2. We think about the clinical spectrum of illness in many ways, including: asymptomatic <-> subclinical<-> clinical Within "clinical" there can be a wide range of symptoms, from mild to severe.
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3. "subclinical" is interesting because it means people may have symptoms of varying degrees, but have not sought medical care. This is influenced by many factors (e.g. culture, personal, health resources available, geography, etc).
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4. in the
@NEJM study they report: "it is notable that the infection appears to have been transmitted during the incubation period of the index patient, in whom the illness was brief and nonspecific." ....Prikaži ovu nit -
5. There are other discussions about asymptomatic transmission. This is interesting, and sounds like it is certainly contributing to some people getting infected. But which type of infected person would be more likely to spread infection to a greater number of people?...
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6. Usually it is symptomatic people - these people are infected and transmitting virus to others and the environment, facilitated by coughing. Still, it appears asymptomatic people can transmit. But in general, when it comes to resp infections, those with symptoms transmit more
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7. If symptomatic people are quickly identified and given the opportunity to prevent transmission to others (e.g. given a mask; limit contact with others), this can significantly reduce transmission. This requires public education, public health, and healthcare capacity.
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8. And of course we all have to be humble and open minded here. We do not have all the answers. We are learning more about the biology of this virus, its transmission dynamics, and clinical spectrum every day. Let's manage by fact.
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