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BillHanage's profile
Bill Hanage
Bill Hanage
Bill Hanage
Verified account
@BillHanage

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Bill HanageVerified account

@BillHanage

Assoc Prof at Harvard T. H. Chan School of Public Health and Gooner. Currently cosplaying Dr Rieux in some weird re-enactment of La Peste. Tweets are personal

iPhone: 51.510544,-0.133636
ccdd.hsph.harvard.edu/about/Faculty/…
Joined February 2009

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    1. Bill Hanage‏Verified account @BillHanage 26 Apr 2021

      I am seeing a lot of anxiety around partial immunity through vaccination producing selection for escape variants. Here @colinrussell and I explain why we *don't* think that's likely 1/n https://science.sciencemag.org/content/372/6540/354.1 …

      15 replies 182 retweets 474 likes
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    2. Bill Hanage‏Verified account @BillHanage 26 Apr 2021

      It depends on the supply of the mutations that enable immune evasion. If we assume this happens during breakthrough cases in vaccinated people, there's not much time for it to make a difference, because transmission tends to happen early on in infection 2/n

      1 reply 5 retweets 41 likes
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    3. Bill Hanage‏Verified account @BillHanage 26 Apr 2021

      And if breakthrough cases are less likely to transmit in general (as seems so in at least some cases) that makes it even more difficult 3/n https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3815668 …

      2 replies 4 retweets 36 likes
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    4. Bill Hanage‏Verified account @BillHanage 26 Apr 2021

      Selection is certainly a really powerful force, but it gets a helping hand from 'standing variation' meaning diversity in the population in vulnerability to the selective pressure before it is introduced - in its absence, they don't get selected. But that can change 4/n

      1 reply 6 retweets 37 likes
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      Bill Hanage‏Verified account @BillHanage 26 Apr 2021

      What leads to a lot of diversity in the viral population? A lot of infections! And what is the best way to reduce infections? Vaccination! (aided and abetted by non-pharmaceutical interventions natch) 5/n

      2:20 PM - 26 Apr 2021
      • 28 Retweets
      • 105 Likes
      • Proud European from Austria🇪🇺🇦🇹 🌏 _ michael Chris Boles ewet Nídia Trovão Kasper Planeta Kepp mysocalledlife Samantha Chalmers Massimo S
      4 replies 28 retweets 105 likes
        1. New conversation
        2. Bill Hanage‏Verified account @BillHanage 26 Apr 2021

          For more thorough explanation going deeper into this and considering other angles, read this from @sarahcobey @mlipsitch @DanLarremore https://nature.com/articles/s41577-021-00544-9 … 6/n

          2 replies 9 retweets 45 likes
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        3. Bill Hanage‏Verified account @BillHanage 26 Apr 2021

          I can see some questions about infections in immunocompromised individuals. I think we need to watch these extremely carefully. Not clear to me that less immunity will provide more selection, but our experience so far should lead to vigilance 7/n

          2 replies 3 retweets 40 likes
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        4. Bill Hanage‏Verified account @BillHanage 26 Apr 2021

          And of course the best way to stop infections in the immunocompromised is to stop the virus before it can get to them! And vaccination will help with that too 8/n

          1 reply 4 retweets 54 likes
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        5. Bill Hanage‏Verified account @BillHanage 26 Apr 2021

          Now there is still a lot of infection, but there are a lot of vaccines too (and vaccinated people). We are continuing to learn more about them including how they work against variants. That will be something to watch closely in the coming months 9/n

          1 reply 5 retweets 33 likes
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        6. Bill Hanage‏Verified account @BillHanage 26 Apr 2021

          But for now we should remember we are in a MUCH better place than we were, that every day brings us closer to the end, and that our attention should turn to those parts of the world still struggling to get people vaccinated 10/end

          9 replies 9 retweets 90 likes
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        7. End of conversation
        1. GigaGerard‏ @GigaGerard 26 Apr 2021
          Replying to @BillHanage

          Researchers on the British variant wrote that treating patients with antivirals like Remdesivir may have caused its many new mutations. Does it worry you that in India favipiravir is cheaply produced and I assume prescribed for Covid?https://www.reuters.com/world/china/covid-19-infections-surge-nepal-fueled-by-mutant-strains-india-2021-04-26/ …

          0 replies 2 retweets 2 likes
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        1. SilviaB‏ @parloamestessa 26 Apr 2021
          Replying to @BillHanage

          The best way to reduce infections is by severe lockdowns. It should be recommended to reduce drastically virus circulation before mass vaccination, to prevent new "vaccine resistant" vocs... in Italy we are doing the opposite, alas

          0 replies 0 retweets 2 likes
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        1. Ketan Kurtadikar‏ @KurtadikarKetan 27 Apr 2021
          Replying to @BillHanage

          @macroliter

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