I am seeing a lot of anxiety around partial immunity through vaccination producing selection for escape variants. Here @colinrussell and I explain why we *don't* think that's likely 1/n https://science.sciencemag.org/content/372/6540/354.1 …
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For more thorough explanation going deeper into this and considering other angles, read this from
@sarahcobey@mlipsitch@DanLarremore https://nature.com/articles/s41577-021-00544-9 … 6/nShow this thread -
I can see some questions about infections in immunocompromised individuals. I think we need to watch these extremely carefully. Not clear to me that less immunity will provide more selection, but our experience so far should lead to vigilance 7/n
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And of course the best way to stop infections in the immunocompromised is to stop the virus before it can get to them! And vaccination will help with that too 8/n
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Now there is still a lot of infection, but there are a lot of vaccines too (and vaccinated people). We are continuing to learn more about them including how they work against variants. That will be something to watch closely in the coming months 9/n
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But for now we should remember we are in a MUCH better place than we were, that every day brings us closer to the end, and that our attention should turn to those parts of the world still struggling to get people vaccinated 10/end
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End of conversation
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Researchers on the British variant wrote that treating patients with antivirals like Remdesivir may have caused its many new mutations. Does it worry you that in India favipiravir is cheaply produced and I assume prescribed for Covid?https://www.reuters.com/world/china/covid-19-infections-surge-nepal-fueled-by-mutant-strains-india-2021-04-26/ …
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The best way to reduce infections is by severe lockdowns. It should be recommended to reduce drastically virus circulation before mass vaccination, to prevent new "vaccine resistant" vocs... in Italy we are doing the opposite, alas
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