Mikhail V Blagosklonny, MD, PhD

@Blagosklonny

Professor of Oncology In search of Immortality. Cutting-edge Anti-aging information. Prolific author . Editor: Oncotarget, Aging

USA
Vrijeme pridruživanja: siječanj 2017.

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  1. Prikvačeni tweet

    Revolutionary study. Resistance causes rapid clearance of cells in human skeletal muscle. Resistance exercise is an ideal

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  3. A company selling young plasma is running again because demand is still high despite FDA's buyer beware letter

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  5. Two classes of potential anti-aging drugs - senolytics (kill cells) and gero-suppressants (target growth/ signaling pathways such as mTOR, AMPK, insulin, MEK) overlap

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    2. velj

    pandemic has now officially exceeded SARS in cumulative cases in just two weeks.

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  7. Millions of humans experimented with various diets, including those that we are practicing but no one has achieved exceptional longevity. In addition to diets that improve health, we need drugs that slow or reprogram course of aging. Synergy with diets

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  8. Luteolin suppresses bladder cancer by inhibiting the target of rapamycin. Why then not to use rapamycin instead? Rapamycin is also a natural product but much more effective and selective. Any explanations?

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  9. Good video (in mice). And rapamycin is already in use for prevention of Alzheimer’s in humans

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  10. Nice journal club. To better understand rapamycin as a skin cosmetic you may read a very short editorial first

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  11. Just to add that insulin by itself increase insulin resistance, and this in turn increases insulin levels, potentially leading to exhaustion

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  12. Yes, insulin. activates mTOR and can accelerate diabetic complications such as . Yet, it is also tip of the iceberg

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  13. A new study , which blocks digestion of carbohydrates, prolongs life in cancer-prone mice. This drug is just an imperfect substitute for Very Low Carb Diet. In humans such healthy diet is mostly used as diets

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  14. (Note: Children especially like sweets that activate mTOR). Later in life mTOR drives aging and diseases but evolution does not care. Thus mTOR driven growth, becomes a quasi-program of aging

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  15. Although ketosis may delay age-related diseases, Evolution does not care about longevity benefits later in life, only about developmental growth. This growth is driven by mTOR in part, so evolution selects for robust mTOR. And ketones inhibit mTOR, whereas mTOR inhibits ketones

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  16. Its known since 1928 that Inuit people, Escimos, are not in ketosis on their diet. Evolution selected for mutation that prevents on such a diet. The question is why?

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  17. Just to clarify my previous point. No need to avoid fruits because of anti-oxidants, but also no need to eat fruits because (!) of anti-oxidants. Someone who wants diet, can avoid fruits, without regretting (worrying) that they do not get "enough"

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  18. Ironically, this is additional reason to avoid carbs. Not only may not be needed, they may increase risk of , as found in randomized clinical trials terminated earlier for that reason (see example)

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  20. Intriguingly, disulfiram, used to treat alcohol dependence, selectively kills cancer cells with 16q chromosome deletion, which is often seen in breast and ovarian cancers See original article

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    29. sij

    The negativity effect = our tendency to respond more strongly to negative events than positive ones. When we hear compliments and criticism, we obsess over the criticism instead of enjoying the praise.

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