Jark Boettcher

@BoettcherJark

Protein crystallographer, FBS and SBDD enthusiast

Vrijeme pridruživanja: srpanj 2019.

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  1. 17. pro 2019.

    Fascinating story and a well-characterized chemical probe!

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  2. 21. stu 2019.
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    and colleagues go after tough cancer metabolism target PHGDH with and to generate inhibitor BI-4924 and its ester prodrug BI-4916 that can disrupt serine biosynthesis  

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  4. 30. ruj 2019.

    Happy to share that the chemical probe BI-9321 and the related negative control BI-9466 described in Nature Chemical Biology () are now available via opnMe ().

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  5. 23. ruj 2019.

    Great visualisation and in spite of significant progress still some work ahead.

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    Haresh Ajani assesses a virtual screening method customized for . notebook: Blog:

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    See news article today on . Imagine the discoveries that could be made for health and medicine if we had a pharmacological modulator for every protein. Join us in the effort

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    15. kol 2019.

    Knowledge on purifying larger protein complexes and on looking at them on an atomar level with X-ray crystallography or EM would complete the profile.

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  9. 13. kol 2019.

    Congrats to the team of and for the discovery and characterization of a chemical probe for NSD2-PWWP1

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  10. 23. srp 2019.

    Grear summary of the FBS approaches performed to obtain the chemical probe BI-9321 by Dan Erlanson

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  11. 11. srp 2019.

    The chemical probe for the PWWP1 domain of NSD3 (BI-9321) is available via the SGC homepage (). The joint publication of scientist from , ,, and describing the discovery and characterization is now online.

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