weinstein‏Verified account @BretWeinstein Jul 15

    Those who argue that large scale randomized controlled trials are the only reliable evidence in evidence based medicine have misled you. Now you can see why—large RCTs amplify systematic error in addition to signal, whereas meta-analysis amplifies signal, and corrects for error.

    5:47 PM - 15 Jul 2021
    • 607 Retweets
    • 3,643 Likes
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    300 replies 607 retweets 3,643 likes
      1. Bret Weinstein‏Verified account @BretWeinstein Jul 15

        I don’t know if the study in question is fatally flawed, or worse. But nothing rests on it. The remaining evidence points in the same direction. Can the public track the evidentiary signal through the noise of a fraud allegation? Time will tell.https://grftr.news/why-was-a-major-study-on-ivermectin-for-covid-19-just-retracted/ …

        199 replies 325 retweets 1,835 likes
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      2. PB Firearms‏ @FirearmsPB Jul 15
        Replying to @BretWeinstein

        Have FOIA'd whether you are one of Psaki's 12 disciples she is trying to silence?

        2 replies 0 retweets 8 likes
      3. PB Firearms‏ @FirearmsPB Jul 15
        Replying to @FirearmsPB @BretWeinstein

        *you

        2 replies 0 retweets 1 like
      4. End of conversation
      1. Neil Griseto‏ @Dr__G Jul 15
        Replying to @BretWeinstein

        Meta-analysis is highly susceptible to garbage in, garbage out. There is a heirarchy of evidence, the reason being to try to counter bias which is one error humans are very incapable of controlling. Evidence based medicine is not top trumps.

        0 replies 0 retweets 22 likes
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      2. Patrick M Looser MD‏ @PLooserMD Jul 15
        Replying to @BretWeinstein

        Unless the studies included in the meta analysis are flawed. In which case they amplify error. Which is what happened with ivermectin.

        14 replies 3 retweets 219 likes
      3. Show replies
      1. Adam V Steele‏ @adamvsteele Jul 15
        Replying to @BretWeinstein

        I disagree Brett. Meta analysis are highly malleable. IOW, the researchers have too many degrees of freedom when interpreting the data. You can readily have two groups with the same studies coming to different conclusions. Recommend:https://www.amazon.com/Medical-Nihilism-Jacob-Stegenga/dp/0198747209 …

        0 replies 2 retweets 55 likes
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      1. The Policy Lass‏ @thepolicylass Jul 15
        Replying to @BretWeinstein

        With meta-analysis, it's GIGO. Garbage in, garbage out. RCTs still the best.https://www.nejm.org/doi/full/10.1056/NEJM199708213370806 …

        0 replies 0 retweets 35 likes
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      2. Carlos R. Escalante‏ @crescalantelab Jul 15
        Replying to @BretWeinstein

        This is true only when the RCTs are poorly designed, executed and analyzed. That was the whole point of many scientists pointing to the poor quality in many of those studies used in the meta-analysis. Garbage in, garbage out.

        1 reply 2 retweets 98 likes
      3. Strxwmxn  🌵‏ @strxwmxn Jul 15
        Replying to @crescalantelab @BretWeinstein

        Exactly. Meta-analysis trades some biases with RCT for biases of its own: publication bias, sample bias, search bias.

        1 reply 0 retweets 27 likes
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